1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

• 成果类型: Article
• 署名作者: Crawford, Jacob E.; Balcazar, Dario; Redmond, Seth; Rose, Noah H.; Youd, Henry A.; Lucas, Eric R.; Ali, Rusdiyah Sudirman Made; Alnazawi, Ashwaq; Badolo, Athanase; Chen, Chun-Hong; Cosme, Luciano V.; Henke, Jennifer A.; Hung, Kim Y.; Kluh, Susanne; Liu, Wei-Liang; Maringer, Kevin; Martins, Ademir; Micieli, Maria Victoria; Pless, Evlyn; Sombie, Aboubacar; Surendran, Sinnathamby N.; Wahid, Isra; Armbruster, Peter A.; Weetman, David; McBride, Carolyn S.; Gloria-Soria, Andrea; Powell, Jeffrey R.; White, Bradley J.
• 署名单位: Yale University; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of La Plata; Connecticut Agricultural Experiment Station; Yale University; Princeton University; Princeton University; University of Liverpool; Liverpool School of Tropical Medicine; National Research & Innovation Agency of Indonesia (BRIN); Jazan University; Universite Joseph Ki-Zerbo; National Health Research Institutes - Taiwan; University of California System; University of California Riverside; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Pirbright Institute; Fundacao Oswaldo Cruz; University Jaffna; Georgetown University; Alphabet Inc.; Google Incorporated; University of California System; University of California San Diego
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13547
• DOI: 10.1126/science.ads3732
• 发表日期: 2025-09-18
• 关键词: mosquito preference; diptera-culicidae; population; EVOLUTION; FRAMEWORK; BEHAVIOR; association; washington; DISCOVERY; vectors

摘要

The emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies Ae. aegypti aegypti (Aaa) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that Aaa movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.