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作者:Li, Chunlin; Shen, Xiaotong; Pan, Wei
作者单位:University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要:Inference of directional pairwise relations between interacting units in a directed acyclic graph (DAG), such as a regulatory gene network, is common in practice, imposing challenges because of lack of inferential tools. For example, inferring a specific gene pathway of a regulatory gene network is biologically important. Yet, frequentist inference of directionality of connections remains largely unexplored for regulatory models. In this article, we propose constrained likelihood ratio tests f...
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作者:Smith, Adam N.; Allenby, Greg M.
作者单位:University of London; University College London; University System of Ohio; Ohio State University
摘要:Many economic models of consumer demand require researchers to partition sets of products or attributes prior to the analysis. These models are common in applied problems when the product space is large or spans multiple categories. While the partition is traditionally fixed a priori, we let the partition be a model parameter and propose a Bayesian method for inference. The challenge is that demand systems are commonly multivariate models that are not conditionally conjugate with respect to pa...
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作者:Katzfuss, Matthias; Stroud, Jonathan R.; Wikle, Christopher K.
作者单位:Texas A&M University System; Texas A&M University College Station; Georgetown University; University of Missouri System; University of Missouri Columbia
摘要:We propose a new class of filtering and smoothing methods for inference in high-dimensional, nonlinear, non-Gaussian, spatio-temporal state-space models. The main idea is to combine the ensemble Kalman filter and smoother, developed in the geophysics literature, with state-space algorithms from the statistics literature. Our algorithms address a variety of estimation scenarios, including online and off-line state and parameter estimation. We take a Bayesian perspective, for which the goal is t...
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作者:Lee, Clement; Wilkinson, Darren J.
作者单位:Newcastle University - UK; Newcastle University - UK; Alan Turing Institute
摘要:We present a hierarchical model of nonhomogeneous Poisson processes (NHPP) for information diffusion on online social media, in particular Twitter retweets. The retweets of each original tweet are modelled by a NHPP, for which the intensity function is a product of time-decaying components and another component that depends on the follower count of the original tweet author. The latter allows us to explain or predict the ultimate retweet count by a network centrality-related covariate. The inf...
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作者:Wilson, Douglas R.; Jin, Chong; Ibrahim, Joseph G.; Sun, Wei
作者单位:University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle
摘要:Immunotherapies have attracted lots of research interests recently. The need to understand the underlying mechanisms of immunotherapies and to develop precision immunotherapy regimens has spurred great interest in characterizing immune cell composition within the tumor microenvironment. Several methods have been developed to estimate immune cell composition using gene expression data from bulk tumor samples. However, these methods are not flexible enough to handle aberrant patterns of gene exp...
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作者:Bharath, Karthik; Kurtek, Sebastian
作者单位:University of Nottingham; University System of Ohio; Ohio State University
摘要:Alignment of curve data is an integral part of their statistical analysis, and can be achieved using model- or optimization-based approaches. The parameter space is usually the set of monotone, continuous warp maps of a domain. Infinite-dimensional nature of the parameter space encourages sampling based approaches, which require a distribution on the set of warp maps. Moreover, the distribution should also enable sampling in the presence of important landmark information on the curves which co...
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作者:Mejia, Amanda F.; Yue, Yu (Ryan); Bolin, David; Lindgren, Finn; Lindquist, Martin A.
作者单位:Indiana University System; Indiana University Bloomington; City University of New York (CUNY) System; Baruch College (CUNY); Chalmers University of Technology; University of Gothenburg; University of Edinburgh; Johns Hopkins University
摘要:Cortical surface functional magnetic resonance imaging (cs-fMRI) has recently grown in popularity versus traditional volumetric fMRI. In addition to offering better whole-brain visualization, dimension reduction, removal of extraneous tissue types, and improved alignment of cortical areas across subjects, it is also more compatible with common assumptions of Bayesian spatial models. However, as no spatial Bayesian model has been proposed for cs-fMRI data, most analyses continue to employ the c...
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作者:Wang, Wenjia; Tuo, Rui; Wu, C. F. Jeff
作者单位:Texas A&M University System; Texas A&M University College Station; University System of Georgia; Georgia Institute of Technology
摘要:Kriging based on Gaussian random fields is widely used in reconstructing unknown functions. The kriging method has pointwise predictive distributions which are computationally simple. However, in many applications one would like to predict for a range of untried points simultaneously. In this work, we obtain some error bounds for the simple and universal kriging predictor under the uniform metric. It works for a scattered set of input points in an arbitrary dimension, and also covers the case ...
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作者:Javadi, Hamid; Montanari, Andrea
作者单位:Rice University; Stanford University
摘要:Given a collection of data points, nonnegative matrix factorization (NMF) suggests expressing them as convex combinations of a small set of archetypes with nonnegative entries. This decomposition is unique only if the true archetypes are nonnegative and sufficiently sparse (or the weights are sufficiently sparse), a regime that is captured by the separability condition and its generalizations. In this article, we study an approach to NMF that can be traced back to the work of Cutler and Breima...
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作者:Yu, Bin; Barter, Rebecca
作者单位:University of California System; University of California Berkeley; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)