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作者：Brainard, Jeffrey
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作者：Mukadam, Aamir S.; Miller, Lauren V. C.; Smith, Annabel E.; Vaysburd, Marina; Sakya, Siri A.; Sanford, Sophie; Keeling, Sophie; Tuck, Benjamin J.; Katsinelos, Taxiarchis; Green, Chris; Skov, Lise; Kaalund, Sanne S.; Foss, Stian; Mayes, Keith; 'Connell, Kevin; Wing, Mark; Knox, Claire; Banbury, Jessica; Avezov, Edward; Rowe, James B.; Goedert, Michel; Andersen, Jan Terje; James, Leo C.; McEwan, William A.
作者单位：University of Cambridge; MRC Laboratory Molecular Biology; University of Oslo; University of Oslo; National Hospital Norway; University of Oslo; University of Oslo; University of Oslo; University of Cambridge; University of Copenhagen; Bispebjerg Hospital
摘要：Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. Tau can be targeted by using passively transferred antibodies (Abs), but the mechanisms of Ab protection are incompletely understood. In this work, we used a variety of cell and animal model systems and showed that the cytosolic Ab receptor and E3 ligase TRIM21 (T21) could play a role in Ab protection against tau pathology. Tau-Ab complexes were internalized to the cytosol of neurons, which enabled ...
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作者：Cullen, Thomas M.; Larson, Derek W.; Witton, Mark P.; Scott, Diane; Maho, Tea; Brink, Kirstin S.; Evans, David C.; Reisz, Robert
作者单位：Auburn University System; Auburn University; University of Ottawa; Carleton University; Field Museum of Natural History (Chicago); University of Toronto; University of Portsmouth; Jilin University; Jilin University; University of Toronto; University Toronto Mississauga; University of Manitoba; Royal Ontario Museum
摘要：Large theropod dinosaurs are often reconstructed with their marginal dentition exposed because of the enormous size of their teeth and their phylogenetic association to crocodylians. We tested this hypothesis using a multiproxy approach. Regressions of skull length and tooth size for a range of theropods and extant varanid lizards confirm that complete coverage of theropod dinosaur teeth with extraoral tissues (gingiva and labial scales) is both plausible and consistent with patterns observed ...
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作者：Yu, Tianhao; Cui, Haiyang; Li, Jianan Canal; Luo, Yunan; Jiang, Guangde; Zhao, Huimin
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Cornell University; University System of Georgia; Georgia Institute of Technology; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Enzyme function annotation is a fundamental challenge, and numerous computational tools have been developed. However, most of these tools cannot accurately predict functional annotations, such as enzyme commission (EC) number, for less-studied proteins or those with previously uncharacterized functions or multiple activities. We present a machine learning algorithm named CLEAN (contrastive learning-enabled enzyme annotation) to assign EC numbers to enzymes with better accuracy, reliability, an...
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作者：Nisbet, Rebecca M.
作者单位：Florey Institute of Neuroscience & Mental Health; University of Melbourne
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Dunn, Rob
作者单位：North Carolina State University; North Carolina State University
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作者：Kinoshita, N.; Paul, M.; Kashiv, Y.; Collon, P.; Deibel, C. M.; DiGiovine, B.; Greene, J. P.; Jiang, C. L.; Marley, S. T.; Pardo, R. C.; Rehm, K. E.; Robertson, D.; Scott, R.; Schmitt, C.; Tang, X. D.; Vondrasek, R.; Yokoyama, A.
作者单位：Hebrew University of Jerusalem; University of Notre Dame; Louisiana State University System; Louisiana State University; United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; Chinese Academy of Sciences; Institute of Modern Physics, CAS; Kanazawa University
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作者：Brainard, Jeffrey
