Ancient Plasmodium genomes shed light on the history of human malaria

• 成果类型: Article
• 署名作者: Michel, Megan; Skourtanioti, Eirini; Pierini, Federica; Guevara, Evelyn K.; Moetsch, Angela; Kocher, Arthur; Barquera, Rodrigo; Bianco, Raffaela A.; Carlhoff, Selina; Coppola Bove, Lorenza; Freilich, Suzanne; Giffin, Karen; Hermes, Taylor; Hiss, Alina; Knolle, Florian; Nelson, Elizabeth A.; Neumann, Gunnar U.; Papac, Luka; Penske, Sandra; Rohrlach, Adam B.; Salem, Nada; Semerau, Lena; Villalba-Mouco, Vanessa; Abadie, Isabelle; Aldenderfer, Mark; Beckett, Jessica F.; Brown, Matthew; Campus, Franco G. R.; Chenghwa, Tsang; Cruz Berrocal, Maria; Damasek, Ladislav; Carlson, Kellie Sara Duffett; Durand, Raphael; Ernee, Michal; Fantaneanu, Cristinel; Frenzel, Hannah; Garcia Atienzar, Gabriel; Guillen, Sonia; Hsieh, Ellen; Karwowski, Maciej; Kelvin, David; Kelvin, Nikki; Khokhlov, Alexander; Kinaston, Rebecca L.; Korolev, Arkadii; Krettek, Kim-Louise; Kuessner, Mario; Lai, Luca; Look, Cory; Majander, Kerttu; Mandl, Kirsten; Mazzarello, Vittorio; McCormick, Michael; de Miguel Ibanez, Patxuka; Murphy, Reg; Nemeth, Rita E.; Nordqvist, Kerkko; Novotny, Friederike; Obenaus, Martin; Olmo-Enciso, Lauro; Onkamo, Paivi; Orschiedt, Joerg; Patrushev, Valerii; Peltola, Sanni; Romero, Alejandro; Rubino, Salvatore; Sajantila, Antti; Salazar-Garcia, Domingo C.; Serrano, Elena; Shaydullaev, Shapulat; Sias, Emanuela; Slaus, Mario; Stanco, Ladislav; Swanston, Treena; Teschler-Nicola, Maria; Valentin, Frederique; Van de Vijver, Katrien; Varney, Tamara L.; Vigil-Escalera Guirado, Alfonso; Waters, Christopher K.; Weiss-Krejci, Estella; Winter, Eduard; Lamnidis, Thiseas C.; Pruefer, Kay; Naegele, Kathrin; Spyrou, Maria; Schiffels, Stephan; Stockhammer, Philipp W.; Haak, Wolfgang; Posth, Cosimo; Warinner, Christina; Bos, Kirsten I.; Herbig, Alexander; Krause, Johannes
• 署名单位: Max Planck Society; Harvard University; University of Helsinki; Max Planck Society; University of Granada; University of Vienna; University of Basel; University of Arkansas System; University of Arkansas Fayetteville; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Adelaide; University of Adelaide; University of Zaragoza; Universite de Caen Normandie; University of California System; University of California Merced; State University of New York (SUNY) System; Farmingdale State College; University of Sassari; National Tsing Hua University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencias del Patrimonio (INCIPIT); Charles University Prague; University of Vienna; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bordeaux; Czech Academy of Sciences; Institute of Archaeology of the Czech Academy of Sciences - Prague; Leipzig University; Universitat d'Alacant; University of Vienna; Dalhousie University; Samara State University of Social Sciences & Education; Griffith University; Eberhard Karls University of Tubingen; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); University of North Carolina; University of North Carolina Charlotte; University of Basel; University of Sassari; Harvard University; University of Nebraska System; University of Nebraska Lincoln; University of Helsinki; Universidad de Alcala; University of Turku; Free University of Berlin; Mari State University; University of Helsinki; Universitat d'Alacant; University of Valencia; University of Cape Town; Universidad de Cantabria; Termez State Pedagogical Institute; Croatian Academy of Sciences & Arts; MacEwan University; Centre National de la Recherche Scientifique (CNRS); Royal Belgian Institute of Natural Sciences; KU Leuven; Lakehead University; Universidad Carlos III de Madrid; Austrian Academy of Sciences; Ruprecht Karls University Heidelberg; University of Vienna; Eberhard Karls University of Tubingen; University of Munich; Harvard University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-6950
• DOI: 10.1038/s41586-024-07546-2
• 发表日期: 2024-07-04
• 页码: 125-+
• 关键词: falciparum malaria; genetic diversity; vivax malaria; dna; sequence; evolutionary; FRAMEWORK; emergence; Europe; cave

摘要

Malaria-causing protozoa of the genus Plasmodium have exerted one of the strongest selective pressures on the human genome, and resistance alleles provide biomolecular footprints that outline the historical reach of these species(1). Nevertheless, debate persists over when and how malaria parasites emerged as human pathogens and spread around the globe(1,2). To address these questions, we generated high-coverage ancient mitochondrial and nuclear genome-wide data from P. falciparum, P. vivax and P. malariae from 16 countries spanning around 5,500 years of human history. We identified P. vivax and P. falciparum across geographically disparate regions of Eurasia from as early as the fourth and first millennia BCE, respectively; for P. vivax, this evidence pre-dates textual references by several millennia(3). Genomic analysis supports distinct disease histories for P. falciparum and P. vivax in the Americas: similarities between now-eliminated European and peri-contact South American strains indicate that European colonizers were the source of American P. vivax, whereas the trans-Atlantic slave trade probably introduced P. falciparum into the Americas. Our data underscore the role of cross-cultural contacts in the dissemination of malaria, laying the biomolecular foundation for future palaeo-epidemiological research into the impact of Plasmodium parasites on human history. Finally, our unexpected discovery of P. falciparum in the high-altitude Himalayas provides a rare case study in which individual mobility can be inferred from infection status, adding to our knowledge of cross-cultural connectivity in the region nearly three millennia ago.