作者:Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Correa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Melo, Luiza Martins Nascentes; Allies, Gabriele; Roesler, Jonas; Wittenhofer, Pia; Krystkiewicz, Jonathan; Schmitz, Oliver J.; Roper, Jatin; Vinolo, Marco Aurelio Ramirez; Ricciardiello, Luigi; Lien, Evan C.; Vander Heiden, Matthew G.; Shivdasani, Ramesh A.; Cheng, Chia-Wei; Tasdogan, Alpaslan; Yilmaz, Oemer H.
作者单位:Massachusetts Institute of Technology (MIT); University of Duisburg Essen; Massachusetts Institute of Technology (MIT); Universidade de Sao Paulo; Universidade Estadual de Campinas; Universidade Estadual de Campinas; University of Bologna; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Dokuz Eylul University; University of Duisburg Essen; Helmholtz Association; German Cancer Research Center (DKFZ); Duke University; Duke University; University of Texas System; UTMD Anderson Cancer Center; Van Andel Institute; Columbia University; NewYork-Presbyterian Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要:For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1-6. However, how fasting and post-fast refeeding affect adult stem cells and tumour formation has yet to be explored in depth. Here we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation; post-fast refeeding augments the regenerative capacity of Lgr5+ ISCs, and loss of the tumour suppressor gene Apc in post-f...
作者:Tacon, Dave
摘要:Rebecca Hsu works as a forest ecologist for the Taiwan Forestry Institute in Taipei.
作者:Ng, Christine S. C.; Liu, Aofei; Cui, Bianxiao; Banik, Steven M.
作者单位:Stanford University; Stanford University
摘要:Subcellular protein localization regulates protein function and can be corrupted in cancers(1) and neurodegenerative diseases(2,3). The rewiring of localization to address disease-driving phenotypes would be an attractive targeted therapeutic approach. Molecules that harness the trafficking of a shuttle protein to control the subcellular localization of a target protein could enforce targeted protein relocalization and rewire the interactome. Here we identify a collection of shuttle proteins w...
作者:Dickopf, Stefan; Sikora, Bastian; Kaiser, Annabelle; Mueller, Marius; Ulmer, Stefan; Yerokhin, Vladimir A.; Harman, Zoltan; Keitel, Christoph H.; Mooser, Andreas; Blaum, Klaus
作者:Dolgin, Elie
摘要:Pain is defined subjectively, but an objective measure of the experience promises to transform its management
作者:Garisto, Dan
摘要:Particle measurements at the Large Hadron Collider open the door to future high-energy tests of entanglement. Particle measurements at the Large Hadron Collider open the door to future high-energy tests of entanglement.
作者:Huebner, Stefan
作者单位:National University of Singapore