作者：Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Correa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Melo, Luiza Martins Nascentes; Allies, Gabriele; Roesler, Jonas; Wittenhofer, Pia; Krystkiewicz, Jonathan; Schmitz, Oliver J.; Roper, Jatin; Vinolo, Marco Aurelio Ramirez; Ricciardiello, Luigi; Lien, Evan C.; Vander Heiden, Matthew G.; Shivdasani, Ramesh A.; Cheng, Chia-Wei; Tasdogan, Alpaslan; Yilmaz, Oemer H.
作者单位：Massachusetts Institute of Technology (MIT); University of Duisburg Essen; Massachusetts Institute of Technology (MIT); Universidade de Sao Paulo; Universidade Estadual de Campinas; Universidade Estadual de Campinas; University of Bologna; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Dokuz Eylul University; University of Duisburg Essen; Helmholtz Association; German Cancer Research Center (DKFZ); Duke University; Duke University; University of Texas System; UTMD Anderson Cancer Center; Van Andel Institute; Columbia University; NewYork-Presbyterian Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1-6. However, how fasting and post-fast refeeding affect adult stem cells and tumour formation has yet to be explored in depth. Here we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation; post-fast refeeding augments the regenerative capacity of Lgr5+ ISCs, and loss of the tumour suppressor gene Apc in post-f...
作者：Tacon, Dave
摘要：Rebecca Hsu works as a forest ecologist for the Taiwan Forestry Institute in Taipei.
作者：Ng, Christine S. C.; Liu, Aofei; Cui, Bianxiao; Banik, Steven M.
作者单位：Stanford University; Stanford University
摘要：Subcellular protein localization regulates protein function and can be corrupted in cancers(1) and neurodegenerative diseases(2,3). The rewiring of localization to address disease-driving phenotypes would be an attractive targeted therapeutic approach. Molecules that harness the trafficking of a shuttle protein to control the subcellular localization of a target protein could enforce targeted protein relocalization and rewire the interactome. Here we identify a collection of shuttle proteins w...
作者：Dickopf, Stefan; Sikora, Bastian; Kaiser, Annabelle; Mueller, Marius; Ulmer, Stefan; Yerokhin, Vladimir A.; Harman, Zoltan; Keitel, Christoph H.; Mooser, Andreas; Blaum, Klaus
作者：Dolgin, Elie
摘要：Pain is defined subjectively, but an objective measure of the experience promises to transform its management
作者：Garisto, Dan
摘要：Particle measurements at the Large Hadron Collider open the door to future high-energy tests of entanglement. Particle measurements at the Large Hadron Collider open the door to future high-energy tests of entanglement.
作者：Huebner, Stefan
作者单位：National University of Singapore
