Early germline sequestration in a basidiomycete fungus

• 成果类型: Article
• 署名作者: Thoren, Markus Hiltunen; Olsson, Boel; Vonk, Peter Jan; Siljestam, Mattias; Reimegard, Johan; Ryberg, Martin; Johannesson, Hanna
• 署名单位: Stockholm University; Royal Swedish Academy of Sciences; Uppsala University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11739
• DOI: 10.1126/science.adu8580
• 发表日期: 2025-08-14
• 页码: 720-723
• 关键词: mutation-rates; life-span; cell; mechanisms; EVOLUTION; format; genome

摘要

In sexual organisms, inheritance of new mutations is highly dependent on the timing of germline definition. Here, we used the fairy ring-forming fungus Marasmius oreades to challenge the general assumption of a late germline separation in the Fungi. We collected mushrooms from different parts of rings over a 7-year period and identified new mutations in different tissues by whole-genome sequencing. We found evidence that fertile and sterile tissues had accumulated different mutations, suggesting that the germ line, destined for spore production, is already defined in the mycelium in this species. Moreover, the germ line carried fewer mutations than sterile tissues, indicating a lower mutation rate. Our findings suggest that early germline sequestration is more widespread than previously considered across multicellular life.