How to design a protein that can be switched on and off

• 成果类型: Editorial Material
• 署名作者: Wand, A. Joshua
• 署名单位: Texas A&M University System; Texas A&M University College Station
• 刊物名称: Nature
• ISSN/ISSBN: 0028-4136
• DOI: 10.1038/d41586-024-02242-7
• 发表日期: 2024-08-14
• 页码: 741-742
• 关键词: 3-dimensional fourier synthesis

摘要

Proteins have been designed that assemble in different ways depending on whether an 'effector' molecule is present - a demonstration of allostery, the phenomenon that enables switch-like control of protein functions in nature. Designer proteins that exhibit the phenomenon of allostery.