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作者：Dette, Holger; Bretz, Frank; Pepelyshev, Andrey; Pinheiro, Jose
作者单位：Ruhr University Bochum; Saint Petersburg State University
摘要：Understanding and properly characterizing the dose-response relationship is a fundamental step in the investigation of a new compound, be it a herbicide or fertilizer, a molecular entity, an environmental toxin, or an industrial chemical. In this article we investigate the problem of deriving efficient designs for the estimation of target doses in the context of clinical dose finding. We propose methods to determine the appropriate number and actual levels of the doses to be administered to pa...
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作者：Gramacy, Robert B.; Lee, Herbert K. H.
作者单位：University of Cambridge; University of California System; University of California Santa Cruz
摘要：Motivated by a computer experiment for the design of a rocket booster this article explores nonstationary modeling methodologies that couple stationary Gaussian processes with treed partioning is a simple but effective method for dealing with nonstationarity. The methodological developments and statistical computing details that make this approach efficient are described in detail. In addition to providing an analysis of the rocket booster, we show that our approach is effective in other areas...
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作者：Chen, Jianwei; Wu, Hulin
作者单位：California State University System; San Diego State University; University of Rochester
摘要：Recently deterministic dynamic models have become very popular in biomedical research and other scientific areas; examples include modeling human immunodeficiency virus (HIV) dynamics, pharmacokinetic/pharmacodynamic analysis, tumor cell kinetics, and genetic network modeling. In this article we propose estimation methods for the time-varying coefficients in deterministic dynamic systems that are usually described by a set of differential equations. Three two-stage local polynomial estimators ...
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作者：Hyrien, Ollivier; Zand, Martin S.
作者单位：University of Rochester; University of Rochester
摘要：Recent advances in flow cytometry have resulted in the development of powerful bioassays to analyze the proliferation of cell populations. The carboxy-fluorescein diacetate succinimidyl ester (CFSE)-labeling experiment is one such assay that is widely used to study cell kinetics and as a standard tool for investigating lymphocyte proliferation. Several mathematical models have been proposed to describe cell proliferation during CFSE experiments. The statistical analysis of CFSE-labeling data h...
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作者：Paciorek, Christopher J.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health
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作者：Stigler, Stephen M.
作者单位：University of Chicago
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作者：Lidong, E.; Hannig, Jan; Iyer, Hari
作者单位：Colorado State University System; Colorado State University Fort Collins
摘要：In this article we propose a new method for constructing confidence intervals for sigma(2)(alpha), sigma(2)(epsilon), and the interclass correlation rho = sigma(2)(alpha)/(sigma(2)(alpha)+sigma(2)(epsilon)) in a two-component mixed-effects linear model. This method is based on an extension of R. A. Fisher's fiducial argument. We conducted a simulation study to compare the resulting interval estimates with other competing confidence interval procedures from the literature. Our results demonstra...
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作者：Dasgupta, Tirthankar; Ma, Christopher; Joseph, V. Roshan; Wang, Z. L.; Wu, C. F. Jeff
作者单位：Harvard University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
摘要：We systematically investigate the best process conditions that ensure synthesis of different types of one-dimensional cadmium selenide nanostructures with high yield and reproducibility. Through a designed experiment and rigorous statistical analysis of experimental data, models linking the probabilities of obtaining specific morphologies to the process variables are developed. A new iterative algorithm for fitting a multinomial generalized linear model is proposed and used. The optimum proces...
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作者：Kaziska, David; Srivastava, Anuj
作者单位：Air Force Institute of Technology (AFIT); United States Department of Defense; United States Air Force; US Air Force Research Laboratory; State University System of Florida; Florida State University
摘要：We study the problem of analyzing and classifying human gait by modeling it as a stochastic process on a shape space. We consider gait as a evolution of human silhouettes as seen in video sequences, and focus on their shapes. More specifically, we define a shape space of planar, closed curves and model a human gait as a stochastic process on this space. Due to the periodic nature of human walk, this process is naturally constrained to be cyclostationary, that is, its mean path is assumed to be...
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作者：Hallin, Marc; Saidi, Abdessamad
作者单位：Universite Libre de Bruxelles; Universite de Montreal
摘要：The problem of testing noncorrelation between two multivariate time series is considered. Assuming that the global process admits a joint vector autoregressive (VAR) representation, noncorrelation between the two component series is equivalent to the hypothesis that all off-diagonal blocks in the matrix coefficients and the innovation covariance of the joint VAR representation are zero. We establish an adequate local asymptotic normality (LAN) property for this VAR model in the vicinity of non...
