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作者：Deng, Tingting; Gao, Zhiqiang; Li, Ze; Qiu, Pengfei; Li, Zhi; Yuan, Xinjie; Ming, Chen; Wei, Tian-Ran; Chen, Lidong; Shi, Xun
作者单位：Chinese Academy of Sciences; Shanghai Institute of Ceramics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The recently discovered metal-like room-temperature plasticity in inorganic semiconductors reshapes our knowledge of the physical properties of materials, giving birth to a series of new-concept functional materials. However, current room-temperature plastic inorganic semiconductors are still very rare, and their performance is inferior to that of classic brittle semiconductors. Taking classic bismuth telluride (Bi2Te3)-based thermoelectric semiconductors as an example, we show that antisite d...
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作者：Langin, Katie
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作者：Kaiser, Jocelyn
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作者：Couzin-Frankel, Jennifer; Jacobs, Phie
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作者：Gajbhiye, Deodatta S.; Fernandes, Genevieve L.; Oz, Itay; Nahmias, Yuni; Golan, Matan
作者单位：VOLCANI INSTITUTE OF AGRICULTURAL RESEARCH; Hebrew University of Jerusalem
摘要：Hatching is a critical event in the life history of oviparous species. The decision to hatch is often carefully timed to coincide with favorable conditions that will improve survival through early life stages. However, how the relevant cues are relayed to trigger hatching remains unknown. In this work, we show that thyrotropin-releasing hormone (Trh) is the neuroendocrine activator of hatching in zebrafish. To elicit hatching, Trh neurons form a transient circuit that deposits the peptide into...
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作者：Martin, Paul; Pardo-Pastor, Carlos; Jenkins, R. Gisli; Rosenblatt, Jody
作者单位：University of Bristol; Pompeu Fabra University; Imperial College London; University of London; King's College London; Francis Crick Institute
摘要：Although the age of the genome gave us much insight about how our organs fail with disease, it also suggested that diseases do not arise from mutations alone; rather, they develop as we age. In this Review, we examine how wound healing might act to ignite disease. Wound healing works well when we are younger, repairing damage from accidents, environmental assaults, and battles with pathogens. Yet, with age and accumulation of mutations and tissue damage, the repair process can devolve, leading...
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作者：Reddy, Nishith R.; Maachi, Hasna; Xiao, Yini; Simic, Milos S.; Yu, Wei; Tonai, Yurie; Cabanillas, Daniela A.; Serrano-Wu, Ella; Pauerstein, Philip T.; Tamaki, Whitney; Allen, Greg M.; Parent, Audrey V.; Hebrok, Matthias; Lim, Wendell A.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; Technical University of Munich; Technical University of Munich; German Center for Diabetes Research (DZD)
摘要：Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4+ T cells with synthetic Notch (synNotch) receptors driving antigen-triggered production of anti-inflammatory payloads. Screening a diverse library of suppression programs, we observed the strongest suppression of cytotoxic T cell attack by the production of both anti-inflammatory factors (interleukin-10, transforming g...
