Applied body-fluid analysis by wearable devices

• 成果类型: Review
• 署名作者: Brasier, Noe; Wang, Joseph; Gao, Wei; Sempionatto, Juliane R.; Dincer, Can; Ates, H. Ceren; Guder, Firat; Olenik, Selin; Schauwecker, Ivo; Schaffarczyk, Dietmar; Vayena, Effy; Ritz, Nicole; Weisser, Maja; Mtenga, Sally; Ghaffari, Roozbeh; Rogers, John A.; Goldhahn, Joerg
• 署名单位: Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California San Diego; California Institute of Technology; University of Freiburg; University of Freiburg; Technical University of Munich; Imperial College London; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Basel; University of Basel; Lucerne Cantonal Hospital; Ifakara Health Institute; University of Basel; Swiss Tropical & Public Health Institute; University of Basel; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5312
• DOI: 10.1038/s41586-024-08249-4
• 发表日期: 2024-12-05
• 页码: 57-68
• 关键词: mouthguard biosensor; chemical sensors; wireless; TECHNOLOGY; adults

摘要

Wearable sensors are a recent paradigm in healthcare, enabling continuous, decentralized, and non- or minimally invasive monitoring of health and disease. Continuous measurements yield information-rich time series of physiological data that are holistic and clinically meaningful. Although most wearable sensors were initially restricted to biophysical measurements, the next generation of wearable devices is now emerging that enable biochemical monitoring of both small and large molecules in a variety of body fluids, such as sweat, breath, saliva, tears and interstitial fluid. Rapidly evolving data analysis and decision-making technologies through artificial intelligence has accelerated the application of wearables around the world. Although recent pilot trials have demonstrated the clinical applicability of these wearable devices, their widespread adoption will require large-scale validation across various conditions, ethical consideration and sociocultural acceptance. Successful translation of wearable devices from laboratory prototypes into clinical tools will further require a comprehensive transitional environment involving all stakeholders. The wearable device platforms must gain acceptance among different user groups, add clinical value for various medical indications, be eligible for reimbursements and contribute to public health initiatives. In this Perspective, we review state-of-the-art wearable devices for body-fluid analysis and their translation into clinical applications, and provide insight into their clinical purpose.