作者：Agathokleous, Evgenios; Feng, Zhaozhong; Sicard, Pierre
作者单位：Nanjing University of Information Science & Technology
作者：Engblom, Camilla; Thrane, Kim; Lin, Qirong; Andersson, Alma; Toosi, Hosein; Chen, Xinsong; Steiner, Embla; Lu, Chang; Mantovani, Giulia; Hagemann-Jensen, Michael; Saarenpaa, Sami; Jangard, Mattias; Saez-Rodriguez, Julio; Michaelsson, Jakob; Hartman, Johan; Lagergren, Jens; Mold, Jeff E.; Lundeberg, Joakim; Frisen, Jonas
作者单位：Karolinska Institutet; Royal Institute of Technology; SciLifeLab; SciLifeLab; Royal Institute of Technology; Karolinska Institutet; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Sophiahemmet University; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital
摘要：The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial transcriptomics of variable, diversity, and joining (VDJ) sequences (Spatial VDJ), a method that maps B cell and T cell receptor sequences in human tissue sections. Spatial VDJ captures lymphocyte clones that match canonical B and T cell distributions and amplifies clonal sequences confirmed by orthogonal methods. We found spatial congruency between...
作者：Li, Biao; Kou, Gang; Li, Hemin; Guo, Kun; Shi, Yong
作者单位：Southwestern University of Finance & Economics - China; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences
作者：Chien, Colleen V.; Ouellette, Lisa Larrimore
作者单位：University of California System; University of California Berkeley; Stanford University
