Adaptations to water stress and pastoralism in the Turkana of northwest Kenya

• 成果类型: Article
• 署名作者: Lea, A. J.; Caldas, I. V.; Garske, K. M.; Gerlinger, E. R.; Arroyo, J. P.; Echwa, J.; Gurven, M.; Handley, C.; Kahumbu, J. C.; Kamau, J.; Kinyua, P.; Lotukoi, F.; Lopurudoi, A.; Lowasa, S.; Njeru, S. N.; Mallarino, R.; Martins, D. J.; Messer, P. W.; Miano, C.; Muhoya, B.; Peng, J.; Phung, T.; Rabinowitz, J. D.; Roichman, A.; Siford, R.; Stone, A. C.; Oill, A. M. Taravella; Mathew, S.; Wilson, M. A.; Ayroles, J. F.
• 署名单位: Vanderbilt University; Cornell University; Princeton University; Princeton University; Vanderbilt University; University of California System; University of California Santa Barbara; Arizona State University; Arizona State University-Tempe; University of Nairobi; Kenya Medical Research Institute; Princeton University; State University of New York (SUNY) System; Stony Brook University; Princeton University; Ludwig Institute for Cancer Research; Princeton University; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of California System; University of California Berkeley
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12766
• DOI: 10.1126/science.adv2467
• 发表日期: 2025-09-18
• 页码: 1246-1251
• 关键词: renal ischemia/reperfusion injury; stanniocalcin-1 gene; lactase persistence; positive selection; r package; alignment; AFRICA; association; expression; genomes

摘要

The Turkana pastoralists of Kenya inhabit arid, water-limited environments and rely largely on livestock for subsistence. Working with Turkana communities, we sequenced 367 whole genomes and identified eight regions with evidence for recent positive selection. One of these regions includes a putative regulatory element for STC1-a kidney-expressed gene involved in metabolism and the response to dehydration. We show that STC1 is induced by antidiuretic hormone in human cells, is associated with urea levels in the Turkana themselves, and is under strong and recent selection in this population as well as a second East African population, the Daasanach. This work highlights how integrating anthropological and genomic approaches can lead to a new understanding of human physiology with biomedical relevance.