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作者：Zhou, Yuxin; McManus, Jerry F.
作者单位：Columbia University; Columbia University; University of California System; University of California Santa Barbara
摘要：During Heinrich events, great armadas of icebergs episodically flooded the North Atlantic Ocean and weakened overturning circulation. The ice discharges of these episodes constrain the sensitivity of overturning circulation to iceberg melting. We reconstructed these ice discharges to be as high as 0.13 sverdrup (Sv) (1 Sv = 1 million cubic meters per second) during Heinrich event 4 and to average 0.029 Sv over all episodes. The present-day Greenland Ice Sheet calving of icebergs is comparable ...
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作者：Brainard, Jeffrey
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作者：Service, Robert F.
摘要：Practical uses for quantum computers are emerging in chemistry, promising to speed the development of materials, catalysts, and drugs
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作者：Cummings, Sean
摘要：Pathogen that kills victims within days leaps from Caribbean to Red Sea
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作者：de Oliveira, Gabriel; Lehrter, John; Powers, Sean; Mataveli, Guilherme; Santos, Celso
作者单位：University of South Alabama; Dauphin Island Sea Lab; Instituto Nacional de Pesquisas Espaciais (INPE); University of East Anglia; Universidade Federal da Paraiba
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作者：Leslie, Mitch
摘要：Five drugs are now approved or in trials for genetic condition that triggers misplaced bone growth
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作者：Ai, Shenghao; Liu, Zongyang; Ai, Xiaoyan; Pan, Yi; Ai, Yingwei
作者单位：Chinese Academy of Sciences; Sichuan University
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作者：Allen, Jennifer; Watts, Duncan J.; Rand, David G.
作者单位：Massachusetts Institute of Technology (MIT); University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Low uptake of the COVID-19 vaccine in the US has been widely attributed to social media misinformation. To evaluate this claim, we introduce a framework combining lab experiments (total N = 18,725), crowdsourcing, and machine learning to estimate the causal effect of 13,206 vaccine-related URLs on the vaccination intentions of US Facebook users (N approximate to 233 million). We estimate that the impact of unflagged content that nonetheless encouraged vaccine skepticism was 46-fold greater tha...
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作者：Thorp, H. Holden
摘要：Last week, Science, Science Advances, and Science Translational Medicine published an extensive set of papers from the PsychENCODE Consortium, a multi-institutional collaboration whose aim is to study the genetics of neuropsychiatric disorders such as bipolar disorder, autism spectrum disorder, and schizophrenia. The papers, collectively called PsychENCODE2, apply advances in single-cell and multi-omic technologies to postmortem brain tissue to elucidate factors that may help explain and devel...
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作者：Princen, Katrien; Van Dooren, Tom; van Gorsel, Marit; Louros, Nikolaos; Yang, Xiaojuan; Dumbacher, Michael; Bastiaens, Ilse; Coupet, Kristel; Dupont, Shana; Cuveliers, Eva; Lauwers, Annick; Laghmouchi, Mohamed; Vanwelden, Thomas; Carmans, Sofie; Van Damme, Nele; Duhamel, Hein; Vansteenkiste, Seppe; Prerad, Jovan; Pipeleers, Karolien; Rodiers, Olivier; De Ridder, Liese; Claes, Sofie; Busschots, Yoni; Pringels, Lentel; Verhelst, Vanessa; Debroux, Eveline; Brouwer, Marinka; Lievens, Sam; Tavernier, Jan; Farinelli, Melissa; Hughes-Asceri, Sandrine; Voets, Marieke; Winderickx, Joris; Wera, Stefaan; de Wit, Joris; Schymkowitz, Joost; Rousseau, Frederic; Zetterberg, Henrik; Cummings, Jeffrey L.; Annaert, Wim; Cornelissen, Tom; De Winter, Hans; De Witte, Koen; Fivaz, Marc; Griffioen, Gerard
作者单位：Flanders Institute for Biotechnology (VIB); KU Leuven; Flanders Institute for Biotechnology (VIB); Flanders Institute for Biotechnology (VIB); KU Leuven; Flanders Institute for Biotechnology (VIB); Ghent University; KU Leuven; University of Gothenburg; Sahlgrenska University Hospital; University of London; University College London; University of London; University College London; University of Wisconsin System; University of Wisconsin Madison; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Antwerp
摘要：Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification of a class of compounds called ReS19-T, which are able to restore calcium homeostasis in cell-based models of tau pathology. Aberrant tau accumulation leads to uncontrolled activation of store-operated calcium channels (SOCCs) by remodeling septin filaments at the cell cortex. Binding of ReS19-T to septins restores filament assembly in the disease state and restrains...
