作者：Vollmer, Steven V.; Selwyn, Jason D.; Despard, Brecia A.; Roesel, Charles L.
作者单位：Northeastern University
摘要：White band disease (WBD) has caused unprecedented declines in the Caribbean Acropora corals, which are now listed as critically endangered species. Highly disease-resistant Acropora cervicornis genotypes exist, but the genetic underpinnings of disease resistance are not understood. Using transmission experiments, a newly assembled genome, and whole-genome resequencing of 76 A. cervicornis genotypes from Florida and Panama, we identified 10 genomic regions and 73 single-nucleotide polymorphisms...
作者：Wang, Yijie; Li, Qihao; Tao, Bo; Angelini, Marina; Ramadoss, Sivakumar; Sun, Baiming; Wang, Ping; Krokhaleva, Yuliya; Ma, Feiyang; Gu, Yiqian; Espinoza, Alejandro; Yamauchi, Ken; Pellegrini, Matteo; Novitch, Bennett; Olcese, Riccardo; Qu, Zhilin; Song, Zhen; Deb, Arjun
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Peng Cheng Laboratory; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Northwestern University; Feinberg School of Medicine; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：After heart injury, dead heart muscle is replaced by scar tissue. Fibroblasts can electrically couple with myocytes, and changes in fibroblast membrane potential can lead to myocyte excitability, which suggests that fibroblast-myocyte coupling in scar tissue may be responsible for arrhythmogenesis. However, the physiologic relevance of electrical coupling of myocytes and fibroblasts and its impact on cardiac excitability in vivo have never been demonstrated. We genetically engineered a mouse t...
作者：Cox, Alexander A.; Keller, C. Brenhin
作者单位：Dartmouth College
摘要：The end-Cretaceous mass extinction was marked by both the Chicxulub impact and the ongoing emplacement of the Deccan Traps flood basalt province. To understand the mechanism of extinction, we must disentangle the timing, duration, and intensity of volcanic and meteoritic environmental forcings. In this study, we used a parallel Markov chain Monte Carlo approach to invert for carbon dioxide (CO2) and sulfur dioxide (SO2) emissions, export productivity, and remineralization from 67 to 65 million...
