2024

最新文章

• Trust edges up-slightly AI翻译
  作者：Thorp, H. Holden
• EPA braces for change under Trump AI翻译
  作者：Stokstad, Erik
• Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation AI翻译
  作者：Yilmaz, Feyza; Karageorgiou, Charikleia; Kim, Kwondo; Pajic, Petar; Scheer, Kendra; Beck, Christine R.; Torregrossa, Ann-Marie; Lee, Charles; Gokcumen, Omer
  作者单位：Jackson Laboratory; State University of New York (SUNY) System; University at Buffalo, SUNY; University of Connecticut; University of Connecticut; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY
  摘要：Previous studies suggested that the copy number of the human salivary amylase gene, AMY1, correlates with starch-rich diets. However, evolutionary analyses are hampered by the absence of accurate, sequence-resolved haplotype variation maps. We identified 30 structurally distinct haplotypes at nucleotide resolution among 98 present-day humans, revealing that the coding sequences of AMY1 copies are evolving under negative selection. Genomic analyses of these haplotypes in archaic hominins and an...
• Fossil worm pushes back origin of most animals AI翻译
  作者：Brainard, Jeffrey
• Direct hearing measurements in a baleen whale suggest ultrasonic sensitivity AI翻译
  作者：Houser, Dorian S.; Kvadsheim, Petter H.; Kleivane, Lars; Mulsow, Jason; Olberg, Rolf A.; Harms, Craig A.; Teilmann, Jonas; Finneran, James J.
  作者单位：Norwegian Defence Research Establishment; North Carolina State University; Aarhus University; United States Department of Defense; United States Navy; Naval Information Warfare Center Pacific
  摘要：Predicting and mitigating the impacts of anthropogenic ocean noise on marine animals is hindered by a lack of information on hearing in these species. We established a catch-and-release program to temporarily hold adolescent minke whales (Balaenoptera acutorostrata) for hearing tests during their summer migration. In 2023, two minke whales provided measures of the auditory brainstem response and data on the frequency range of their hearing. Results show that minke whales are sensitive to sound...
• Culture in humans and other animals AI翻译
  作者：Richerson, Peter J.; Boyd, Robert T.
  作者单位：University of California System; University of California Davis; Arizona State University; Arizona State University-Tempe
• Connection, not perfection AI翻译
  作者：Suresh, Ahalya
  作者单位：Deakin University
• Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes AI翻译
  作者：Zhu, Xiaoqiang; Cruz, Victor Emmanuel; Zhang, He; Erzberger, Jan P.; Mendell, Joshua T.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation. We applied selective ribosome profiling to further investigate the determinants of CCR4-NOT recruitment to ribosomes in mammalian cells. This revealed that specific arginine codons in the P-site are strong signals for ribosomal recruitment of human CNOT3, a CCR4-NOT subunit. Cryo-electron microsc...
• Fossil worm pushes back origin of most animals AI翻译
  作者：Brainard, Jeffrey
• Preserve Petra and Bedouin rights in Jordan AI翻译
  作者：Hussein, Hussam; Mason, Olivia
  作者单位：University of Oxford; Newcastle University - UK