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作者：Mallapaty, Smriti
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作者：Lavillegrand, Jean-Remi; Al-Rifai, Rida; Thietart, Sara; Guyon, Theo; Vandestienne, Marie; Cohen, Raphael; Duval, Vincent; Zhong, Xiaodan; Yen, Daniel; Ozturk, Mumin; Negishi, Yutaka; Konkel, Joanne; Pinteaux, Emmanuel; Lenoir, Olivia; Vilar, Jose; Laurans, Ludivine; Esposito, Bruno; Bredon, Marius; Sokol, Harry; Diedisheim, Marc; Saliba, Antoine-Emmanuel; Zernecke, Alma; Cochain, Clement; Haub, Jessica; Tedgui, Alain; Speck, Nancy A.; Taleb, Soraya; Mhlanga, Musa M.; Schlitzer, Andreas; Riksen, Niels P.; Ait-Oufella, Hafid
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; University of Bonn; University of Pennsylvania; University of Pennsylvania; Radboud University Nijmegen; University of Manchester; University of Manchester; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); AgroParisTech; Universite Paris Saclay; INRAE; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; Radboud University Nijmegen; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP
摘要：Systemic immune responses caused by chronic hypercholesterolaemia contribute to atherosclerosis initiation, progression and complications1. However, individuals often change their dietary habits over time2, and the effects of an alternating high-fat diet (HFD) on atherosclerosis remain unclear. Here, to address this relevant issue, we developed a protocol using atherosclerosis-prone mice to compare an alternating versus continuous HFD while maintaining similar overall exposure periods. We foun...
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作者：Baldi, Pierre; Fariselli, Piero; Parisi, Giorgio
作者单位：University of California System; University of California Irvine; University of Turin; Sapienza University Rome
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作者：Mccullom, Rod
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作者：Biniaris-Georgallis, Stylianos-Iason; Aschman, Tom; Stergioula, Katerina; Schreiber, Frauke; Jafari, Vajiheh; Taranko, Anna; Karmalkar, Tejal; Kasapi, Ana; Lenac Rovis, Tihana; Jelencic, Vedrana; Bejarano, David A.; Fabry, Lea; Papacharalampous, Michail; Mattiola, Irene; Molgora, Martina; Hou, Jinchao; Hublitz, Karolin W.; Heinrich, Frederik; Guerra, Gabriela Maria; Durek, Pawel; Patone, Giannino; Lindberg, Eric L.; Maatz, Henrike; Hoelsken, Oliver; Kroenke, Gerhard; Mortha, Arthur; Voll, Reinhard E.; Clarke, Alexander J.; Hauser, Anja E.; Colonna, Marco; Thurley, Kevin; Schlitzer, Andreas; Schneider, Christoph; Stamatiades, Efstathios G.; Mashreghi, Mir-Farzin; Jonjic, Stipan; Huebner, Norbert; Diefenbach, Andreas; Kanda, Masatoshi; Triantafyllopoulou, Antigoni
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; University of Freiburg; University of Rijeka; University of Bonn; Washington University (WUSTL); Helmholtz Association; Max Delbruck Center for Molecular Medicine; German Centre for Cardiovascular Research; University of Toronto; University of Oxford; Kennedy Institute for Rheumatology; University of Bonn; University of Zurich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Sapporo Medical University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; H Lee Moffitt Cancer Center & Research Institute; Zhejiang University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health
摘要：In systemic lupus erythematosus, loss of immune tolerance, autoantibody production and immune complex deposition are required but not sufficient for organ damage1. How inflammatory signals are initiated and amplified in the setting of autoimmunity remains elusive. Here we set out to dissect layers and hierarchies of autoimmune kidney inflammation to identify tissue-specific cellular hubs that amplify autoinflammatory responses. Using high-resolution single-cell profiling of kidney immune and p...
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作者：Dathathri, Sumanth; See, Abigail; Ghaisas, Sumedh; Huang, Po-Sen; McAdam, Rob; Welbl, Johannes; Bachani, Vandana; Kaskasoli, Alex; Stanforth, Robert; Matejovicova, Tatiana; Hayes, Jamie; Vyas, Nidhi; Al Merey, Majd; Brown-Cohen, Jonah; Bunel, Rudy; Balle, Borja; Cemgil, Taylan; Ahmed, Zahra; Stacpoole, Kitty; Shumailov, Ilia; Baetu, Ciprian; Gowal, Sven; Hassabis, Demis; Kohli, Pushmeet
作者单位：Alphabet Inc.; DeepMind; Google Incorporated; Alphabet Inc.; Google Incorporated
摘要：Large language models (LLMs) have enabled the generation of high-quality synthetic text, often indistinguishable from human-written content, at a scale that can markedly affect the nature of the information ecosystem1-3. Watermarking can help identify synthetic text and limit accidental or deliberate misuse4, but has not been adopted in production systems owing to stringent quality, detectability and computational efficiency requirements. Here we describe SynthID-Text, a production-ready text ...
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作者：Huang, Lulu; Bernink, Jochem H.; Giladi, Amir; Krueger, Daniel; van Son, Gijs J. F.; Geurts, Maarten H.; Busslinger, Georg; Lin, Lin; Begthel, Harry; Zandvliet, Maurice; Buskens, Christianne J.; Bemelman, Willem A.; Lopez-Iglesias, Carmen; Peters, Peter J.; Clevers, Hans
作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); University of Amsterdam; Princess Maxima Center; Utrecht University; University of Amsterdam; Maastricht University
摘要：In mice, intestinal tuft cells have been described as a long-lived, postmitotic cell type. Two distinct subsets have been identified: tuft-1 and tuft-2 (ref. 1). By combining analysis of primary human intestinal resection material and intestinal organoids, we identify four distinct human tuft cell states, two of which overlap with their murine counterparts. We show that tuft cell development depends on the presence of Wnt ligands, and that tuft cell numbers rapidly increase on interleukin-4 (I...
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作者：Rawson, James R. G.; Martinelli, Agustin G.; Gill, Pamela G.; Soares, Marina B.; Schultz, Cesar L.; Rayfield, Emily J.
作者单位：University of Bristol; Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Natural History Museum London; Universidade Federal do Rio de Janeiro; Universidade Federal do Rio Grande do Sul
摘要：The acquisition of the load-bearing dentary-squamosal jaw joint was a key step in mammalian evolution1-5. Although this innovation has received decades of study, questions remain over when and how frequently a mammalian-like skull-jaw contact evolved, hindered by a paucity of three-dimensional data spanning the non-mammaliaform cynodont-mammaliaform transition. New discoveries of derived non-mammaliaform probainognathian cynodonts from South America have much to offer to this discussion. Here,...
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作者：Tollefson, Jeff; Van Noorden, Richard
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作者：Schroter, Christian
作者单位：Leiden University; Leiden University - Excl LUMC
摘要：An unexpected link has been found between the metabolic pathways that produce energy for embryo growth, and the cellular signalling systems that regulate cell specialization and movement during early development.
