作者:Cui, Yifan; Gong, Ruobin; Hannig, Jan; Hoffman, Kentaro
作者单位:Zhejiang University; Rutgers University System; Rutgers University New Brunswick; University of North Carolina; University of North Carolina Chapel Hill
摘要:Steed et al. (1) illustrates the crucial impact that the quality of official statistical data products may exert on the accuracy, stability, and equity of policy decisions on which they are based. The authors remind us that data, however responsibly curated, can be fallible. With this comment, we underscore the importance of conducting principled quality assessment of official statistical data products. We observe that the quality assessment procedure employed by Steed et al. needs improvement...
作者:Yang, Kyungae; Mitchell, Noelle M.; Banerjee, Saswata; Cheng, Zhenzhuang; Taylor, Steven; Kostic, Aleksandra M.; Wong, Isabel; Sajjath, Sairaj; Zhang, Yameng; Stevens, Jacob; Mohan, Sumit; Landry, Donald W.; Worgall, Tilla S.; Andrews, Anne M.; Stojanovic, Milan N.
作者单位:NewYork-Presbyterian Hospital; Columbia University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; NewYork-Presbyterian Hospital; Columbia University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; NewYork-Presbyterian Hospital; Columbia University; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Howard Hughes Medical Institute; Rockefeller University; California Institute of Technology
摘要:Aptameric receptors are important biosensor components, yet our ability to identify them depends on the target structures. We analyzed the contributions of individual functional groups on small molecules to binding within 27 target-aptamer pairs, identifying potential hindrances to receptor isolation-for example, negative cooperativity between sterically hindered functional groups. To increase the probability of aptamer isolation for important targets, such as leucine and voriconazole, for whi...
作者:Fieseler, Clare
作者单位:Smithsonian Institution; Smithsonian National Museum of Natural History