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作者：Ferraro, Paul J.; Cherry, Todd L.; Shogren, Jason F.; Vossler, Christian A.; Cason, Timothy N.; Flint, Hilary Byerly; Hochard, Jacob P.; Johansson-Stenman, Olof; Martinsson, Peter; Murphy, James J.; Newbold, Stephen C.; Thunstroem, Linda; van Soest, Daan; van 't Veld, Klaas; Dannenberg, Astrid; Loewenstein, George F.; van Boven, Leaf
作者单位：Johns Hopkins University; Johns Hopkins University; University of Wyoming; University of Tennessee System; University of Tennessee Knoxville; Purdue University System; Purdue University; University of Wyoming; University of Gothenburg; Technical University of Denmark; University of Alaska System; University of Alaska Anchorage; Tilburg University; Universitat Kassel; Carnegie Mellon University; University of Colorado System; University of Colorado Boulder
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作者：Schulze, Christopher J.; Seamon, Kyle J.; Zhao, Yulei; Yang, Yu C.; Cregg, Jim; Kim, Dongsung; Tomlinson, Aidan; Choy, Tiffany J.; Wang, Zhican; Sang, Ben; Pourfarjam, Yasin; Lucas, Jessica; Cuevas-Navarro, Antonio; Ayala-Santos, Carlos; Vides, Alberto; Li, Chuanchuan; Marquez, Abby; Zhong, Mengqi; Vemulapalli, Vidyasiri; Weller, Caroline; Gould, Andrea; Whalen, Daniel M.; Salvador, Anthony; Milin, Anthony; Saldajeno-Concar, Mae; Dinglasan, Nuntana; Chen, Anqi; Evans, Jim; Knox, John E.; Koltun, Elena S.; Singh, Mallika; Nichols, Robert; Wildes, David; Gill, Adrian L.; Smith, Jacqueline A. M.; Lito, Piro
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
摘要：The discovery of small-molecule inhibitors requires suitable binding pockets on protein surfaces. Proteins that lack this feature are considered undruggable and require innovative strategies for therapeutic targeting. KRAS is the most frequently activated oncogene in cancer, and the active state of mutant KRAS is such a recalcitrant target. We designed a natural product-inspired small molecule that remodels the surface of cyclophilin A (CYPA) to create a neomorphic interface with high affinity...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Leslie, Mitch
摘要：Agency launches major effort to explore importance of accumulating mutations in somatic cells
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作者：Price, Michael
摘要：Wildfires, intensified by climate change and perhaps human activity, may have doomed Southern California's big mammals 13,000 years ago
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作者：Elliott, Christian
作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
摘要：Lucky low tide helped Anchorage dodge catastrophic 1964 tsunami, first analysis of location's risk finds
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作者：Liu, Lee R.; Rosenberg, Dina; Changala, P. Bryan; Crowley, Philip J. D.; Nesbitt, David J.; Yao, Norman Y.; Tscherbul, Timur V.; Ye, Jun
作者单位：National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Harvard University; University of Colorado System; University of Colorado Boulder; Nevada System of Higher Education (NSHE); University of Nevada Reno
摘要：Ergodicity, the central tenet of statistical mechanics, requires an isolated system to explore all available phase space constrained by energy and symmetry. Mechanisms for violating ergodicity are of interest for probing nonequilibrium matter and protecting quantum coherence in complex systems. Polyatomic molecules have long served as a platform for probing ergodicity breaking in vibrational energy transport. Here, we report the observation of rotational ergodicity breaking in an unprecedented...
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作者：Wai, Jonathan
作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
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作者：Brainard, Jeffrey
