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作者：Zhang, Tao; Xu, Daichao; Trefts, Elijah; Lv, Mingming; Inuzuka, Hiroyuki; Song, Guobin; Liu, Min; Lu, Jianlin; Liu, Jianping; Chu, Chen; Wang, Min; Wang, Huibing; Meng, Huyan; Liu, Hui; Zhuang, Yuan; Xie, Xingxing; Dang, Fabin; Guan, Dongxian; Men, Yuqin; Jiang, Shuwen; Jiang, Cong; Dai, Xiaoming; Liu, Jing; Wang, Zhen; Yan, Peiqiang; Wang, Jingchao; Tu, Zhenbo; Babuta, Mrigya; Erickson, Emily; Hillis, Alissandra L.; Dibble, Christian C.; Asara, John M.; Szabo, Gyongy; Sicinski, Piotr; Miao, Ji; Lee, Yu-Ru; Pan, Lifeng; Shaw, Reuben J.; Yuan, Junying; Wei, Wenyi
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Harvard University; Harvard Medical School; Salk Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; St Jude Children's Research Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Huazhong University of Science & Technology; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Jinan University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Academia Sinica - Taiwan; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS
摘要：Adenosine monophosphate-activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell death are not fully understood. We report that metabolic stress promoted receptor-interacting protein kinase 1 (RIPK1) activation mediated by TRAIL receptors, whereas AMPK inhibited RIPK1 by phosphorylation at Ser(415) to suppress energy stress-induced cell death. I...
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作者：Dickson, J. L.; Palumbo, A. M.; Head, J. W.; Kerber, L.; Fassett, C. I.; Kreslavsky, M. A.
作者单位：California Institute of Technology; Brown University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; National Aeronautics & Space Administration (NASA); University of California System; University of California Santa Cruz; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory
摘要：Gullies on Mars resemble water-carved channels on Earth, but they are mostly at elevations where liquid water is not expected under current climate conditions. It has been suggested that sublimation of carbon dioxide ice alone could have formed Martian gullies. We used a general circulation model to show that the highest-elevation Martian gullies coincide with the boundary of terrain that experienced pressures above the triple point of water when Mars' rotational axis tilt reached 35 degrees. ...
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作者：Singh, K.; Bradley, C. E.; Anand, S.; Ramesh, V.; White, R.; Bernien, H.
作者单位：University of Chicago; University of Chicago; University of Chicago
摘要：Scaling up invariably error-prone quantum processors is a formidable challenge. Although quantum error correction ultimately promises fault-tolerant operation, the required qubit overhead and error thresholds are daunting. In a complementary proposal, colocated, auxiliary spectator qubits act as in situ probes of noise and enable real-time, coherent corrections of data qubit errors. We used an array of cesium spectator qubits to correct correlated phase errors on an array of rubidium data qubi...
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作者：Iguchi, Yusuke; Shi, Ruby A. A.; Kihou, Kunihiro; Lee, Chul-Ho; Barkman, Mats; Benfenati, Andrea L. L.; Grinenko, Vadim; Babaev, Egor; Moler, Kathryn A. A.
作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; National Institute of Advanced Industrial Science & Technology (AIST); Royal Institute of Technology; Shanghai Jiao Tong University; Stanford University
摘要：Magnetic field penetrates type-II bulk superconductors by forming quantum vortices that enclose a magnetic flux equal to the magnetic flux quantum. The flux quantum is a universal quantity that depends only on fundamental constants. In this study, we investigated isolated vortices in the hole-overdoped Ba1-xKxFe2As2 (x = 0.77) by using scanning superconducting quantum interference device (SQUID) magnetometry. In many locations, we observed objects that carried only part of a flux quantum, with...
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作者：Post, Eric; Kaarlejarvi, Elina; Macias-Fauria, Marc; Watts, David A.; Boving, Pernille Sporon; Cahoon, Sean M. P.; Higgins, R. Conor; John, Christian; Kerby, Jeffrey T.; Pedersen, Christian; Post, Mason; Sullivan, Patrick F.
作者单位：University of California System; University of California Davis; University of Helsinki; University of Oxford; United States Department of Agriculture (USDA); United States Forest Service; Aarhus University; Aarhus University; Norwegian Institute of Bioeconomy Research; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Alaska System; University of Alaska Anchorage; University of California System; University of California Santa Barbara
摘要：Biodiversity is declining globally in response to multiple human stressors, including climate forcing. Nonetheless, local diversity trends are inconsistent in some taxa, obscuring contributions of local processes to global patterns. Arctic tundra diversity, including plants, fungi, and lichens, declined during a 15-year experiment that combined warming with exclusion of large herbivores known to influence tundra vegetation composition. Tundra diversity declined regardless of experimental treat...
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作者：Widen, Sonya A. A.; Bes, Israel Campo; Koreshova, Alevtina; Pliota, Pinelopi; Krogull, Daniel; Burga, Alejandro
作者单位：Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG)
摘要：INTRODUCTION When we think of DNA, we think of inheritance from parent to offspring. However, DNA can also be transmitted between individuals that are not related and even between individuals belonging to different species in a process known as horizontal gene transfer (HGT). Although best characterized in bacteria, a growing body of evidence indicates that HGT can also take place in a wide range of eukaryotes, including fungi, plants, and animals. However, one of the most fascinating aspects ...
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作者：Carman, Peter J.; Barrie, Kyle R.; Rebowski, Grzegorz; Dominguez, Roberto
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：The barbed and pointed ends of the actin filament (F-actin) are the sites of growth and shrinkage and the targets of capping proteins that block subunit exchange, including CapZ at the barbed end and tropomodulin at the pointed end. We describe cryo-electron microscopy structures of the free and capped ends of F-actin. Terminal subunits at the free barbed end adopt a flat F-actin conformation. CapZ binds with minor changes to the barbed end but with major changes to itself. By contrast, subuni...
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作者：Dutton, Jason L.
作者单位：La Trobe University
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作者：Jagerbrand, Annika K.; Spoelstra, Kamiel
作者单位：University of Gavle; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW)
摘要：Anthropogenic light is ubiquitous in areas where humans are present and is showing a progressive increase worldwide. This has far-reaching consequences for most species and their ecosystems. The effects of anthropogenic light on natural ecosystems are highly variable and complex. Many species suffer from adverse effects and often respond in a highly specific manner. Ostensibly surveyable effects such as attraction and deterrence become complicated because these can depend on the type of behavi...
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作者：Epstein, Ziv; Hertzmann, Aaron
作者单位：Massachusetts Institute of Technology (MIT); Adobe Systems Inc.; University of Washington; University of Washington Seattle
