Harnessing landrace diversity empowers wheat breeding

• 成果类型: Article
• 署名作者: Cheng, Shifeng; Feng, Cong; Wingen, Luzie U.; Cheng, Hong; Riche, Andrew B.; Jiang, Mei; Leverington-Waite, Michelle; Huang, Zejian; Collier, Sarah; Orford, Simon; Wang, Xiaoming; Awal, Rajani; Barker, Gary; O'Hara, Tom; Lister, Clare; Siluveru, Ajay; Quiroz-Chavez, Jesus; Ramirez-Gonzalez, Ricardo H.; Bryant, Ruth; Berry, Simon; Bansal, Urmil; Bariana, Harbans S.; Bennett, Malcolm J.; Bicego, Breno; Bilham, Lorelei; Brown, James K. M.; Burridge, Amanda; Burt, Chris; Buurman, Milika; Castle, March; Chartrain, Laetitia; Chen, Baizhi; Denbel, Worku; Elkot, Ahmed F.; Fenwick, Paul; Feuerhelm, David; Foulkes, John; Gaju, Oorbessy; Gauley, Adam; Gaurav, Kumar; Hafeez, Amber N.; Han, Ruirui; Horler, Richard; Hou, Junliang; Iqbal, Muhammad S.; Kerton, Matthew; Kondic-Spica, Ankica; Kowalski, Ania; Lage, Jacob; Li, Xiaolong; Liu, Hongbing; Liu, Shiyan; Lovegrove, Alison; Ma, Lingling; Mumford, Cathy; Parmar, Saroj; Philp, Charlie; Playford, Darryl; Przewieslik-Allen, Alexandra M.; Sarfraz, Zareen; Schafer, David; Shewry, Peter R.; Shi, Yan; Slafer, Gustavo A.; Song, Baoxing; Song, Bo; Steele, David; Steuernagel, Burkhard; Tailby, Phillip; Tyrrell, Simon; Waheed, Abdul; Wamalwa, Mercy N.; Wang, Xingwei; Wei, Yanping; Winfield, Mark; Wu, Shishi; Wu, Yubing; Wulff, Brande B. H.; Xian, Wenfei; Xu, Yawen; Xu, Yunfeng; Yuan, Quan; Zhang, Xin; Edwards, Keith J.; Dixon, Laura; Nicholson, Paul; Chayut, Noam; Hawkesford, Malcolm J.; Uauy, Cristobal; Sanders, Dale; Huang, Sanwen; Griffiths, Simon
• 署名单位: Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Guangdong Laboratory for Lingnan Modern Agriculture; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Rothamsted Research; Northwest A&F University - China; University of Bristol; University of Sydney; Western Sydney University; University of Nottingham; Universitat de Lleida; Ethiopian Institute of Agricultural Research (EIAR); Egyptian Knowledge Bank (EKB); Agricultural Research Center - Egypt; Syngenta; University of Leeds; Agri-Food & Biosciences Institute; Qingdao Agricultural University; University of Novi Sad; Zhejiang A&F University; ICREA; Peking University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Earlham Institute; Egerton University; Huazhong Agricultural University; King Abdullah University of Science & Technology; Chinese Academy of Tropical Agricultural Sciences
• 刊物名称: Nature
• ISSN/ISSBN: 0028-4599
• DOI: 10.1038/s41586-024-07682-9
• 发表日期: 2024-08-22
• 关键词: whole-genome association; bread wheat; hexaploid wheat; crop production; population; DISCOVERY; resistance; r/qtl; array; rht8

摘要

Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by whole-genome re-sequencing of 827 Watkins landraces and 208 modern cultivars and in-depth field evaluation spanning a decade. We found that modern cultivars are derived from two of the seven ancestral groups of wheat and maintain very long-range haplotype integrity. The remaining five groups represent untapped genetic sources, providing access to landrace-specific alleles and haplotypes for breeding. Linkage disequilibrium-based haplotypes and association genetics analyses link Watkins genomes to the thousands of identified high-resolution quantitative trait loci and significant marker-trait associations. Using these structured germplasm, genotyping and informatics resources, we revealed many Watkins-unique beneficial haplotypes that can confer superior traits in modern wheat. Furthermore, we assessed the phenotypic effects of 44,338 Watkins-unique haplotypes, introgressed from 143 prioritized quantitative trait loci in the context of modern cultivars, bridging the gap between landrace diversity and current breeding. This study establishes a framework for systematically utilizing genetic diversity in crop improvement to achieve sustainable food security. Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.