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作者:Bonetti, M; Cole, BF; Gelber, RD
作者单位:Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Dartmouth College; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School
摘要:Quality-of-life outcomes collected during clinical trials often have considerable amounts of missing data, which, if not appropriately accounted for, may lead to bias in inferences. We introduce a method-of-moments (MM) estimating procedure for a model designed to handle nonignorable missingness arising in categorical data measured on independent populations. The missingness mechanism is assumed to be the same across the populations. We derive necessary and sufficient conditions for the identi...
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作者:Théberge, A
作者单位:Statistics Canada
摘要:Estimators from the family of calibration estimators are often used when auxiliary information about a population is available. By viewing calibration as an algebraic problem, this article extends the: calibration technique to estimate population parameters other than totals and means, and also extends the technique to the case where there is no solution to the calibration equation. These extensions permit the development of estimators for small domains that have a synthetic component and yet ...
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作者:Liu, JS; Neuwald, AF; Lawrence, CE
作者单位:Stanford University; Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Wadsworth Center
摘要:The alignment of multiple homologous biopolymer sequences is crucial in research on protein modeling and engineering, molecular evolution, and prediction in terms of both gene function and gene product structure. In this article we provide a coherent view of the two recent models used for multiple sequence alignment-the hidden Markov model (HMM) and the block-based motif model-to develop a set of new algorithms that have both the sensitivity of the block-based model and the flexibility of the ...
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作者:Spiekerman, CF; Lin, DY
作者单位:University of Washington; University of Washington Seattle
摘要:In this article we propose a general Cox-type regression model to formulate the marginal distributions of multivariate failure time data. This model has a nested structure in that it allows different baseline hazard functions among distinct failure types and imposes a common baseline hazard function on the failure times of the same type. We prove that the maximum quasi-partial-likelihood estimator for the vector of regression parameters under the independence working assumption is consistent a...
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作者:Knight, K; Kustra, R; Tibshirani, R
作者单位:University of Toronto; University of Toronto; University of Toronto; University of Toronto
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作者:Baker, SG
作者单位:National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
摘要:Many randomized cancer screening trials involve all-or-none compliance. Some subjects randomized to an offer of screening refuse screening, and some subjects randomized to no offer of screening obtain Screening outside the trial. The primary analysis to test whether or not cancer screening reduces cancer mortality is by intent-to-treat. To estimate the cost-effectiveness of screening, it is necessary to adjust for all-or-none compliance. Heretofore, adjustments for all-or-none compliance have ...
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作者:Li, H; Tsay, RS
作者单位:University of Chicago
摘要:This article proposes a Bayesian procedure for simultaneous identification of the Kronecker indices and model parameters of a multivariate linear system. The model parameters include the starting values and innovations of the system so that the series considered may be co-integrated or non-invertible. The procedure uses some recent developments in stochastic search variable selection in linear regression analysis and Markov chain Monte Carlo methods in statistical computing. It also takes into...
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作者:Montgomery, AL; Zarnowitz, V; Tsay, RS; Tiao, GC
作者单位:University of Pennsylvania; University of Chicago
摘要:This article presents a comparison of forecasting performance for a variety of linear and nonlinear time series models using the U.S. unemployment rate. Our main emphases are on measuring forecasting performance during economic expansions and contractions by exploiting the asymmetric cyclical behavior of unemployment numbers, on building vector models that incorporate initial jobless claims as a leading indicator, and on utilizing additional information provided by the monthly rate for forecas...
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作者:Zucker, DM
作者单位:Hebrew University of Jerusalem
摘要:Karrison has presented a method for covariate-adjusted comparison of two groups with respect to survival when the group effect is expected to not be of proportional hazards form. This article describes a simplified procedure for implementing Karrison's basic approach, along with an extended version designed to achieve robustness against misspecification in the underlying analytical model. A simulation study of these techniques is presented, and the techniques are illustrated with an example ta...
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作者:Hardwick, J; Page, C; Stout, QF
作者单位:Purdue University System; Purdue University; Michigan State University; University of Michigan System; University of Michigan
摘要:To estimate a success probability p, two experiments are available: individual Bernoulli (p) trials or the product of r individual Bernoulli (p) trials. This problem has its roots in reliability where either single components can be tested or a system of r identical components can be rested. A total of N experiments can be performed, and the problem is to sequentially select some combination (allocation) of these two experiments, along with an estimator of p, to achieve low mean squared error ...