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作者：Liu, Jia-Cheng; Wang, Dongpeng; Callen, Elsa; Chen, Chuanyuan; Noriega, Santiago; Shang, Yafang; Schurmann, David; Song, Yawei; Ramadoss, Gokul N.; Chari, Raj; Wong, Nancy; Zhao, Yongge; He, Yuan; Aplan, Peter D.; Ward, Michael E.; Heintz, Nathaniel; Rao, Anjana; McKinnon, Peter J.; Caldecott, Keith W.; Schar, Primo; Meng, Fei-Long; Livak, Ferenc; Wu, Wei; Nussenzweig, Andre
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Basel; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; University of California System; University of California San Francisco; The J David Gladstone Institutes; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Johns Hopkins University; Johns Hopkins University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Rockefeller University; Howard Hughes Medical Institute; La Jolla Institute for Immunology; St Jude Children's Research Hospital; University of Sussex; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Center for Excellence in Molecular Cell Science, CAS; Chinese Academy of Sciences; Institute of Biophysics, CAS
摘要：Postmitotic neurons have high levels of methylated cytosine and its oxidized intermediates such as 5-hydroxymethylcytosine1. However, the functional relevance of these epigenetic modifications of DNA are poorly understood. Here we show that some cytidine analogues, such as cytarabine, cause DNA double-strand breaks during TET-mediated active 5-methylcytosine demethylation by interrupting TDG-dependent base excision repair. These double-strand breaks are frequently converted into deletions and ...
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作者：Chen, Kelvin Y.; Kibayashi, Tatsuya; Giguelay, Ambre; Hata, Mayu; Nakajima, Shunsuke; Mikami, Norihisa; Takeshima, Yusuke; Ichiyama, Kenji; Omiya, Ryusuke; Ludwig, Leif S.; Hattori, Kunihiro; Sakaguchi, Shimon
作者单位：University of Osaka; University of Osaka; Chugai Pharmaceutical Co., Ltd.; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Kyoto University
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作者：Rademaker, Gilles; Hernandez, Grace A.; Seo, Yurim; Dahal, Sumena; Miller-Phillips, Lisa; Li, Alexander L.; Peng, Xianlu Laura; Luan, Changfei; Qiu, Longhui; Liegeois, Maude A.; Wang, Bruce; Wen, Kwun W.; Kim, Grace E.; Collisson, Eric A.; Kruger, Stephan F.; Boeck, Stefan; Ormanns, Steffen; Guenther, Michael; Heinemann, Volker; Haas, Michael; Looney, Mark R.; Yeh, Jen Jen; Zoncu, Roberto; Perera, Rushika M.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of Munich; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Fred Hutchinson Cancer Center; Helmholtz Association; German Cancer Research Center (DKFZ); Medical University of Innsbruck; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California Berkeley
摘要：To grow at distant sites, metastatic cells must overcome major challenges posed by the unique cellular and metabolic composition of secondary organs1. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that metastasizes to the liver and lungs. Despite evidence of metabolic reprogramming away from the primary site, the key drivers that dictate the ability of PDAC cells to colonize the liver or lungs and survive there remain undefined. Here we identified PCSK9 as predictive of live...
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作者：Conroy, Gemma
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作者：Roh, Sangchul; Ha, Youlim; Abbott, Nicholas L.
作者单位：Cornell University; Chonnam National University
摘要：Liquids comprising two coexisting phases can form a range of stable and metastable states, including wetting films, droplets and threads(1, 2-3). Processes that permit rapid and reversible transformations between these morphologies, however, have been difficult to realize because physical properties required for rapid shape change (for example, low interfacial tension or viscosity) provide pathways for relaxation that result in short-lived states. Fully reversible formation of long-lived micro...
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作者：Wu, Jingjing; Deng, Jue; Theocharidis, Georgios; Sarrafian, Tiffany L.; Griffiths, Leigh G.; Bronson, Roderick T.; Veves, Aristidis; Chen, Jianzhu; Yuk, Hyunwoo; Zhao, Xuanhe
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作者：Liu, Bingbing
作者单位：Jilin University
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作者：Robinson, Andrew
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作者：Ji, Haijin; Xiang, Jingwei; Li, Yong; Zheng, Mengting; Yuan, Lixia; Liao, Yaqi; Du, Lin; Li, Zezhuo; Xie, Zhangyating; Huang, Kai; Lin, Xing; Xie, Zhengkun; Shen, Yue; Chen, Ming; Li, Tongjiang; Feng, Guang; Sun, Yongming; Qie, Long; Li, Hui; Zhang, Fangshu; Guo, Rui; Feng, Xuning; Chen, Weihua; Ai, Xinping; Lu, Jun; Huang, Yunhui
作者单位：Huazhong University of Science & Technology; Zhejiang University; Zhengzhou University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Wuhan University; Tsinghua University
摘要：A lithium (Li)-metal anode paired with a high-nickel cathode is considered to be a combination that holds promise to surpass the 500 Wh kg-1 threshold1,2. Approaching such high energy density, electrolytes capable of stabilizing both anode and cathode interphases are of importance to secure safe and long-term cycling3,4. Although anion-derived inorganic interphases have shown remarkable success at the Li side5, 6-7, developing intrinsic strategies to concurrently protect both electrodes remain...
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作者：Zhu, Kun; Reid, Obadiah; Rangan, Sylvie; Wang, Li; Li, Jingbai; Durai, Kevin Antony Jesu; Zhou, Kang; Javed, Nasir; Kasaei, Leila; Yang, Chongqing; Li, Mingxing; Sun, Yue; Tan, Kui; Cotlet, Mircea; Liu, Yi; Feldman, Leonard C.; O'Carroll, Deirdre M.; Zhu, Kai; Li, Jing
作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; Shenzhen Polytechnic University; University of North Texas System; University of North Texas Denton; Rutgers University System; Rutgers University New Brunswick; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory
摘要：Solution-processed light-emitting diodes based on non-toxic copper-iodide hybrids1 are a compelling solution for efficient and stable deep-blue lighting, owing to their tunability, high photoluminescence efficiency and environmental sustainability2. Here we present a hybrid copper-iodide that shows near-unity photoluminescence quantum yield (99.6%) with an emission wavelength of 449 nm and colour coordinates (0.147, 0.087), alongside its emission mechanism and charge transport characteristics....
