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作者：Morris, John A.; Caragine, Christina; Daniloski, Zharko; Domingo, Julia; Barry, Timothy; Lu, Lu; Davis, Kyrie; Ziosi, Marcello; Glinos, Dafni A.; Hao, Stephanie; Mimitou, Eleni P.; Smibert, Peter; Roeder, Kathryn; Katsevich, Eugene; Lappalainen, Tuuli; Sanjana, Neville E.
摘要：Most variants associated with complex traits and diseases identified by genome-wide association studies (GWAS) map to noncoding regions of the genome with unknown effects. Using ancestrally diverse, biobank-scale GWAS data, massively parallel CRISPR screens, and single-cell transcriptomic and proteomic sequencing, we discovered 124 cis-target genes of 91 noncoding blood trait GWAS loci. Using precise variant insertion through base editing, we connected specific variants with gene expression ch...
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作者：Brainard, Jeffrey
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作者：Prugh, Laura R.; Cunningham, Calum X.; Windell, Rebecca M.; Kertson, Brian N.; Ganz, Taylor R.; Walker, Savanah L.; Wirsing, Aaron J.
作者单位：University of Washington; University of Washington Seattle; Washington Department of Fish & Wildlife (WDFW)
摘要：The challenge that large carnivores face in coexisting with humans calls into question their ability to carry out critical ecosystem functions such as mesopredator suppression outside protected areas. In this study, we examined the movements and fates of mesopredators and large carnivores across rural landscapes characterized by substantial human influences. Mesopredators shifted their movements toward areas with twofold-greater human influence in regions occupied by large carnivores, indicati...
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作者：Ridente, Enrico; Hait, Diptarka; Haugen, Eric A.; Ross, Andrew D.; Neumark, Daniel M.; Head-Gordon, Martin; Leone, Stephen R.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Stanford University; Stanford University
摘要：Understanding the relaxation pathways of photoexcited molecules is essential to gain atomistic-level insight into photochemistry. We performed a time-resolved study of ultrafast molecular symmetry breaking through geometric relaxation (Jahn-Teller distortion) on the methane cation. Attosecond transient absorption spectroscopy with soft x-rays at the carbon K-edge revealed that the distortion occurred within 10 +/- 2 femtoseconds after few-femtosecond strong-field ionization of methane. The dis...
