作者：Irannezhad, Masoud; Sadeqi, Amin; Liu, Junguo; Chen, Deliang
作者单位：University of Oulu; University of Turku; North China University of Water Resources & Electric Power; University of Gothenburg
作者：Ma, Demin; Hu, Meiqin; Yang, Xiaotong; Liu, Qiang; Ye, Fan; Cai, Weijie; Wang, Yong; Xu, Ximing; Chang, Shenghai; Wang, Ruiying; Yang, Wei; Ye, Sheng; Su, Nannan; Fan, Minrui; Xu, Haoxing; Guo, Jiangtao
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University; Ocean University of China; Zhejiang University; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Zhejiang University; Tianjin University; Zhejiang University; University of Michigan System; University of Michigan; Zhejiang University; Zhejiang University; Zhejiang University
摘要：Insects rely on a family of seven transmembrane proteins called gustatory receptors (GRs) to encode different taste modalities, such as sweet and bitter. We report structures of Drosophila sweet taste receptors GR43a and GR64a in the apo and sugar-bound states. Both GRs form tetrameric sugar-gated cation channels composed of one central pore domain (PD) and four peripheral ligand-binding domains (LBDs). Whereas GR43a is specifically activated by the monosaccharide fructose that binds to a narr...
