8071期

最新文章

• Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome (vol 610, pg 366, 2022) AI翻译
  作者：Su, Hua; Yang, Fei; Fu, Rao; Trinh, Brittney; Sun, Nina; Liu, Junlai; Kumar, Avi; Baglieri, Jacopo; Siruno, Jeremy; Le, Michelle; Li, Yuhan; Dozier, Stephen; Nair, Ajay; Filliol, Aveline; Sinchai, Nachanok; Rosenthal, Sara Brin; Santini, Jennifer; Metallo, Christian M.; Molina, Anthony; Schwabe, Robert F.; Lowy, Andrew M.; Brenner, David A.; Sun, Beicheng; Karin, Michael
• Human de novo mutation rates from a four-generation pedigree reference AI翻译
  作者：Porubsky, David; Dashnow, Harriet; Sasani, Thomas A.; Logsdon, Glennis A.; Hallast, Pille; Noyes, Michelle D.; Kronenberg, Zev N.; Mokveld, Tom; Koundinya, Nidhi; Nolan, Cillian; Steely, Cody J.; Guarracino, Andrea; Dolzhenko, Egor; Harvey, William T.; Rowell, William J.; Grigorev, Kirill; Nicholas, Thomas J.; Goldberg, Michael E.; Oshima, Keisuke K.; Lin, Jiadong; Ebert, Peter; Watkins, W. Scott; Leung, Tiffany Y.; Hanlon, Vincent C. T.; McGee, Sean; Pedersen, Brent S.; Happ, Hannah C.; Jeong, Hyeonsoo; Munson, Katherine M.; Hoekzema, Kendra; Chan, Daniel D.; Wang, Yanni; Knuth, Jordan; Garcia, Gage H.; Fanslow, Cairbre; Lambert, Christine; Lee, Charles; Smith, Joshua D.; Levy, Shawn; Mason, Christopher E.; Garrison, Erik; Lansdorp, Peter M.; Neklason, Deborah W.; Jorde, Lynn B.; Quinlan, Aaron R.; Eberle, Michael A.; Eichler, Evan E.
  作者单位：University of Washington; University of Washington Seattle; Utah System of Higher Education; University of Utah; University of Colorado System; University of Colorado Anschutz; Jackson Laboratory; University of Kentucky; University of Tennessee System; University of Tennessee Health Science Center; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; University of Pennsylvania; Pennsylvania Medicine; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Heinrich Heine University Dusseldorf; British Columbia Cancer Agency; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of British Columbia; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
  摘要：Understanding the human de novo mutation (DNM) rate requires complete sequence information1. Here using five complementary short-read and long-read sequencing technologies, we phased and assembled more than 95% of each diploid human genome in a four-generation, twenty-eight-member family (CEPH 1463). We estimate 98-206 DNMs per transmission, including 74.5 de novo single-nucleotide variants, 7.4 non-tandem repeat indels, 65.3 de novo indels or structural variants originating from tandem repeat...
• Water abundance in the lunar farside mantle AI翻译
  作者：He, Huicun; Li, Linxi; Hu, Sen; Gao, Yubing; Gao, Liang; Zhou, Zhan; Qiu, Mengfan; Zhou, Disheng; Liu, Huanxin; Li, Ruiying; Hao, Jialong; Hui, Hejiu; Lin, Yangting
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanjing University; Nanjing University
  摘要：The water contents of the lunar interior record important clues for understanding the formation and subsequent thermochemical evolution of the Moon(1). The Chang'e-6 (CE6) mission returned samples from the South Pole-Aitken impact basin of the lunar farside(2-4), providing an opportunity to study the water contents of the farside mantle. Here we report the water abundances and hydrogen isotope compositions of apatite and melt inclusions from CE6 mare basalt, derived from partial melting of the...
• Obesity drugs made in China could power next wave of treatments AI翻译
  作者：Fieldhouse, Rachel
• Nanoplastics make up most of the plastic pollutants in the North Atlantic Ocean AI翻译
  作者：Pabortsava, Katsiaryna
  作者单位：NERC National Oceanography Centre
• Regulatory genomic circuitry of human disease loci by integrative epigenomics (vol 590, pg 300, 2021) AI翻译
  作者：Boix, Carles A.; James, Benjamin T.; Park, Yongjin P.; Meuleman, Wouter; Kellis, Manolis
• Clonal tracing with somatic epimutations reveals dynamics of blood ageing AI翻译
  作者：Scherer, Michael; Singh, Indranil; Maria Braun, Martina; Szu-Tu, Chelsea; Sanchez Sanchez, Pedro; Lindenhofer, Dominik; Jakobsen, Niels Asger; Korber, Verena; Kardorff, Michael; Nitsch, Lena; Kautz, Pauline; Ruhle, Julia; Bianchi, Agostina; Cozzuto, Luca; Fromel, Robert; Beneyto-Calabuig, Sergi; Lareau, Caleb; Satpathy, Ansuman T.; Beekman, Renee; Steinmetz, Lars M.; Raffel, Simon; Ludwig, Leif S.; Vyas, Paresh; Rodriguez-Fraticelli, Alejo; Velten, Lars
  作者单位：Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); Helmholtz Association; German Cancer Research Center (DKFZ); Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Barcelona; Pompeu Fabra University; European Molecular Biology Laboratory (EMBL); German Centre for Cardiovascular Research; University of Oxford; Ruprecht Karls University Heidelberg; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Free University of Berlin; Technical University of Berlin; Memorial Sloan Kettering Cancer Center; Stanford University; Stanford Medicine; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Stanford University; Stanford Medicine; Stanford University; ICREA
  摘要：Current approaches used to track stem cell clones through differentiation require genetic engineering(1,2) or rely on sparse somatic DNA variants(3,4), which limits their wide application. Here we discover that DNA methylation of a subset of CpG sites reflects cellular differentiation, whereas another subset undergoes stochastic epimutations and can serve as digital barcodes of clonal identity. We demonstrate that targeted single-cell profiling of DNA methylation(5) at single-CpG resolution ca...
• Rubbish years: how to boost lab group morale when world events crash in AI翻译
  作者：Boeck, N. G.
• First samples from the Moon's 'dark side' AI翻译
  作者：Elardo, Stephen M.
  作者单位：State University System of Florida; University of Florida
• The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour AI翻译
  作者：Yoshida, Tomomi M.; Nguyen, Mytien; Zhang, Le; Lu, Benjamin Y.; Zhu, Biqing; Murray, Katie N.; Mineur, Yann S.; Zhang, Cuiling; Xu, Di; Lin, Elizabeth; Luchsinger, Joseph; Bhatta, Sagar; Waizman, Daniel A.; Coden, Mackenzie E.; Ma, Yifan; Israni-Winger, Kavita; Russo, Anthony; Wang, Haowei; Song, Wenzhi; Al Souz, Jafar; Zhao, Hongyu; Craft, Joseph E.; Picciotto, Marina R.; Grutzendler, Jaime; Distasio, Marcello; Palm, Noah W.; Hafler, David A.; Wang, Andrew
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells1. The contribution of the innate immune compartment in the meninges and the central nervous system (CNS) is well-characterized; however, whether cells of the adaptive immune system reside in the brain and are involved in maintaining homeostasis is unclear2, 3-4. Here we show that the subfornical organ (SFO) of the brain is a nucleus for parenchymal alpha beta T cells...