Science

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• RHINO directs MMEJ to repair DNA breaks in mitosis AI翻译
  作者：Brambati, Alessandra; Sacco, Olivia; Porcella, Sarina; Heyza, Joshua; Kareh, Mike; Schmidt, Jens C.; Sfeir, Agnel
  作者单位：Memorial Sloan Kettering Cancer Center; Michigan State University; Michigan State University
  摘要：Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas microhomology-mediated end-joining (MMEJ) has been regarded as a backup mechanism. Through CRISPR-Cas9-based synthetic lethal screens in cancer cells, we identified subunits of the 9-1-1 complex (RAD9A-RAD1-HUS1) and its interacting partner, RHINO, as crucial MMEJ factors. We uncovered an unexpected function for RHINO in restrictin...
• Superconductivity claim electrifies social media AI翻译
  作者：Cho, Adrian
• Researchers raise alarm over threat to Mexican fireflies AI翻译
  作者：Servick, Kelly
• A mammalian DNA methylation landscape AI翻译
  作者：de Mendoza, Alex
  作者单位：University of London; Queen Mary University London
• Wandering seeds AI翻译
  作者：Pennisi, Elizabeth
• Observatory to probe origins of ferocious gamma rays AI翻译
  作者：Clery, Daniel
• Climate shifts orchestrated hominin interbreeding events across Eurasia AI翻译
  作者：Ruan, Jiaoyang; Timmermann, Axel; Raia, Pasquale; Yun, Kyung-Sook; Zeller, Elke; Mondanaro, Alessandro; Di Febbraro, Mirko; Lemmon, Danielle; Castiglione, Silvia; Melchionna, Marina
  作者单位：Institute for Basic Science - Korea (IBS); Pusan National University; Pusan National University; University of Florence; University of Molise
  摘要：When, where, and how often hominin interbreeding happened is largely unknown. We study the potential for Neanderthal-Denisovan admixture using species distribution models that integrate extensive fossil, archaeological, and genetic data with transient coupled general circulation model simulations of global climate and biomes. Our Pleistocene hindcast of past hominins' habitat suitability reveals pronounced climate-driven zonal shifts in the main overlap region of Denisovans and Neanderthals in...
• BIOMEDICINE Key study of cancer microbiomes challenged AI翻译
  作者：Offord, Catherine
  摘要：Description Major errors may undermine research that identified cancers based on their microbes Major errors may undermine research that identified cancers based on their microbes
• Global water use efficiency saturation due to increased vapor pressure deficit AI翻译
  作者：Li, Fei; Xiao, Jingfeng; Chen, Jiquan; Ballantyne, Ashley; Jin, Ke; Li, Bing; Abraha, Michael; John, Ranjeet
  作者单位：Chinese Academy of Agricultural Sciences; Institute of Grassland Research, CAAS; Michigan State University; University System Of New Hampshire; University of New Hampshire; University of Montana System; University of Montana; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; University of South Dakota; University of South Dakota
  摘要：The ratio of carbon assimilation to water evapotranspiration (ET) of an ecosystem, referred to as ecosystem water use efficiency (WUEeco), is widely expected to increase because of the rising atmospheric carbon dioxide concentration (C-a). However, little is known about the interactive effects of rising C-a and climate change on WUEeco. On the basis of upscaled estimates from machine learning methods and global FLUXNET observations, we show that global WUEeco has not risen since 2001 because o...
• Hydroformylation of pyrolysis oils to aldehydes and alcohols from polyolefin waste AI翻译
  作者：Li, Houqian; Wu, Jiayang; Jiang, Zhen; Ma, Jiaze; Zavala, Victor M.; Landis, Clark R.; Mavrikakis, Manos; Huber, George W.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; United States Department of Energy (DOE); Argonne National Laboratory; University of Wisconsin System; University of Wisconsin Madison
  摘要：Waste plastics are an abundant feedstock for the production of renewable chemicals. Pyrolysis of waste plastics produces pyrolysis oils with high concentrations of olefins (>50 weight %). The traditional petrochemical industry uses several energy-intensive steps to produce olefins from fossil feedstocks such as naphtha, natural gas, and crude oil. In this work, we demonstrate that pyrolysis oil can be used to produce aldehydes through hydroformylation, taking advantage of the olefin functional...