Mineralized collagen plywood contributes to bone autograft performance

• 成果类型: Article
• 署名作者: Robin, Marc; Mouloungui, Elodie; Castillo Dali, Gabriel; Wang, Yan; Saffar, Jean-Louis; Pavon-Djavid, Graciela; Divoux, Thibaut; Manneville, Sebastien; Behr, Luc; Cardi, Delphine; Choudat, Laurence; Giraud-Guille, Marie-Madeleine; Meddahi-Pelle, Anne; Baudimont, Fannie; Colombier, Marie-Laure; Nassif, Nadine
• 署名单位: Universite PSL; College de France; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Ecole Normale Superieure de Lyon (ENS de LYON); Institut Universitaire de France; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bichat-Claude Bernard - APHP; University of Sevilla; Consejo Superior de Investigaciones Cientificas (CSIC); Instituto de Ciencia de Materiales de Sevilla (ICMS-CSIC)
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5865
• DOI: 10.1038/s41586-024-08208-z
• 发表日期: 2024-12-05
• 关键词: i collagen; mechanisms; matrices; calcium; disease; apatite; phases; GROWTH; repair; vitro

摘要

Autologous bone (AB) is the gold standard for bone-replacement surgeries1, despite its limited availability and the need for an extra surgical site. Traditionally, competitive biomaterials for bone repair have focused on mimicking the mineral aspect of bone, as evidenced by the widespread clinical use of bioactive ceramics2. However, AB also exhibits hierarchical organic structures that might substantially affect bone regeneration. Here, using a range of cell-free biomimetic-collagen-based materials in murine and ovine bone-defect models, we demonstrate that a hierarchical hybrid microstructure-specifically, the twisted plywood pattern of collagen and its association with poorly crystallized bioapatite-favourably influences bone regeneration. Our study shows that the most structurally biomimetic material has the potential to stimulate bone growth, highlighting the pivotal role of physicochemical properties in supporting bone formation and offering promising prospects as a competitive bone-graft material. By examining several cell-free biomimetic-collagen-based materials in murine and ovine bone-defect models, the twisted plywood pattern of collagen-based materials is shown to favourably influence bone regeneration and contributes to bone autograft performance.