6743期

最新文章

• Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues AI翻译
  作者：Walker, Emily M.; Pearson, Gemma L.; Lawlor, Nathan; Stendahl, Ava M.; Lietzke, Anne; Sidarala, Vaibhav; Zhu, Jie; Stromer, Tracy; Reck, Emma C.; Li, Jin; Levi-D'Ancona, Elena; Pasmooij, Mabelle B.; Hubers, Dre L.; Renberg, Aaron; Mohamed, Kawthar; Parekh, Vishal S.; Zhang, Irina X.; Thompson, Benjamin; Zhang, Deqiang; Ware, Sarah A.; Haataja, Leena; Qi, Nathan; Parker, Stephen C. J.; Arvan, Peter; Yin, Lei; Kaufman, Brett A.; Satin, Leslie S.; Sussel, Lori; Stitzel, Michael L.; Soleimanpour, Scott A.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Jackson Laboratory; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Michigan System; University of Michigan; University of Colorado System; University of Colorado Anschutz Medical Campus; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Ann Arbor Healthcare System
  摘要：Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. In this work, we report that dysfunctional mitochondrial quality control engages a retrograde (mitonuclear) signaling program that impairs cellular identity and maturity in beta cells, hepatocytes, and brown adipocytes. Targeted deficiency throughout the mitochondrial quality control pathway, including genome integrity, dynamics,...
• Structural pathway for PI3-kinase regulation by VPS15 in autophagy AI翻译
  作者：Cook, Annan S. I.; Chen, Minghao; Nguyen, Thanh N.; Cabezudo, Ainara Claveras; Khuu, Grace; Rao, Shanlin; Garcia, Samantha N.; Yang, Mingxuan; Iavarone, Anthony T.; Ren, Xuefeng; Lazarou, Michael; Hummer, Gerhard; Hurley, James H.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Walter & Eliza Hall Institute; University of Melbourne; Monash University; Max Planck Society; Max Planck Society; Goethe University Frankfurt; University of California System; University of California Berkeley
  摘要：The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and PI3KC3-C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzyme activation through cryo-electron microscopy analysis of PI3KC3-C1. The inactive conformation of the VPS15 pseudokinase stabilizes the inactive conformation, sequestering its N-myristate in the N-lobe of the pseudokinase. Upon activation, the myristate is liberated such that the VPS34 lipi...
• A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals AI翻译
  作者：Jobin, Katarzyna; Seetharama, Deeksha; Ruettger, Lennart; Fenton, Chloe; Kharybina, Ekaterina; Wirsching, Annerose; Huang, Anfei; Knoepper, Konrad; Kaisho, Tsuneyasu; Busch, Dirk H.; Vaeth, Martin; Saliba, Antoine-Emmanuel; Graw, Frederik; Pulfer, Alain; Gonzalez, Santiago F.; Zehn, Dietmar; Liang, Yinming; Ugur, Milas; Gasteiger, Georg; Kastenmueller, Wolfgang
  作者单位：Max Planck Society; University of Wurzburg; Wakayama Medical University; Technical University of Munich; Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Universita della Svizzera Italiana; Technical University of Munich; Henan Medical University
  摘要：T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed their migration has been unclear. We identified a distinct priming phase that favors CD8 T cells expressing receptors with high affinity for antigen. CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs i...
• Wildfires jeopardize drinking water safety AI翻译
  作者：Li, Xuan; Fu, Qizi; Wang, Qilin
  作者单位：University of Technology Sydney
• Mapping a chunk of mouse brain AI翻译
  作者：Servick, Kelly
• How does cancer affect motivation? AI翻译
  作者：Dalley, Jeffrey W.; Lynall, Mary-Ellen
  作者单位：University of Cambridge; University of Cambridge
• Modernizing wildfire management in China AI翻译
  作者：Li, Junran
  作者单位：University of Hong Kong
• A phage tail-like bacteriocin suppresses competitors in metapopulations of pathogenic bacteria (vol 384, eado0713, 2024) AI翻译
  作者：Backman, T.
• An awakening AI翻译
  作者：Martignoni, Maria
  作者单位：University System of Georgia; Georgia Institute of Technology
• The genetic architecture of and evolutionary constraints on the human pelvic form AI翻译
  作者：Xu, Liaoyi; Kun, Eucharist; Pandey, Devansh; Wang, Joyce Y.; Brasil, Marianne F.; Singh, Tarjinder; Narasimhan, Vagheesh M.
  作者单位：University of Texas System; University of Texas Austin; Western Washington University; Columbia University; NewYork-Presbyterian Hospital; Columbia University; University of Texas System; University of Texas Austin
  摘要：Human pelvic evolution following the human-chimpanzee divergence is thought to result in an obstetrical dilemma, a mismatch between large infant brains and narrowed female birth canals, but empirical evidence has been equivocal. By using deep learning on 31,115 dual-energy x-ray absorptiometry scans from UK Biobank, we identified 180 loci associated with seven highly heritable pelvic phenotypes. Birth canal phenotypes showed sex-specific genetic architecture, aligning with reproductive functio...