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作者:Tan, Zhiqiang
作者单位:Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
摘要:Recent researches in econometrics and statistics have gained considerable insights into the use of instrumental variables (lVs) for causal inference. A basic idea is that IVs serve as an experimental handle, the turning of which may change each individual's treatment status and, through and only through this effect, also change observed outcome. The average difference in observed outcome relative to that in treatment status gives the average treatment effect for those whose treatment status is...
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作者:Chen, Xiaohong; Fan, Yanqin; Tsyrennikov, Viktor
作者单位:New York University; Vanderbilt University
摘要:We propose a sieve maximum likelihood estimation procedure for a broad class of semiparametric multivariate distributions. A joint distribution in this class is characterized by a parametric copula function evaluated at nonparametric marginal distributions. This class of distributions has gained popularity in diverse fields due to its flexibility in separately modeling the dependence structure and the marginal behaviors of a multivariate random variable, and its circumvention of the curse of d...
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作者:Hafner, Christian M.; Linton, Oliver B.
作者单位:University of London; London School Economics & Political Science
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作者:Ho, Daniel E.; Imai, Kosuke
作者单位:Stanford University; Princeton University
摘要:Since the 2000 U.S. Presidential election, social scientists have rediscovered a long tradition of research examining the effects of ballot format on voting. Using a new dataset collected by The New York Times, we investigate the causal effect of being listed on the first ballot page in the 2003 California gubernatorial recall election. California law mandates a unique randomization procedure of ballot order that, when appropriately modeled, can be used to approximate a classical randomized ex...
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作者:Biedermann, Stefanie; Dette, Holger; Zhu, Wei
作者单位:Ruhr University Bochum; State University of New York (SUNY) System; Stony Brook University
摘要:In close-response studies, the dose range is often restricted because of concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a broad class of optimality criteria. The underlying curve belongs to a diversified set of link functions suitable for the dose-response studies and having a common canonical form. These include the fundamental binary response models-the logit ...
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作者:Lu, Guobing; Ades, A. E.
作者单位:University of Bristol
摘要:Randomized comparisons among several treatments give rise to an incomplete-blocks structure known as mixed treatment comparisons (MTCs). To analyze such data structures, it is crucial to assess whether the disparate evidence sources provide consistent information about the treatment contrasts. In this article we propose a general method for assessing evidence inconsistency in the framework of Bayesian hierarchical models. We begin with the distinction between basic parameters, which have prior...
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作者:Heard, NA; Holmes, CC; Stephens, DA
作者单位:Imperial College London; University of Oxford; MRC Harwell
摘要:Malaria represents one of the major worldwide challenges to public health. A recent breakthrough in the study of the disease follows the annotation of the genome of the malaria parasite Plasmodium falciparum and the mosquito vector (an organism that spreads an infectious disease) Anopheles. Of particular interest is the molecular biology underlying the immune response system of Anopheles, which actively fights against Plasmodium infection. This article reports a statistical analysis of gene ex...
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作者:Lin, DY; Zeng, D
作者单位:University of North Carolina; University of North Carolina Chapel Hill
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作者:Zhang, D; Wells, MT; Turnbull, BW; Sparrow, D; Cassano, PA
作者单位:University of Rochester; Cornell University; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Boston University; Cornell University
摘要:There is continued debate regarding the exact relation between lower cholesterol levels and increased respiratory disease mortality. One of the goals of this study is to reveal the relationship between subcomponents of cholesterol and pulmonary function. We consider the subcomponents of total cholesterol, namely high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, to investigate the relationship of cholesterol levels with pulmonary function in a longitudinal study. To ...
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作者:McKeague, IW
作者单位:Columbia University; State University System of Florida; Florida State University
摘要:A Bayesian model for off-line signature verification involving the representation of a signature through its curvature is developed. The prior model makes use of a spatial point process for specifying the knots in an approximation restricted to a buffer region close to a template curvature, along with an independent time-warping mechanism. In this way, prior shape information about the signature can be built into the analysis. The observation model is based on additive white noise superimposed...