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作者：Janson, Lucas; Rajaratnam, Bala
作者单位：Stanford University; Stanford University; Stanford University
摘要：Great strides have been made in the field of reconstructing past temperatures based on models relating temperature to temperature-sensitive paleoclimate proxies. One of the goals of such reconstructions is to assess if current climate is anomalous in a millennial context. These regression-based approaches model the conditional mean of the temperature distribution as a function of paleoclimate proxies (or vice versa). Some of the recent focus in the area has considered methods that help reduce ...
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作者：Jung, Yoonsuh; Huang, Jianhua Z.; Hu, Jianhua
作者单位：University of Waikato; Texas A&M University System; Texas A&M University College Station; Capital University of Economics & Business; University of Texas System; UTMD Anderson Cancer Center
摘要：In genome-wide association studies, the primary task is to detect biomarkers in the form of single nucleotide polymorphisms (SNPs) that have nontrivial associations with a disease phenotype and some other important clinical/environmental factors. However, the extremely large number of SNPs compared to the sample size inhibits application of classical methods such as the multiple logistic regression. Currently, the most commonly used approach is still to analyze one SNP at a time. In this artic...
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作者：Plumlee, Matthew
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：Random field models have been widely employed to develop a predictor of an expensive function based on observations from an experiment. The traditional framework for developing a predictor with random field models can fail due to the computational burden it requires. This problem is often seen in cases where the input of the expensive function is high dimensional. While many previous works have focused on developing an approximative predictor to resolve these issues, this article investigates ...
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作者：Wang, Lan; Sherwood, Ben; Li, Runze
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
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作者：Rockova, Veronika; George, Edward I.
作者单位：University of Pennsylvania
摘要：Despite rapid developments in stochastic search algorithms, the practicality of Bayesian variable selection methods has continued to pose challenges. High-dimensional data are now routinely analyzed, typically with many more covariates than observations. To broaden the applicability of Bayesian variable selection for such high-dimensional linear regression contexts, we propose EMVS, a deterministic alternative to stochastic search based on an EM algorithm which exploits a conjugate mixture pri...
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作者：Matteson, David S.; James, Nicholas A.
作者单位：Cornell University; Cornell University
摘要：Change point analysis has applications in a wide variety of fields. The general problem concerns the inference of a change in distribution for a set of time-ordered observations. Sequential detection is an online version in which new data are continually arriving and are analyzed adaptively. We are concerned with the related, but distinct, offline version, in which retrospective analysis of an entire sequence is performed. For a set of multivariate observations of arbitrary dimension, we consi...
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作者：Parast, Layla; Tian, Lu; Cai, Tianxi
作者单位：RAND Corporation; Stanford University; Harvard University
摘要：In many studies with a survival outcome, it is often not feasible to fully observe the primary event of interest. This often leads to heavy censoring and thus, difficulty in efficiently estimating survival or comparing survival rates between two groups. In certain diseases, baseline covariates and the event time of nonfatal intermediate events may be associated with overall survival. In these settings, incorporating such additional information may lead to gains in efficiency in estimation of s...
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作者：Stroud, Jonathan R.; Johannes, Michael S.
作者单位：George Washington University; Columbia University
摘要：This article estimates models of high-frequency index futures returns using around-the-clock 5-min returns that incorporate the following key features: multiple persistent stochastic volatility factors, jumps in prices and volatilities, seasonal components capturing time of the day patterns, correlations between return and volatility shocks, and announcement effects. We develop an integrated MCMC approach to estimate interday and intraday parameters and states using high-frequency data without...
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作者：Han, Peisong
作者单位：University of Waterloo
摘要：Doubly robust estimators are widely used in missing-data analysis. They provide double protection on estimation consistency against model misspecifications. However, they allow only a single model for the missingness mechanism and a single model for the data distribution, and the assumption that one of these two models is correctly specified is restrictive in practice. For regression analysis with possibly missing outcome, we propose an estimation method that allows multiple models for both th...
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作者：Thall, Peter F.; Nguyen, Hoang Q.; Zohar, Sarah; Maton, Pierre
作者单位：University of Texas System; UTMD Anderson Cancer Center; Sorbonne Universite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
摘要：The intubation-surfactant-extubation (INSURE) procedure is used worldwide to treat preterm newborn infants suffering from respiratory distress syndrome, which is caused by an insufficient amount of the chemical surfactant in the lungs. With INSURE, the infant is intubated, surfactant is administered via the tube to the trachea, and at completion the infant is extubated. This improves the infant's ability to breathe and thus decreases the risk of long-term neurological or motor disabilities. To...
