6636期

最新文章

• Astronomy pioneer might have been near-sighted AI翻译
  作者：Brainard, Jeffrey
• Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase AI翻译
  作者：Hicks, Kevin G.; Cluntun, Ahmad A.; Schubert, Heidi L.; Hackett, Sean R.; Berg, Jordan A.; Leonard, Paul G.; Aleixo, Mariana A. Ajalla; Zhou, Youjia; Bott, Alex J.; Salvatore, Sonia R.; Chang, Fei; Blevins, Aubrie; Barta, Paige; Tilley, Samantha; Leifer, Aaron; Guzman, Andrea; Arok, Ajak; Fogarty, Sarah; Winter, Jacob M.; Ahn, Hee-Chul; Allen, Karen N.; Block, Samuel; Cardoso, Iara A.; Ding, Jianping; Dreveny, Ingrid; Gasper, William C.; Ho, Quinn; Matsuura, Atsushi; Palladino, Michael J.; Prajapati, Sabin; Sun, Pengkai; Tittmann, Kai; Tolan, Dean R.; Unterlass, Judith; VanDemark, Andrew P.; Vander Heiden, Matthew G.; Webb, Bradley A.; Yun, Cai-Hong; Zhao, Pengkai; Wang, Bei; Schopter, Francisco J.; Hill, Christopher P.; Nonato, Maria Cristina; Muller, Florian L.; Cox, James E.; Rutter, Jared
  作者单位：Utah System of Higher Education; University of Utah; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Universidade de Sao Paulo; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Howard Hughes Medical Institute; Utah System of Higher Education; University of Utah; Dongguk University; Boston University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Center for Excellence in Molecular Cell Science, CAS; University of Nottingham; Boston University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Gottingen; Max Planck Society; Karolinska Institutet; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; West Virginia University; Peking University; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Southwestern Medical Center; Scripps Research Institute; Baylor University
  摘要：Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the discovery of allostery systematically (MIDAS) to identify such interactions. Analysis of 33 enzymes from human carbohydrate metabolism identified 830 protein-metabolite interactions, including known regulat...
• AI tools can improve equity in science AI翻译
  作者：Berdejo-Espinola, Violeta; Amano, Tatsuya
  作者单位：University of Queensland; University of Queensland
• Origin of life group debuts AI翻译
  作者：Brainard, Jeffrey
• Editor's note AI翻译
  作者：Thorp, H. Holden; Vinson, Valda
• Direct observation of motor protein stepping in living cells using MINFLUX AI翻译
  作者：Deguchi, Takahiro; Iwanski, Malina K.; Schentarra, Eva-Maria; Heidebrecht, Christopher; Schmidt, Lisa; Heck, Jennifer; Weihs, Tobias; Schnorrenberg, Sebastian; Hoess, Philipp; Liu, Sheng; Chevyreva, Veronika; Noh, Kyung-Min; Kapitein, Lukas C.; Ries, Jonas
  作者单位：European Molecular Biology Laboratory (EMBL); Utrecht University; Ruprecht Karls University Heidelberg; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); University of New Mexico; IFOM - FIRC Institute of Molecular Oncology
  摘要：Dynamic measurements of molecular machines can provide invaluable insights into their mechanism, but these measurements have been challenging in living cells. Here, we developed live-cell tracking of single fluorophores with nanometer spatial and millisecond temporal resolution in two and three dimensions using the recently introduced super-resolution technique MINFLUX. Using this approach, we resolved the precise stepping motion of the motor protein kinesin-1 as it walked on microtubules in l...
• Protect Earth's orbit: Avoid high seas mistakes AI翻译
  作者：Napper, Imogen E.; Davies, Alasdair J.; Jah, Moriba; Miner, Kimberley R.; Thompson, Richard C.; Quinn, Melissa; Koldewey, Heather J.
  作者单位：University of Plymouth; University of Texas System; University of Texas Austin; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; Zoological Society of London
• Words yes, actions unlikely AI翻译
  作者：Thorp, H. Holden
• Canadians left in the cold by dwindling weather data Unreliable snow records also threaten climate projections AI翻译
  作者：Voosen, Paul
• SOCIAL LEARNING Social signal learning of the waggle dance in honey bees AI翻译
  作者：Dong, Shihao; Lin, Tao; Nieh, James C.; Tan, Ken
  作者单位：Chinese Academy of Sciences; Xishuangbanna Tropical Botanical Garden, CAS; University of California System; University of California San Diego
  摘要：Honey bees use a complex form of spatial referential communication. Their waggle dance communicates the direction, distance, and quality of a resource to nestmates by encoding celestial cues, retinal optic flow, and relative food value into motion and sound within the nest. We show that correct waggle dancing requires social learning. Bees without the opportunity to follow any dances before they first danced produced significantly more disordered dances with larger waggle angle divergence erro...