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作者：Doughty, Benjamin R.; Hinks, Michaela M.; Schaepe, Julia M.; Marinov, Georgi K.; Thurm, Abby R.; Rios-Martinez, Carolina; Parks, Benjamin E.; Tan, Yingxuan; Marklund, Emil; Dubocanin, Danilo; Bintu, Lacramioara; Greenleaf, William J.
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stockholm University; Stanford University
摘要：The binding of multiple transcription factors (TFs) to genomic enhancers drives gene expression in mammalian cells1. However, the molecular details that link enhancer sequence to TF binding, promoter state and transcription levels remain unclear. Here we applied single-molecule footprinting2,3 to measure the simultaneous occupancy of TFs, nucleosomes and other regulatory proteins on engineered enhancer-promoter constructs with variable numbers of TF binding sites for both a synthetic TF and an...
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作者：Pulit-Penaloza, Joanna A.; Belser, Jessica A.; Brock, Nicole; Kieran, Troy J.; Sun, Xiangjie; Pappas, Claudia; Zeng, Hui; Carney, Paul; Chang, Jessie; Bradley-Ferrell, Brandon; Stevens, James; de la Cruz, Juan A.; Hatta, Yasuko; Di, Han; Davis, C. Todd; Tumpey, Terrence M.; Maines, Taronna R.
作者单位：Centers for Disease Control & Prevention - USA; CDC National Center for Immunization & Respiratory Diseases (NCIRD)
摘要：Since 2020, there has been unprecedented global spread of highly pathogenic avian influenza A(H5N1) in wild bird populations with spillover into a variety of mammalian species and sporadically humans1. In March 2024, clade 2.3.4.4b A(H5N1) virus was first detected in dairy cattle in the USA, with subsequent detection in numerous states2, leading to more than a dozen confirmed human cases3,4. In this study, we used the ferret, a well-characterized animal model that permits concurrent investigat...
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作者：Tregoning, John; Tillotson, Richard
作者单位：Imperial College London
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作者：Gittes, Ruben F.; Rist, Marcus; Treves, Salvador; Biewener, Andrew
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
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作者：Jee, Justin; Fong, Christopher; Pichotta, Karl; Tran, Thinh Ngoc; Luthra, Anisha; Waters, Michele; Fu, Chenlian; Altoe, Mirella; Liu, Si-Yang; Maron, Steven B.; Ahmed, Mehnaj; Kim, Susie; Pirun, Mono; Chatila, Walid K.; de Bruijn, Ino; Pasha, Arfath; Kundra, Ritika; Gross, Benjamin; Mastrogiacomo, Brooke; Aprati, Tyler J.; Liu, David; Gao, Jianjiong; Capelletti, Marzia; Pekala, Kelly; Loudon, Lisa; Perry, Maria; Bandlamudi, Chaitanya; Donoghue, Mark; Satravada, Baby Anusha; Martin, Axel; Shen, Ronglai; Chen, Yuan; Brannon, A. Rose; Chang, Jason; Braunstein, Lior; Li, Anyi; Safonov, Anton; Stonestrom, Aaron; Sanchez-Vela, Pablo; Wilhelm, Clare; Robson, Mark; Scher, Howard; Ladanyi, Marc; Reis-Filho, Jorge S.; Solit, David B.; Jones, David R.; Gomez, Daniel; Yu, Helena; Chakravarty, Debyani; Yaeger, Rona; Abida, Wassim; Park, Wungki; O'Reilly, Eileen M.; Garcia-Aguilar, Julio; Socci, Nicholas; Sanchez-Vega, Francisco; Carrot-Zhang, Jian; Stetson, Peter D.; Levine, Ross; Rudin, Charles M.; Berger, Michael F.; Shah, Sohrab P.; Schrag, Deborah; Razavi, Pedram; Kehl, Kenneth L.; Li, Bob T.; Riely, Gregory J.; Schultz, Nikolaus; MSK Canc Data Sci Initiative Grp, Aaron
作者单位：Memorial Sloan Kettering Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Cornell University; Weill Cornell Medicine
摘要：The digitization of health records and growing availability of tumour DNA sequencing provide an opportunity to study the determinants of cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text and siloed datasets. Here we combine natural language processing annotations1,2 with structured medication, patient-reported demographic, tumour registry and tumour genomic data from 24,950 patients at Memorial Sloan Kettering Cancer Center to generate a clinicogen...
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作者：Saher, Saliha; Johnston, Sam; Esther-Kelvin, Ratu; Pringle, Jennifer M.; Macfarlane, Douglas R.; Matuszek, Karolina
作者单位：Monash University; Deakin University
摘要：The global aim to move away from fossil fuels requires efficient, inexpensive and sustainable energy storage to fully use renewable energy sources. Thermal energy storage materials1,2 in combination with a Carnot battery3, 4-5 could revolutionize the energy storage sector. However, a lack of stable, inexpensive and energy-dense thermal energy storage materials impedes the advancement of this technology. Here we report the first, to our knowledge, 'trimodal' material that synergistically stores...
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作者：Knight, Christopher G.; Nicolitch, Oceane; Griffiths, Rob I.; Goodall, Tim; Jones, Briony; Weser, Carolin; Langridge, Holly; Davison, John; Dellavalle, Ariane; Eisenhauer, Nico; Gongalsky, Konstantin B.; Hector, Andrew; Jardine, Emma; Kardol, Paul; Maestre, Fernando T.; Schaedler, Martin; Semchenko, Marina; Stevens, Carly; Tsiafouli, Maria A.; Vilhelmsson, Oddur; Wanek, Wolfgang; de Vries, Franciska T.
作者单位：University of Manchester; Bangor University; UK Centre for Ecology & Hydrology (UKCEH); UK Centre for Ecology & Hydrology (UKCEH); University of Tartu; Tartu University Institute of Ecology & Earth Sciences; University of Manchester; Imperial College London; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; Russian Academy of Sciences; Saratov Scientific Center of the Russian Academy of Sciences; Severtsov Institute of Ecology & Evolution; University of Oxford; University of Sheffield; Swedish University of Agricultural Sciences; Swedish University of Agricultural Sciences; King Abdullah University of Science & Technology; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Lancaster University; Aristotle University of Thessaloniki; University of Akureyri; University of Iceland; University of Vienna; University of Amsterdam
摘要：Increasing extreme climatic events threaten the functioning of terrestrial ecosystems1,2. Because soil microbes govern key biogeochemical processes, understanding their response to climate extremes is crucial in predicting the consequences for ecosystem functioning3,4. Here we subjected soils from 30 grasslands across Europe to four contrasting extreme climatic events under common controlled conditions (drought, flood, freezing and heat), and compared the response of soil microbial communities...
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作者：El-Gaby, Mohamady; Harris, Adam Loyd; Whittington, James C. R.; Dorrell, William; Bhomick, Arya; Walton, Mark E.; Akam, Thomas; Behrens, Timothy E. J.
作者单位：University of Oxford; University of Oxford; University of Oxford; Stanford University; University of London; University College London; University of London; University College London
摘要：To flexibly adapt to new situations, our brains must understand the regularities in the world, as well as those in our own patterns of behaviour. A wealth of findings is beginning to reveal the algorithms that we use to map the outside world1-6. However, the biological algorithms that map the complex structured behaviours that we compose to reach our goals remain unknown. Here we reveal a neuronal implementation of an algorithm for mapping abstract behavioural structure and transferring it to ...
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作者：Ilyas, Batyr; Luo, Tianchuang; von Hoegen, Alexander; Bostrom, Emil Vinas; Zhang, Zhuquan; Park, Jaena; Kim, Junghyun; Park, Je-Geun; Nelson, Keith A.; Rubio, Angel; Gedik, Nuh
作者单位：Massachusetts Institute of Technology (MIT); Max Planck Society; University of Basque Country; Massachusetts Institute of Technology (MIT); Seoul National University (SNU); Seoul National University (SNU); Simons Foundation; Flatiron Institute
摘要：Controlling the functional properties of quantum materials with light has emerged as a frontier of condensed-matter physics, leading to the discovery of various light-induced phases of matter, such as superconductivity1, ferroelectricity2,3, magnetism4, 5-6 and charge density waves7. However, in most cases, the photoinduced phases return to equilibrium on ultrafast timescales after the light is turned off, limiting their practical applications. Here we use intense terahertz pulses to induce a ...
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作者：Kwon, Diana
