2024

最新文章

• Mental programming of spatial sequences in working memory in the macaque frontal cortex AI翻译
  作者：Tian, Zhenghe; Chen, Jingwen; Zhang, Cong; Min, Bin; Xu, Bo; Wang, Liping
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Lingang Laboratory
• The revolution in high-throughput proteomics and AI AI翻译
  作者：Topol, Eric J.
• Four decades of Hawaiian monk seal entanglement data reveal the benefits of plastic debris removal AI翻译
  作者：Baker, Jason D.; Johanos, Thea C.; Ronco, Hope; Becker, Brenda L.; Morioka, James; O'Brien, Kevin; Donohue, Mary J.
  作者单位：National Oceanic Atmospheric Admin (NOAA) - USA; University of Hawaii System
  摘要：Abandoned, lost, or otherwise discarded fishing gear causes harm to marine species and ecosystems. To mitigate the destruction wrought by this ocean plastic debris, various cleanup programs have been established, though to our knowledge the benefits of such efforts to marine species and ecosystems have not yet been empirically demonstrated. We examined more than 40 years of Hawaiian monk seal marine debris entanglement records before and after large-scale marine debris removal efforts were ini...
• Lithium extraction from brine through a decoupled and membrane-free electrochemical cell design AI翻译
  作者：Li, Zhen; Chen, I-Chun; Cao, Li; Liu, Xiaowei; Huang, Kuo-Wei; Lai, Zhiping
  作者单位：King Abdullah University of Science & Technology
  摘要：The sustainability of lithium-based energy storage or conversion systems, e.g., lithium-ion batteries, can be enhanced by establishing methods of efficient lithium extraction from harsh brines. In this work, we describe a decoupled membrane-free electrochemical cell that cycles lithium ions between iron-phosphate electrodes and features cathode (brine) and anode (fresh water) compartments that are isolated from each other yet electrochemically connected through a pair of silver/silver-halide r...
• Pact on nuclear-plant wastewater AI翻译
  作者：Brainard, Jeffrey
• A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria AI翻译
  作者：Chahine, Z.; Abel, S.; Hollin, T.; Barnes, G. L.; Chung, J. H.; Daub, M. E.; Renard, I.; Choi, J. Y.; Vydyam, P.; Pal, A.; Alba-Argomaniz, M.; Banks, C. A. S.; Kirkwood, J.; Saraf, A.; Camino, I.; Castaneda, P.; Cuevas, M. C.; De Mercado-Arnanz, J.; Fernandez-Alvaro, E.; Garcia-Perez, A.; Ibarz, N.; Viera-Morilla, S.; Prudhomme, J.; Joyner, C. J.; Bei, A. K.; Florens, L.; Ben Mamoun, C.; Vanderwal, C. D.; Le Roch, K. G.
  作者单位：University of California System; University of California Riverside; University of California System; University of California Irvine; Yale University; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Stowers Institute for Medical Research; University of California System; University of California Riverside; GlaxoSmithKline; Yale University; University of California System; University of California Irvine
  摘要：We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene natural products that is effective against drug-sensitive and drug-resistant Plasmodium falciparum strains, blocking both asexual replication and sexual differentiation. In vivo studies using a humanized mouse model of malaria confirm strong efficacy of the compound in animals with no apparent hemolytic activity or toxicity. Complementary chemical, molecular, and genomics analyses revealed that MED6-189 t...
• RESEARCH ETHICS Canada's Indigenous groups get apology AI翻译
  作者：Brainard, Jeffrey
• Genetic excision of the regulatory cardiac troponin I extension in high-heart rate mammal clades AI翻译
  作者：Joyce, William; He, Kai; Zhang, Mengdie; Ogunsola, Samuel; Wu, Xini; Joseph, Kelvin T.; Bogomolny, David; Yu, Wenhua; Springer, Mark S.; Xie, Jiuyong; Signore, Anthony V.; Campbell, Kevin L.
  作者单位：Aarhus University; University of Manchester; Guangzhou University; University of Manitoba; University of Manitoba; University of California System; University of California Riverside; Centro Nacional de Investigaciones Cardiovasculares (CNIC)
  摘要：Mammalian cardiac troponin I (cTnI) contains a highly conserved amino-terminal extension harboring protein kinase A targets [serine-23 and -24 (Ser(23/24))] that are phosphorylated during beta-adrenergic stimulation to defend diastolic filling by means of an increased cardiomyocyte relaxation rate. In this work, we show that the Ser(23/24)-encoding exon 3 of TNNI3 was pseudoexonized multiple times in shrews and moles to mimic Ser(23/24) phosphorylation without adrenergic stimulation, facilitat...
• Electrically driven proton transfer promotes Bronsted acid catalysis by orders of magnitude (vol 383, pg 757, 2024) AI翻译
  作者：Westendorff, K. S.
• Virtual You: How Building Your Digital Twin Will Revolutionize Medicine and Change Your Life AI翻译
  作者：[Anonymous]