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• Direct imaging and astrometric detection of a gas giant planet orbiting an accelerating star AI翻译
  作者：Currie, Thayne; Brandt, Mirek; Brandt, Timothy D.; Lacy, Brianna; Burrows, Adam; Guyon, Olivier; Tamura, Motohide; Liu, Ranger Y.; Sagynbayeva, Sabina; Tobin, Taylor; Chilcote, Jeffrey; Groff, Tyler; Marois, Christian; Thompson, William; Murphy, Simon J.; Kuzuhara, Masayuki; Lawson, Kellen; Lozi, Julien; Deo, Vincent; Vievard, Sebastien; Skaf, Nour; Uyama, Taichi; Jovanovic, Nemanja; Martinache, Frantz; Kasdin, N. Jeremy; Kudo, Tomoyuki; McElwain, Michael; Janson, Markus; Wisniewski, John; Hodapp, Klaus; Nishikawa, Jun; Helminiak, Krzysztof; Kwon, Jungmi; Hayashi, Masahiko
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); University of Texas System; University of Texas at San Antonio; Eureka Scientific; University of California System; University of California Santa Barbara; Princeton University; University of Texas System; University of Texas Austin; National Institutes of Natural Sciences (NINS) - Japan; Astrobiology Center (ABC); University of Arizona; National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); University of Tokyo; Columbia University; State University of New York (SUNY) System; Stony Brook University; University of Notre Dame; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Research Council Canada; University of Victoria; University of Sydney; University of Southern Queensland; California Institute of Technology; California Institute of Technology; Universite Cote d'Azur; Observatoire de la Cote d'Azur; Princeton University; Stockholm University; George Mason University; University of Hawaii System; University Hawaii Hilo; Polish Academy of Sciences; Nicolaus Copernicus Astronomical Center of the Polish Academy of Sciences; University of Michigan System; University of Michigan
  摘要：Direct imaging of gas giant exoplanets provides information on their atmospheres and the architectures of planetary systems. However, few planets have been detected in blind surveys with direct imaging. Using astrometry from the Gaia and Hipparcos spacecraft, we identified dynamical evidence for a gas giant planet around the nearby star HIP 99770. We confirmed the detection of this planet with direct imaging using the Subaru Coronagraphic Extreme Adaptive Optics instrument. The planet, HIP 997...
• Barriers to progress in pregnancy research How can we break through AI翻译
  作者：Stock, Sarah J.; Aiken, Catherine E.
  作者单位：University of Edinburgh; University of Edinburgh; University of Cambridge; University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge
  摘要：Healthy pregnancies are fundamental to healthy populations, but very few therapies to improve pregnancy outcomes are available. Fundamental concepts-for example, placentation or the mechanisms that control the onset of labor-remain understudied and incompletely understood. A key issue is that research efforts must capture the complexity of the tripartite maternal-placental-fetal system, the dynamics of which change throughout gestation. Studying pregnancy disorders is complicated by the diffic...
• Mechanical nonreciprocity in a uniform composite material AI翻译
  作者：Wang, Xiang; Li, Zhihao; Wang, Shuxu; Sano, Koki; Sun, Zhifang; Shao, Zhenhua; Takeishi, Asuka; Matsubara, Seishiro; Okumura, Dai; Sakai, Nobuyuki; Sasaki, Takayoshi; Aida, Takuzo; Ishida, Yasuhiro
  作者单位：RIKEN; University of Tokyo; RIKEN; RIKEN; Nagoya University; National Institute for Materials Science; Shinshu University
  摘要：Mechanical nonreciprocity, or the asymmetric transmission of mechanical quantities between two points in space, is crucial for developing systems that can guide, damp, and control mechanical energy. We report a uniform composite hydrogel that displays substantial mechanical nonreciprocity, owing to direction-dependent buckling of embedded nanofillers. This material exhibits an elastic modulus more than 60 times higher when sheared in one direction compared with the opposite direction. Conseque...
• Genentech finds no fraud inquiry AI翻译
  作者：Brainard, Jeffrey
• The origins and functional effects of postzygotic mutations throughout the human life span AI翻译
  作者：Rockweiler, Nicole B.; Ramu, Avinash; Nagirnaja, Liina; Wong, Wing H.; Noordam, Michiel J.; Drubin, Casey W.; Huang, Ni; Miller, Brian; Todres, Ellen Z.; Vigh-Conrad, Katinka A.; Zito, Antonino; Small, Kerrin S.; Ardlie, Kristin G.; Cohen, Barak A.; Conrad, Donald F.
  作者单位：Washington University (WUSTL); Oregon Health & Science University; Oregon National Primate Research Center; Washington University (WUSTL); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; King's College London; Oregon Health & Science University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Stanford University; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Postzygotic mutations (PZMs) begin to accrue in the human genome immediately after fertilization, but how and when PZMs affect development and lifetime health remain unclear. To study the origins and functional consequences of PZMs, we generated a multitissue atlas of PZMs spanning 54 tissue and cell types from 948 donors. Nearly half the variation in mutation burden among tissue samples can be explained by measured technical and biological effects, and 9% can be attributed to donor-specific e...
• US reboots coronavirus research AI翻译
  作者：Brainard, Jeffrey
• Storied accelerator to test chips AI翻译
  作者：Brainard, Jeffrey
• The evolution of hominoid locomotor versatility: Evidence from Moroto, a 21 Ma site in Uganda AI翻译
  作者：MacLatchy, Laura M.; Cote, Susanne M.; Deino, Alan L.; Kityo, Robert M.; Mugume, Amon A. T.; Rossie, James B.; Sanders, William J.; Cosman, Miranda N.; Driese, Steven G.; Fox, David L.; Freeman, April J.; Jansma, Rutger J. W.; Jenkins, Kirsten E. H.; Kinyanjui, Rahab N.; Lukens, William E.; McNulty, Kieran P.; Novello, Alice; Peppe, Daniel J.; Stromberg, Caroline A. E.; Uno, Kevin T.; Winkler, Alisa J.; Kingston, John D.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Calgary; Berkeley Geochronolgy Center; Makerere University; State University of New York (SUNY) System; Stony Brook University; Baylor University; University of Minnesota System; University of Minnesota Twin Cities; Arizona State University; Arizona State University-Tempe; Max Planck Society; Smithsonian Institution; Smithsonian National Museum of Natural History; James Madison University; University of Minnesota System; University of Minnesota Twin Cities; Institut de Recherche pour le Developpement (IRD); Universite PSL; College de France; Centre National de la Recherche Scientifique (CNRS); INRAE; Aix-Marseille Universite; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Columbia University; Southern Methodist University; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Living hominoids are distinguished by upright torsos and versatile locomotion. It is hypothesized that these features evolved for feeding on fruit from terminal branches in forests. To investigate the evolutionary context of hominoid adaptive origins, we analyzed multiple paleoenvironmental proxies in conjunction with hominoid fossils from the Moroto II site in Uganda. The data indicate seasonally dry woodlands with the earliest evidence of abundant C4 grasses in Africa based on a confirmed ag...
• Understanding the genetics of human infertility AI翻译
  作者：Sang, Qing; Ray, Pierre F.; Wang, Lei
  作者单位：Fudan University; Fudan University; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：Reproduction involves a wide range of biological processes, including organ formation and development, neuroendocrine regulation, hormone production, and meiosis and mitosis. Infertility, the failure of reproduction, has become a major issue for human reproductive health and affects up to one in seven couples worldwide. Here, we review various aspects of human infertility, including etiology, mechanisms, and treatments, with a particular emphasis on genetics. We focus on gamete production and ...