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作者：O'Grady, Cathleen
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作者：Pan, Qingsong; Ding, Kunqing; Guo, Song; Lu, Ning; Tao, Nairong; Zhu, Ting; Lu, Lei
作者单位：Chinese Academy of Sciences; Institute of Metal Research, CAS; University System of Georgia; Georgia Institute of Technology; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shandong University
摘要：Cyclic creep, or ratcheting, is a severe form of fatigue deformation caused by cumulative unidirectional plastic strain under asymmetrical stress cycling with a nonzero mean stress. It often causes premature failure of structural materials, and enhancing ratcheting resistance is a challenge in materials engineering. We demonstrate superior ratcheting resistance in high-strength austenitic stainless steel with a gradient hierarchy of dislocation cells. The ratcheting rate is two to four orders ...
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作者：Wai, Jonathan
作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
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作者：Xia, Yuanxing
作者单位：Hohai University
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作者：Abdallatif, Yousef
作者单位：Necmettin Erbakan University
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作者：Elshrief, Malk
作者单位：Egyptian Knowledge Bank (EKB); Tanta University
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作者：Mervis, Jeffrey
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作者：Martin-Rufino, Jorge Diego; Caulier, Alexis; Lee, Seayoung; Castano, Nicole; King, Emily; Joubran, Samantha; Jones, Marcus; Goldman, Seth R.; Arora, Uma P.; Wahlster, Lara; Lander, Eric S.; Sankaran, Vijay G.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University
摘要：Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb-multiome, to simultaneously profile chromatin accessibility and gene expression in single cells with CRISPR-mediated perturbation of master transcription factors (TFs). We examined the connection between TFs, accessible regions, and gene expression across the genome throughout hematopoietic diffe...
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作者：Kalan, Ammie K.; Luncz, Lydia V.
作者单位：University of Victoria; Max Planck Society
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作者：Shakir, Sara
作者单位：Universite de Bordeaux; INRAE
