Journal of the American Statistical Association

最新文章

• Prioritizing Autism Risk Genes Using Personalized Graphical Models Estimated From Single-Cell RNA-seq Data AI翻译
  作者：Liu, Jianyu; Wang, Haodong; Sun, Wei; Liu, Yufeng
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; Fred Hutchinson Cancer Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
  摘要：Hundreds of autism risk genes have been reported recently, mainly based on genetic studies where these risk genes have more de novo mutations in autism subjects than healthy controls. However, as a complex disease, autism is likely associated with more risk genes and many of them may not be identifiable through de novo mutations. We hypothesize that more autism risk genes can be identified through their connections with known autism risk genes in personalized gene-gene interaction graphs. We e...
• Semi-Supervised Linear Regression AI翻译
  作者：Azriel, David; Brown, Lawrence D.; Sklar, Michael; Berk, Richard; Buja, Andreas; Zhao, Linda
  作者单位：Technion Israel Institute of Technology; University of Pennsylvania; Stanford University
  摘要：We study a regression problem where for some part of the data we observe both the label variable (Y) and the predictors (X), while for other part of the data only the predictors are given. Such a problem arises, for example, when observations of the label variable are costly and may require a skilled human agent. When the conditional expectation E[Y vertical bar X] is not exactly linear, one can consider the best linear approximation to the conditional expectation, which can be estimated consi...
• Foundations of Statistics for Data Scientists: With R and Python AI翻译
  作者：Horton, Nicholas J.
  作者单位：Amherst College
• Causal Structural Learning on MPHIA Individual Dataset AI翻译
  作者：Bao, Le; Li, Changcheng; Li, Runze; Yang, Songshan
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Dalian University of Technology; Renmin University of China
  摘要：The Population-based HIV Impact Assessment (PHIA) is an ongoing project that conducts nationally representative HIV-focused surveys for measuring national and regional progress toward UNAIDS' 90-90-90 targets, the primary strategy to end the HIV epidemic. We believe the PHIA survey offers a unique opportunity to better understand the key factors that drive the HIV epidemics in the most affected countries in sub-Saharan Africa. In this article, we propose a novel causal structural learning algo...
• Modeling Pregnancy Outcomes Through Sequentially Nested Regression Models AI翻译
  作者：Bi, Xuan; Feng, Long; Li, Cai; Zhang, Heping
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; City University of Hong Kong; St Jude Children's Research Hospital; Yale University
  摘要：The polycystic ovary syndrome (PCOS) is a most common cause of infertility among women of reproductive age. Unfortunately, the etiology of PCOS is poorly understood. Large-scale clinical trials for pregnancy in polycystic ovary syndrome (PPCOS) were conducted to evaluate the effectiveness of treatments. Ovulation, pregnancy, and live birth are three sequentially nested binary outcomes, typically analyzed separately. However, the separate models may lose power in detecting the treatment effects...
• Multiscale Quantile Segmentation AI翻译
  作者：Jula Vanegas, Laura; Behr, Merle; Munk, Axel
  作者单位：University of Gottingen; University of California System; University of California Berkeley; Max Planck Society
  摘要：We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does not rely on any distributional assumption besides serial independence. It is based on a multiscale statistic, which allows to control the (finite sample) probability for selecting the correct number of segments S at a given error level, which serves as a tuning parameter. For a proper choice of this parameter, this prob...
• Large-Scale Datastreams Surveillance via Pattern-Oriented-Sampling AI翻译
  作者：Ren, Haojie; Zou, Changliang; Chen, Nan; Li, Runze
  作者单位：Shanghai Jiao Tong University; Nankai University; Nankai University; National University of Singapore; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Monitoring large-scale datastreams with limited resources has become increasingly important for real-time detection of abnormal activities in many applications. Despite the availability of large datasets, the challenges associated with designing an efficient change-detection when clustering or spatial pattern exists are not yet well addressed. In this article, a design-adaptive testing procedure is developed when only a limited number of streaming observations can be accessed at each time. We ...
• An Empirical Bayes Method for Chi-Squared Data AI翻译
  作者：Du, Lilun; Hu, Inchi
  作者单位：Hong Kong University of Science & Technology
  摘要：In a thought-provoking paper, Efron investigated the merit and limitation of an empirical Bayes method to correct selection bias based on Tweedie's formula first reported in the study by Robbins. The exceptional virtue of Tweedie's formula for the normal distribution lies in its representation of selection bias as a simple function of the derivative of log marginal likelihood. Since the marginal likelihood and its derivative can be estimated from the data directly without invoking prior inform...
• High-Dimensional Mediation Analysis for Selecting DNA Methylation Loci Mediating Childhood Trauma and Cortisol Stress Reactivity AI翻译
  作者：Guo, Xu; Li, Runze; Liu, Jingyuan; Zeng, Mudong
  作者单位：Beijing Normal University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Xiamen University; Xiamen University
  摘要：Childhood trauma tends to influence cortisol stress reactivity through the mediating effects of DNA methylation. Houtepen et al. conducted a study to investigate the role of DNA methylation in cortisol stress reactivity and its relationship with childhood trauma. The study collected a dataset consisting of 385,882 DNA methylation loci, cortisol stress reactivity, one-dimensional score on a childhood trauma questionnaire and several covariates for 85 healthy individuals. Of great scientific int...
• Hierarchical Network Models for Exchangeable Structured Interaction Processes AI翻译
  作者：Dempsey, Walter; Oselio, Brandon; Hero, Alfred
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Network data often arises via a series of structured interactions among a population of constituent elements. E-mail exchanges, for example, have a single sender followed by potentially multiple receivers. Scientific articles, on the other hand, may have multiple subject areas and multiple authors. We introduce a statistical model, termed the Pitman-Yor hierarchical vertex components model (PY-HVCM), that is well suited for structured interaction data. The proposed PY-HVCM effectively models c...