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作者：Ho, Kin On; Yang, Sen
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Hong Kong University of Science & Technology
摘要：By adapting a device designed to create extremely high pressures into one that can sense magnetic fields, researchers have obtained evidence that a hydrogen-rich material is a superconductor, eliminating long-standing doubts.
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作者：Elemans, Coen P. H.; Jiang, Weili; Jensen, Mikkel H.; Pichler, Helena; Mussman, Bo R.; Nattestad, Jacob; Wahlberg, Magnus; Zheng, Xudong; Xue, Qian; Fitch, W. Tecumseh
作者单位：University of Southern Denmark; Rochester Institute of Technology; University of Vienna; University of Southern Denmark; Odense University Hospital; University of Southern Denmark; University of Vienna
摘要：Baleen whales (mysticetes) use vocalizations to mediate their complex social and reproductive behaviours in vast, opaque marine environments(1). Adapting to an obligate aquatic lifestyle demanded fundamental physiological changes to efficiently produce sound, including laryngeal specializations(2-4). Whereas toothed whales (odontocetes) evolved a nasal vocal organ(5), mysticetes have been thought to use the larynx for sound production(1,6-8). However, there has been no direct demonstration tha...
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作者：Hsia, Oliver; Hinterndorfer, Matthias; Cowan, Angus D.; Iso, Kentaro; Ishida, Tasuku; Sundaramoorthy, Ramasubramanian; Nakasone, Mark A.; Imrichova, Hana; Schaetz, Caroline; Rukavina, Andrea; Husnjak, Koraljka; Wegner, Martin; Correa-Saez, Alejandro; Craigon, Conner; Casement, Ryan; Maniaci, Chiara; Testa, Andrea; Kaulich, Manuel; Dikic, Ivan; Winter, Georg E.; Ciulli, Alessio
作者单位：University of Dundee; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; Eisai Co Ltd; University of Dundee; Goethe University Frankfurt; University of Dundee
摘要：Targeted protein degradation is a pharmacological modality that is based on the induced proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and proteasomal degradation. This has been achieved either via proteolysis-targeting chimeras (PROTACs)-bifunctional compounds composed of two separate moieties that individually bind the target and E3 ligase, or via molecular glues that monovalently bind either the ligase or the target(1-4). Here, using orthogonal gen...
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作者：Libonati, Renata
作者单位：Universidade Federal do Rio de Janeiro
摘要：It's not just global warming that's driving the growth in destructive wildfires. Better land management is the first step to mitigating the risks.
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作者：Serini, Guido; Valdembri, Donatella; Zanivan, Sara; Morterra, Giulia; Burkhardt, Constanze; Caccavari, Francesca; Zammataro, Luca; Primo, Luca; Tamagnone, Luca; Logan, Malcolm; Tessier-Lavigne, Marc; Taniguchi, Masahiko; Pueschel, Andreas W.; Bussolino, Federico
作者单位：IRCCS Fondazione del Piemonte per l'Oncologia; University of Turin; University of Turin; University of Munster; IRCCS Fondazione del Piemonte per l'Oncologia; MRC National Institute for Medical Research; Stanford University; Howard Hughes Medical Institute; University of Tokyo
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作者：Larkin, James; Beland, Chloe; Ramalingam, Sivatharshini; Lyon, Alexander R.
作者单位：Royal Marsden NHS Foundation Trust; Royal Brompton Hospital
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作者：Collins, Pamela Y.; Sinha, Moitreyee; Concepcion, Tessa; Patton, George; Way, Thaisa; McCay, Layla; Mensa-Kwao, Augustina; Herrman, Helen; de Leeuw, Evelyne; Anand, Nalini; Atwoli, Lukoye; Bardikoff, Nicole; Booysen, Chantelle; Bustamante, Ines; Chen, Yajun; Davis, Kelly; Dua, Tarun; Foote, Nathaniel; Hughsam, Matthew; Juma, Damian; Khanal, Shisir; Kumar, Manasi; Lefkowitz, Bina; McDermott, Peter; Moitra, Modhurima; Ochieng, Yvonne; Omigbodun, Olayinka; Queen, Emily; Unuetzer, Juergen; Uribe-Restrepo, Jose Miguel; Wolpert, Miranda; Zeitz, Lian
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of Washington; University of Washington Seattle; University of Melbourne; Harvard University; Orygen, The National Centre of Excellence in Youth Mental Health; University of Melbourne; Universite de Montreal; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC); Aga Khan University; Universidad Peruana Cayetano Heredia; Sun Yat Sen University; World Health Organization; New York University; University of Nairobi; Duke University; University of Ibadan; Pontificia Universidad Javeriana
摘要：Urban life shapes the mental health of city dwellers, and although cities provide access to health, education and economic gain, urban environments are often detrimental to mental health(1,2). Increasing urbanization over the next three decades will be accompanied by a growing population of children and adolescents living in cities(3). Shaping the aspects of urban life that influence youth mental health could have an enormous impact on adolescent well-being and adult trajectories(4). We invite...
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作者：Ngo, Linh H.; Bert, Andrew G.; Dredge, B. Kate; Williams, Tobias; Murphy, Vincent; Li, Wanqiu; Hamilton, William B.; Carey, Kirstyn T.; Toubia, John; Pillman, Katherine A.; Liu, Dawei; Desogus, Jessica; Chao, Jeffrey A.; Deans, Andrew J.; Goodall, Gregory J.; Wickramasinghe, Vihandha O.
作者单位：University of Melbourne; Peter Maccallum Cancer Center; University of Melbourne; Peter Maccallum Cancer Center; University of South Australia; Centre for Cancer Biology; SA Pathology; St. Vincent's Institute of Medical Research; Southern University of Science & Technology; Southern University of Science & Technology; University of Adelaide; Friedrich Miescher Institute for Biomedical Research; University of Basel; University of Adelaide; University of Melbourne; University of Adelaide; University of Adelaide; Friedrich Miescher Institute for Biomedical Research
摘要：Circular RNAs (circRNAs), which are increasingly being implicated in a variety of functions in normal and cancerous cells(1-5), are formed by back-splicing of precursor mRNAs in the nucleus(6-10). circRNAs are predominantly localized in the cytoplasm, indicating that they must be exported from the nucleus. Here we identify a pathway that is specific for the nuclear export of circular RNA. This pathway requires Ran-GTP, exportin-2 and IGF2BP1. Enhancing the nuclear Ran-GTP gradient by depletion...
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作者：Knights, Antony; Lemasson, Anaelle; Frost, Matthew; Somerfield, Paul
作者单位：University College Cork; University of Plymouth; Plymouth Marine Laboratory; Plymouth Marine Laboratory
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作者：Stenzinger, Albrecht; Klauschen, Frederick
作者单位：Ruprecht Karls University Heidelberg; University of Munich
