6674期

最新文章

• Boryl radical catalysis enables asymmetric radical cycloisomerization reactions AI翻译
  作者：Wang, Chang-Ling; Wang, Jie; Jin, Ji-Kang; Li, Bin; Phang, Yee Lin; Zhang, Feng-Lian; Ye, Tian; Xia, Hui-Min; Hui, Li-Wen; Su, Ji-Hu; Fu, Yao; Wang, Yi-Feng
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Nankai University
  摘要：The development of functionally distinct catalysts for enantioselective synthesis is a prominent yet challenging goal of synthetic chemistry. In this work, we report a family of chiral N-heterocyclic carbene (NHC)-ligated boryl radicals as catalysts that enable catalytic asymmetric radical cycloisomerization reactions. The radical catalysts can be generated from easily prepared NHC-borane complexes, and the broad availability of the chiral NHC component provides substantial benefits for stereo...
• Build capacity for climate action AI翻译
  作者：Klinsky, Sonja; Sagar, Ambuj
  作者单位：Arizona State University; Arizona State University-Tempe; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi
• Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly AI翻译
  作者：Shi, Xiaojun; Lingerak, Ryan; Herting, Cameron J.; Ge, Yifan; Kim, Soyeon; Toth, Paul; Wang, Wei; Brown, Benjamin P.; Meiler, Jens; Sossey-Alaoui, Khalid; Buck, Matthias; Himanen, Juha; Hambardzumyan, Dolores; Nikolov, Dimitar B.; Smith, Adam W.; Wang, Bingcheng
  作者单位：MetroHealth System; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Emory University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University System of Ohio; University of Akron; Vanderbilt University; University System of Ohio; Case Western Reserve University; Memorial Sloan Kettering Cancer Center; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University System of Ohio; Case Western Reserve University
  摘要：Ephrin type-A receptor 2 (EphA2) is a receptor tyrosine kinase that initiates both ligand-dependent tumor-suppressive and ligand-independent oncogenic signaling. We used time-resolved, live-cell fluorescence spectroscopy to show that the ligand-free EphA2 assembles into multimers driven by two types of intermolecular interactions in the ectodomain. The first type entails extended symmetric interactions required for ligand-induced receptor clustering and tumor-suppressive signaling that inhibit...
• Two teosintes made modern maize AI翻译
  作者：Yang, Ning; Wang, Yuebin; Liu, Xiangguo; Jin, Minliang; Vallebueno-Estrada, Miguel; Calfee, Erin; Chen, Lu; Dilkes, Brian P.; Gui, Songtao; Fan, Xingming; Harper, Thomas K.; Kennett, Douglas J.; Li, Wenqiang; Lu, Yanli; Ding, Junqiang; Chen, Ziqi; Luo, Jingyun; Mambakkam, Sowmya; Menon, Mitra; Snodgrass, Samantha; Veller, Carl; Wu, Shenshen; Wu, Siying; Zhuo, Lin; Xiao, Yingjie; Yang, Xiaohong; Stitzer, Michelle C.; Runcie, Daniel; Yan, Jianbing; Ross-Ibarra, Jeffrey
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; University of California System; University of California Davis; Jilin Academy of Agricultural Sciences; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; University of California System; University of California Davis; Purdue University System; Purdue University; Yunnan Academy of Agricultural Sciences; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Santa Barbara; Sichuan Agricultural University; Henan Agricultural University; Iowa State University; University of Chicago; China Agricultural University; Cornell University; Cornell University; University of California System; University of California Davis; Yazhouwan National Laboratory; University of California System; University of California Davis
  摘要：The origins of maize were the topic of vigorous debate for nearly a century, but neither the current genetic model nor earlier archaeological models account for the totality of available data, and recent work has highlighted the potential contribution of a wild relative, Zea mays ssp. mexicana. Our population genetic analysis reveals that the origin of modern maize can be traced to an admixture between ancient maize and Zea mays ssp. mexicana in the highlands of Mexico some 4000 years after do...
• Cheaper microscope may bring protein mapping to the masses AI翻译
  作者：Hand, Eric
• Blurring boundaries AI翻译
  作者：Sisley, Stephanie
  作者单位：Baylor College of Medicine
• Filming DNA repair at the atomic level AI翻译
  作者：Vos, Marten H.
  作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm)
• Mutation hotspots during meiosis AI翻译
  作者：Baudat, Frederic; de Massy, Bernard
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier
• AN ALKALINE SOLUTION AI翻译
  作者：Cornwall, Warren
• Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells AI翻译
  作者：Park, Simone L.; Christo, Susan N.; Wells, Alexandria C.; Gandolfo, Luke C.; Zaid, Ali; Alexandre, Yannick O.; Burn, Thomas N.; Schroeder, Jan; Collins, Nicholas; Han, Seong-Ji; Guillaume, Stephane M.; Evrard, Maximilien; Castellucci, Clara; Davies, Brooke; Osman, Maleika; Obers, Andreas; McDonald, Keely M.; Wang, Huimeng; Mueller, Scott N.; Kannourakis, George; Berzins, Stuart P.; Mielke, Lisa A.; Carbone, Francis R.; Kallies, Axel; Speed, Terence P.; Belkaid, Yasmine; Mackay, Laura K.
  作者单位：University of Melbourne; Peter Doherty Institute; National Institutes of Health (NIH) - USA; University of Melbourne; Walter & Eliza Hall Institute; Federation University Australia; La Trobe University; Olivia Newton-John Cancer Research Institute; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of Pennsylvania
  摘要：Skin-resident CD8(+) T cells include distinct interferon-gamma-producing [tissue-resident memory T type 1 (T(RM)1)] and interleukin-17 (IL-17)-producing (T(RM)17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that T(RM)1 and T(RM)17 cells navigate divergent trajectories to acquire tissue residency in the skin. T(RM)1 cells depend on a T-bet-Hobit-IL-15 axis, wh...