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作者：Iacopi, Francesca; Ferrari, Andrea C.
作者单位：University of Technology Sydney; University of Technology Sydney; University of Cambridge
摘要：The integration of non-silicon semiconductors into systems on chips is needed for advanced power and sensing technologies. A semiconducting graphene 'buffer' layer grown on silicon carbide is a step on this path.
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作者：Klemmer, Konstantin; Rolf, Esther
作者单位：Microsoft; Harvard University; Harvard University
摘要：Machine learning and satellite imagery have been used to map industrial infrastructure at sea - from fishing vessels to wind turbines. The findings provide a more comprehensive picture of maritime activity than ever before.
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作者：Li, Erwei; Wang, Luhong; Wang, Daqing; Chi, Jingyi; Lin, Zeran; Smith, Gordon I.; Klein, Samuel; Cohen, Paul; Rosen, Evan D.
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Rockefeller University; Washington University (WUSTL); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Oxytocin (OXT), a nine-amino-acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation and social behaviour1, and has become an intriguing therapeutic target for conditions such as autism and schizophrenia2. Exogenous OXT has also been shown to have effects on body weight, lipid levels and glucose homeostasis1,3, suggesting that it may also have therapeutic potential for metabolic disease1,4. It is unclear, however, whet...
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作者：Castelvecchi, Davide
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作者：Tollefson, Jeff
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作者：Zhao, Jian; Ji, Peixuan; Li, Yaqi; Li, Rui; Zhang, Kaimin; Tian, Hao; Yu, Kaicheng; Bian, Boyue; Hao, Luzhen; Xiao, Xue; Griffin, Will; Dudeck, Noel; Moro, Ramiro; Ma, Lei; de Heer, Walt A.
作者单位：Tianjin University; University System of Georgia; Georgia Institute of Technology
摘要：Semiconducting graphene plays an important part in graphene nanoelectronics because of the lack of an intrinsic bandgap in graphene1. In the past two decades, attempts to modify the bandgap either by quantum confinement or by chemical functionalization failed to produce viable semiconducting graphene. Here we demonstrate that semiconducting epigraphene (SEG) on single-crystal silicon carbide substrates has a band gap of 0.6 eV and room temperature mobilities exceeding 5,000 cm2 V-1 s-1, which ...
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作者：Loevestam, Sofia; Li, David; Wagstaff, Jane L.; Kotecha, Abhay; Kimanius, Dari; McLaughlin, Stephen H.; Murzin, Alexey G.; Freund, Stefan M. V.; Goedert, Michel; Scheres, Sjors H. W.
作者单位：MRC Laboratory Molecular Biology; Thermo Fisher Scientific
摘要：Intermediate species in the assembly of amyloid filaments are believed to play a central role in neurodegenerative diseases and may constitute important targets for therapeutic intervention1,2. However, structural information about intermediate species has been scarce and the molecular mechanisms by which amyloids assemble remain largely unknown. Here we use time-resolved cryogenic electron microscopy to study the in vitro assembly of recombinant truncated tau (amino acid residues 297-391) int...
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作者：LaMarche, Nelson M.; Hegde, Samarth; Park, Matthew D.; Maier, Barbara B.; Troncoso, Leanna; Le Berichel, Jessica; Hamon, Pauline; Belabed, Meriem; Mattiuz, Raphael; Hennequin, Clotilde; Chin, Theodore; Reid, Amanda M.; Reyes-Torres, Ivan; Nemeth, Erika; Zhang, Ruiyuan; Olson, Oakley C.; Doroshow, Deborah B.; Rohs, Nicholas C.; Gomez, Jorge E.; Veluswamy, Rajwanth; Hall, Nicole; Venturini, Nicholas; Ginhoux, Florent; Liu, Zhaoyuan; Buckup, Mark; Figueiredo, Igor; Roudko, Vladimir; Miyake, Kensuke; Karasuyama, Hajime; Gonzalez-Kozlova, Edgar; Gnjatic, Sacha; Passegue, Emmanuelle; Kim-Schulze, Seunghee; Brown, Brian D.; Hirsch, Fred R.; Kim, Brian S.; Marron, Thomas U.; Merad, Miriam
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Universite Paris Saclay; Chinese Academy of Sciences; Shanghai Jiao Tong University; Icahn School of Medicine at Mount Sinai; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
摘要：Myeloid cells are known to suppress antitumour immunity(1). However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA sequencing of human and mouse non-small cell lung cancer (NSCLC) lesions, and found that in both species the type 2 cytokine interleukin-4 (IL-4) was predicted to be the primary driver of the tumour-infiltrating monocyte-derived macrophage phenotype. Using a panel of conditional knockout mice, we found that only d...
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作者：Alesina, Alberto; Hohmann, Sebastian; Michalopoulos, Stelios; Papaioannou, Elias
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作者：Maus, Victor; Werner, Tim T.
作者单位：Vienna University of Economics & Business; International Institute for Applied Systems Analysis (IIASA); University of Melbourne
摘要：As the race to extract minerals and metals for clean-energy technologies accelerates, researchers must take more steps to map and study mines globally.
