6700期

最新文章

• A tiny, long-distance hunter AI翻译
  作者：Gordillo, Leonardo; Cerda, Enrique
  作者单位：Universidad de Santiago de Chile
  摘要：Lacrymaria olor cytoskeleton and membrane origami enables rapid cell hyperextension
• Missed connections AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
  摘要：A sociologist confronts the future of care work in an age of automation
• Pioneering pig liver transplant AI翻译
  作者：[Anonymous]
• Axis formation in annual killifish: Nodal and β-catenin regulate morphogenesis without Huluwa prepatterning AI翻译
  作者：Abitua, Philip B.; Stump, Laura M.; Aksel, Deniz C.; Schier, Alexander F.
  作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; University of Basel; University of Washington; University of Washington Seattle
  摘要：Axis formation in fish and amphibians typically begins with a prepattern of maternal gene products. Annual killifish embryogenesis, however, challenges prepatterning models as blastomeres disperse and then aggregate to form the germ layers and body axes. We show that huluwa, a prepatterning factor thought to break symmetry by stabilizing beta-catenin, is truncated and inactive in Nothobranchius furzeri. Nuclear beta-catenin is not selectively stabilized on one side of the blastula but accumula...
• Molecular mechanism of substrate recognition and cleavage by human γ-secretase AI翻译
  作者：Guo, Xuefei; Li, Haotian; Yan, Chuangye; Lei, Jianlin; Zhou, Rui; Shi, Yigong
  作者单位：Tsinghua University; Westlake Laboratory; Westlake University; Westlake University; Westlake University
  摘要：Successive cleavages of amyloid precursor protein C-terminal fragment with 99 residues (APP-C99) by gamma-secretase result in amyloid-beta (A beta) peptides of varying lengths. Most cleavages have a step size of three residues. To elucidate the underlying mechanism, we determined the atomic structures of human gamma-secretase bound individually to APP-C99, A beta 49, A beta 46, and A beta 43. In all cases, the substrate displays the same structural features: a transmembrane alpha-helix, a thre...
• 'Google for DNA' indexes 10% of world's known sequence data AI翻译
  作者：Offord, Catherine
  摘要：Achievement demonstrates feasibility of making all of life's code easily searchable, researchers say
• Cellular architecture shapes the naïve T cell response AI翻译
  作者：Hale, Benjamin D.; Severin, Yannik; Graebnitz, Fabienne; Stark, Dominique; Guignard, Daniel; Mena, Julien; Festl, Yasmin; Lee, Sohyon; Hanimann, Jacob; Zangger, Nathan S.; Meier, Michelle; Goslings, David; Lamprecht, Olga; Frey, Beat M.; Oxenius, Annette; Snijder, Berend
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics
  摘要：After antigen stimulation, na & iuml;ve T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic predeterminants controlling these single-cell decisions remain enigmatic. We found that the subcellular architectures of na & iuml;ve CD8 T cells, defined by the presence (T-& Oslash;) or absence (T-O) of nuclear envelope invaginations, changed with maturation, activation, and differentiation...
• Cellular architecture shapes the naive T cell response AI翻译
  作者：Hale, Benjamin D.; Severin, Yannik; Graebnitz, Fabienne; Stark, Dominique; Guignard, Daniel; Mena, Julien; Festl, Yasmin; Lee, Sohyon; Hanimann, Jacob; Zangger, Nathan S.; Meier, Michelle; Goslings, David; Lamprecht, Olga; Frey, Beat M.; Oxenius, Annette; Snijder, Berend
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics
  摘要：After antigen stimulation, naive T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic predeterminants controlling these single-cell decisions remain enigmatic. We found that the subcellular architectures of naive CD8 T cells, defined by the presence (T-& Oslash;) or absence (T-O) of nuclear envelope invaginations, changed with maturation, activation, and differentiation. Upon T cell ...
• Peter Higgs (1929-2024) AI翻译
  作者：Quigg, Chris
  作者单位：United States Department of Energy (DOE); University of Chicago; Fermi National Accelerator Laboratory
  摘要：Physicist who lent his name to the Higgs boson
• Fraud mars teen science fair entry AI翻译
  作者：[Anonymous]