2024

最新文章

• Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells AI翻译
  作者：Pessoa Rodrigues, Cecilia; Collins, Joseph M.; Yang, Song; Martinez, Catherine; Kim, Ji Wook; Lama, Chhiring; Nam, Anna S.; Alt, Clemens; Lin, Charles; Zon, Leonard I.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Cornell University; Weill Cornell Medicine; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface Calreticulin (Calr), an eat-me signal induced by reactive oxygen species (ROS). Using zebrafish genetics, we identified Beta-2-microglobulin (B2m) as a crucial don't eat-me signal on blood stem cells. A chemical screen revealed inducers of surface Calr that promoted HSC proliferation without triggering ROS or macrophage clearance. Whole-genome CRISPR-Cas9 screening showed that Toll-like receptor 3 (Tlr3) signa...
• Where and with whom does a brief social-belonging intervention promote progress in college? (vol 380, pg 499, 2023) AI翻译
  作者：Walton, G. M.
• The power of sitting still AI翻译
  作者：Bartolotta, Sabrina
  作者单位：Catholic University of the Sacred Heart
• Ship to probe Arctic ecosystems AI翻译
  作者：Brainard, Jeffrey
• Palladium-catalyzed cross-coupling of alcohols with olefins by positional tuning of a counteranion AI翻译
  作者：Kaster, Sven H. M.; Zhu, Lei; Lyon, William L.; Ma, Rulin; Ammann, Stephen E.; White, M. Christina
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Transition metal-catalyzed cross-couplings have great potential to furnish complex ethers; however, challenges in the C(sp(3))-O functionalization step have precluded general methods. Here, we describe computationally guided transition metal-ligand design that positions a hydrogen-bond acceptor anion at the reactive site to promote functionalization. A general cross-coupling of primary, secondary, and tertiary aliphatic alcohols with terminal olefins to furnish >130 ethers is achieved. The mil...
• NIH sued over name-change data AI翻译
  作者：Richter, Hannah
• Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers AI翻译
  作者：Sundaram, Laksshman; Kumar, Arvind; Zatzman, Matthew; Salcedo, Adriana; Ravindra, Neal; Shams, Shadi; Louie, Brian H.; Bagdatli, S. Tansu; Myers, Matthew A.; Sarmashghi, Shahab; Choi, Hyo Young; Choi, Won-Young; Yost, Kathryn E.; Zhao, Yanding; Granja, Jeffrey M.; Hinoue, Toshinori; Hayes, D. Neil; Cherniack, Andrew; Felau, Ina; Choudhry, Hani; Zenklusen, Jean C.; Farh, Kyle Kai-How; McPherson, Andrew; Curtis, Christina; Laird, Peter W.; Corces, M. Ryan; Chang, Howard Y.; Greenleaf, William J.
  作者单位：Stanford University; Stanford University; Illumina; Nvidia Corporation; Memorial Sloan Kettering Cancer Center; Stanford University; Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Tennessee System; University of Tennessee Health Science Center; University of Tennessee System; University of Tennessee Health Science Center; University of Tennessee System; University of Tennessee Health Science Center; Van Andel Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); King Abdulaziz University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; Stanford University; Howard Hughes Medical Institute; Stanford University
• Climate change exacerbates the environmental impacts of agriculture AI翻译
  作者：Yang, Yi; Tilman, David; Jin, Zhenong; Smith, Pete; Barrett, Christopher B.; Zhu, Yong-Guan; Burney, Jennifer; D'Odorico, Paolo; Fantke, Peter; Fargione, Joe; Finlay, Jacques C.; Rulli, Maria Cristina; Sloat, Lindsey; van Groenigen, Kees Jan; West, Paul C.; Ziska, Lewis; Michalak, Anna M.; Lobell, David B.; Clark, Michael; Colquhoun, Jed; Garg, Teevrat; Garrett, Karen A.; Geels, Camilla; Hernandez, Rebecca R.; Herrero, Mario; Hutchison, William D.; Jain, Meha; Jungers, Jacob M.; Liu, Beibei; Mueller, Nathaniel D.; Ortiz-Bobea, Ariel; Schewe, Jacob; Song, Jie; Verheyen, Julie; Vitousek, Peter; Wada, Yoshihide; Xia, Longlong; Zhang, Xin; Zhuang, Minghao
  作者单位：Chongqing University; Chongqing University; Chongqing University; University of Minnesota System; University of Minnesota Twin Cities; University of California System; University of California Santa Barbara; University of Minnesota System; University of Minnesota Twin Cities; University of Aberdeen; Cornell University; Cornell University; Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; University of California System; University of California San Diego; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California Berkeley; Technical University of Denmark; Nature Conservancy; University of Minnesota System; University of Minnesota Twin Cities; Polytechnic University of Milan; University of Exeter; University of Minnesota System; University of Minnesota Twin Cities; Columbia University; Carnegie Institution for Science; Stanford University; Stanford University; Alphabet Inc.; Google Incorporated; Stanford University; University of Oxford; University of Oxford; University of Wisconsin System; University of Wisconsin Madison; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Aarhus University; University of California System; University of California Davis; Cornell University; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; University of Minnesota System; University of Minnesota Twin Cities; Nanjing University; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Cornell University; Potsdam Institut fur Klimafolgenforschung; Chongqing University; KU Leuven; King Abdullah University of Science & Technology; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; University System of Maryland; University of Maryland Center for Environmental Science; China Agricultural University
  摘要：Agriculture's global environmental impacts are widely expected to continue expanding, driven by population and economic growth and dietary changes. This Review highlights climate change as an additional amplifier of agriculture's environmental impacts, by reducing agricultural productivity, reducing the efficacy of agrochemicals, increasing soil erosion, accelerating the growth and expanding the range of crop diseases and pests, and increasing land clearing. We identify multiple pathways throu...
• Roots in Brazil's Amazon mangroves AI翻译
  作者：Silva-Junior, Celso H. L.
  作者单位：Universidade Federal do Maranhao
• In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells AI翻译
  作者：Dietrich, Lea; Agip, Ahmed-Noor A.; Kunz, Christina; Schwarz, Andre; Kuehlbrandt, Werner
  作者单位：Max Planck Society; Max Planck Society
  摘要：Cells depend on a continuous supply of adenosine triphosphate (ATP), the universal energy currency. In mitochondria, ATP is produced by a series of redox reactions, whereby an electrochemical gradient is established across the inner mitochondrial membrane. The ATP synthase harnesses the energy of the gradient to generate ATP from adenosine diphosphate (ADP) and inorganic phosphate. We determined the structure of ATP synthase within mitochondria of the unicellular flagellate Polytomella by elec...