作者：Zhai, Yue; Chen, Liang; Zhao, Qian; Zheng, Zhao-Hui; Chen, Zhi-Nan; Bian, Huijie; Yang, Xu; Lu, Huan-Yu; Lin, Peng; Chen, Xi; Chen, Ruo; Sun, Hao-Yang; Fan, Lin-Ni; Zhang, Kun; Wang, Bin; Sun, Xiu-Xuan; Feng, Zhuan; Zhu, Yu-Meng; Zhou, Jian-Sheng; Chen, Shi-Rui; Zhang, Tao; Chen, Si-Yu; Chen, Jun-Jie; Zhang, Kui; Wang, Yan; Chang, Yang; Zhang, Rui; Zhang, Bei; Wang, Li-Juan; Li, Xiao-Min; He, Qian; Yang, Xiang-Min; Nan, Gang; Xie, Rong-Hua; Yang, Liu; Yang, Jing-Hua; Zhu, Ping
作者单位：Air Force Medical University; Air Force Medical University; Shanghai University; Zhengzhou University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University
摘要：Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, we identified a panel of cysteine residues differentially modified by carboxyethylation that required 3-hydroxypropionic acid to generate neoantigens in patients with AS. The lysosomal degradation of integrin aIIb [ITGA2B (CD41)] carboxyethy...
