8076期

最新文章

• Is gravity quantum? Experiments could finally probe one of physics' biggest questions AI翻译
  作者：Castelvecchi, Davide
• Molecular gradients shape synaptic specificity of a visuomotor transformation AI翻译
  作者：Dombrovski, Mark; Zang, Yixin; Frighetto, Giovanni; Vaccari, Andrea; Jang, HyoJong; Mirshahidi, Parmis S.; Xie, Fangming; Sanfilippo, Piero; Hina, Bryce W.; Rehan, Aadil; Hussein, Roni H.; Mirshahidi, Pegah S.; Lee, Catherine; Morris, Aileen; Frye, Mark A.; von Reyn, Catherine R.; Kurmangaliyev, Yerbol Z.; Card, Gwyneth M.; Zipursky, S. Lawrence
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; Columbia University; Howard Hughes Medical Institute; University of California System; University of California Los Angeles; Middlebury College; Drexel University; Brandeis University
  摘要：How does the brain convert visual input into specific motor actions(1,2)? In Drosophila, visual projection neurons (VPNs)(3,4) perform this visuomotor transformation by converting retinal positional information into synapse number in the brain(5). The molecular basis of this phenomenon remains unknown. We addressed this issue in LPLC2 (ref. 6), a VPN type that detects looming motion and preferentially drives escape behaviour to stimuli approaching from the dorsal visual field with progressivel...
• Monoclonal antibodies revolutionized biomedical science and health care AI翻译
  作者：[Anonymous]
  摘要：The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
• Rubber planting and deforestation AI翻译
  作者：Sheil, Douglas; Descals, Adria; Meijaard, Erik; Gaveau, David
  作者单位：Wageningen University & Research; CGIAR; Center for International Forestry Research (CIFOR); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Sunway University
• Pathology-oriented multiplexing enables integrative disease mapping AI翻译
  作者：Kuehl, Malte; Okabayashi, Yusuke; Wong, Milagros N.; Gernhold, Lukas; Gut, Gabriele; Kaiser, Nico; Schwerk, Maria; Graefe, Stefanie K.; Ma, Frank Y.; Tanevski, Jovan; Schaefer, Philipp S. L.; Mezher, Sam; del Castillo, Jacobo Sarabia; Goldbeck-Strieder, Thiago; Zolotareva, Olga; Hartung, Michael; Chaves, Fernando M. Delgado; Klinkert, Lukas; Gnirck, Ann-Christin; Spehr, Marc; Fleck, David; Joodaki, Mehdi; Parra, Victor; Shaigan, Mina; Diebold, Martin; Prinz, Marco; Kranz, Jennifer; Kux, Johan M.; Braun, Fabian; Kretz, Oliver; Wu, Hui; Grahammer, Florian; Heins, Sven; Zimmermann, Marina; Haas, Fabian; Kylies, Dominik; Wanner, Nicola; Czogalla, Jan; Dumoulin, Bernhard; Zolotarev, Nikolay; Lindenmeyer, Maja; Karlson, Pall; Nyengaard, Jens R.; Sebode, Marcial; Weidemann, Soeren; Wiech, Thorsten; Groene, Hermann-Josef; Tomas, Nicola M.; Meyer-Schwesinger, Catherine; Kuppe, Christoph; Kramann, Rafael; Karras, Alexandre; Bruneval, Patrick; Tharaux, Pierre-Louis; Pastene, Diego; Yard, Benito; Schaub, Jennifer A.; McCown, Phillip J.; Pyle, Laura; Choi, Ye Ji; Yokoo, Takashi; Baumbach, Jan; Saez, Pablo J.; Costa, Ivan; Turner, Jan-Eric; Hodgin, Jeffrey B.; Saez-Rodriguez, Julio; Huber, Tobias B.; Bjornstad, Petter; Kretzler, Matthias; Lenoir, Olivia; Nikolic-Paterson, David J.; Pelkmans, Lucas; Bonn, Stefan; Puelles, Victor G.
  作者单位：Aarhus University; Aarhus University; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Jikei University; University of Zurich; University of Zurich; University Zurich Hospital; University of Zurich; Monash University; Monash Medical Centre; Monash University; Monash Medical Centre; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; University of Hamburg; Technical University of Munich; EUROIMMUN; RWTH Aachen University; RWTH Aachen University; University of Freiburg; University of Freiburg; RWTH Aachen University; RWTH Aachen University Hospital; Martin Luther University Halle Wittenberg; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Aarhus University; Aarhus University; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Philipps University Marburg; University of Hamburg; University Medical Center Hamburg-Eppendorf; RWTH Aachen University; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Ruprecht Karls University Heidelberg; University of Michigan System; University of Michigan; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Southern Denmark; University of Michigan System; University of Michigan
  摘要：The expression and location of proteins in tissues represent key determinants of health and disease. Although recent advances in multiplexed imaging have expanded the number of spatially accessible proteins(1-3), the integration of biological layers (that is, cell structure, subcellular domains and signalling activity) remains challenging. This is due to limitations in the compositions of antibody panels and image resolution, which together restrict the scope of image analysis. Here we present...
• Extreme river flood exposes latent erosion risk AI翻译
  作者：Barneveld, H. J.; Frings, R. M.; Mosselman, E.; Venditti, J. G.; Kleinhans, M. G.; Blom, A.; Schielen, R. M. J.; Toonen, W. H. J.; Meijer, D.; Paarlberg, A. J.; van Denderen, R. P.; de Jong, J. S.; Beemster, J. G. W.; Melsen, L. A.; Hoitink, A. J. F.
  作者单位：Wageningen University & Research; Deltares; Delft University of Technology; Simon Fraser University; Utrecht University; Vrije Universiteit Amsterdam
  摘要：Climate change is expected to increase the frequency and magnitude of river floods(1). Floods not only cause damage by inundation and loss of life(2,3) but also jeopardize infrastructure because of bank failure and riverbed erosion processes that are poorly understood. Common flood safety programmes include dyke reinforcement and river widening(4, 5, 6, 7, 8-9). The 2021 flood in the Meuse Basin caused 43 fatalities and billions of dollars of damage to infrastructure(10). Here, on the basis of...
• Preoptic EP3R neurons constitute a two-way switch for fever and torpor AI翻译
  作者：Machado, Natalia L. S.; Lynch, Nicole; Costa, Luis H. A.; Melville, David; Kucukdereli, Hakan; Kaur, Satvinder; Banks, Alexander S.; Raffin, Francesca; Ramirez-Plascencia, Oscar D.; Aten, Sydney; Lima, Janayna D.; Bandaru, Sathyajit S.; Palmiter, Richard D.; Saper, Clifford B.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Universidade de Sao Paulo; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; University of Pavia; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Many species use a temporary decrease in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity in a cool environment. Torpor is caused by preoptic neurons that express a variety of peptides and receptors(1-7), but no single genetic marker has been found for this population. Here we report that expression of the prostaglandin EP3 receptor (EP3R) marks a unique population of median preoptic nucleus (MnPO) neurons that are required for both torpor and lipopolysacchar...
• Organs on chips could make biomedical research more equitable AI翻译
  作者：del Valle, Andrea C.
  作者单位：Universidad del Valle de Guatemala
• Google AI model mines trillions of images to create maps of Earth 'at any place and time' AI翻译
  作者：Tollefson, Jeff
• Synthesis of bulk hexagonal diamond AI翻译
  作者：Yang, Liuxiang; Lau, Kah Chun; Zeng, Zhidan; Zhang, Dongzhou; Tang, Hu; Yan, Bingmin; Niu, Guoliang; Gou, Huiyang; Yang, Yanping; Yang, Wenge; Luo, Duan; Mao, Ho-kwang
  作者单位：California State University System; California State University Northridge; University of Chicago; Chinese Academy of Sciences; Xi'an Institute of Optics & Precision Mechanics, CAS
  摘要：Hexagonal diamond (HD), with anticipated physical properties superior than the known cubic diamond, has been pursued relentlessly since its inception 60 years ago(1). However, natural and synthetic HD has only been preserved as a highly disordered component in fragile, heterogeneous mixtures of other nanocarbon structures that precludes determination of bulk properties and identification of HD as a bona fide crystalline phase(2-4). Here we report the synthesis, recovery and extensive character...