作者：Pierre, Joseph F.; Peters, Brian M.; La Torre, Diana; Sidebottom, Ashley M.; Tao, Yun; Zhu, Xiaorong; Cham, Candace M.; Wang, Ling; Kambal, Amal; Harris, Katharine G.; Silva, Julian F.; Zaborina, Olga; Alverdy, John C.; Herzog, Herbert; Witchley, Jessica; Noble, Suzanne M.; Leone, Vanessa A.; Chang, Eugene B.
作者单位：University of Chicago; University of Wisconsin System; University of Wisconsin Madison; University of Tennessee System; University of Tennessee Health Science Center; University of Chicago; Garvan Institute of Medical Research; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of Wisconsin System; University of Wisconsin Madison
摘要：The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY1-36), but not endocrine PYY3-36, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it ...
作者：Yang, Hong; Xiang, Xiaohua; Wu, Xiaoling; Thompson, Julian R.; Flower, Roger J.
作者单位：University of Reading; Hohai University; University of London; University College London
