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• Two-stage evolution of mammalian adipose tissue thermogenesis AI翻译
  作者：Keipert, Susanne; Gaudry, Michael J.; Kutschke, Maria; Keuper, Michaela; Dela Rosa, Margeoux A. S.; Cheng, Yiming; Monroy Kuhn, Jose M.; Laterveer, Rutger; Cotrim, Camila A.; Giere, Peter; Perocchi, Fabiana; Feederle, Regina; Crichton, Paul G.; Lutter, Dominik; Jastroch, Martin
  作者单位：Stockholm University; University of East Anglia; Technical University of Munich; University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; German Center for Diabetes Research (DZD); Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leibniz Institut fur Evolutions und Biodiversitatsforschung; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health
  摘要：Brown adipose tissue (BAT) is a heater organ that expresses thermogenic uncoupling protein 1 (UCP1) to maintain high body temperatures during cold stress. BAT thermogenesis is considered an overarching mammalian trait, but its evolutionary origin is unknown. We show that adipose tissue of marsupials, which diverged from eutherian mammals similar to 150 million years ago, expresses a nonthermogenic UCP1 variant governed by a partial transcriptomic BAT signature similar to that found in eutheria...
• Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer AI翻译
  作者：Klomp, Jennifer E.; Diehl, J. Nathaniel; Klomp, Jeffrey A.; Edwards, A. Cole; Yang, Runying; Morales, Alexis J.; Taylor, Khalilah E.; Drizyte-Miller, Kristina; Bryant, Kirsten L.; Schaefer, Antje; Johnson, Jared L.; Huntsman, Emily M.; Yaron, Tomer M.; Pierobon, Mariaelena; Baldelli, Elisa; Prevatte, Alex W.; Barker, Natalie K.; Herring, Laura E.; Petricoin III, Emanuel F.; Graves, Lee M.; Cantley, Lewis C.; Cox, Adrienne D.; Der, Channing J.; Stalnecker, Clint A.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Columbia University; George Mason University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS-driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant pancreatic cancer. We determined that ERK1 and ERK2 share near-identical signaling and transforming outputs and that the KRAS-regulated phosphoproteome is driven nearly completely by ERK. We identified 4666 ERK-dependent phosphosites on 2123 proteins, of which 79 and 66%, respectively, were not previous...
• Satellite will aid studies of clouds and warming AI翻译
  作者：Brainard, Jeffrey
• New tool detects dubious papers via 'tortured acronyms' AI翻译
  作者：O'Grady, Cathleen
  摘要：Generated by plagiarism disguisers, these red flags can point to deeper problems with a paper
• Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers AI翻译
  作者：Klomp, Jeffrey A.; Klomp, Jennifer E.; Stalnecker, Clint A.; Bryant, Kirsten L.; Edwards, A. Cole; Drizyte-Miller, Kristina; Hibshman, Priya S.; Diehl, J. Nathaniel; Lee, Ye S.; Morales, Alexis J.; Taylor, Khalilah E.; Peng, Sen; Tran, Nhan L.; Herring, Laura E.; Prevatte, Alex W.; Barker, Natalie K.; Hover, Laura D.; Hallin, Jill; Chowdhury, Saikat; Coker, Oluwadara; Lee, Hey Min; Goodwin, Craig M.; Gautam, Prson; Olson, Peter; Christensen, James G.; Shen, John P.; Kopetz, Scott; Graves, Lee M.; Lim, Kian-Huat; Wang-Gillam, Andrea; Wennerberg, Krister; Cox, Adrienne D.; Der, Channing J.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Illumina; Mayo Clinic; Mayo Clinic Phoenix; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Mirati Therapeutics, Inc.; University of Texas System; UTMD Anderson Cancer Center; University of Helsinki; Washington University (WUSTL); University of Copenhagen; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal-regulated kinase (ERK)-dependent gene transcription in KRAS-mutant cancer to delineate the molecular mechanisms of growth and of inhibitor resistance. Unexpectedly, our KRAS-dependent gene signature diverges substantially from the frequently cited Hallmark KRAS signaling gene signature, is driven predominantly through the ERK mitogen-activated ...
• Little-known virus is on the rise in South America AI翻译
  作者：Moutinho, Sofia
  摘要：Deforestation and climate change may be helping Oropouche virus spread far beyond the Amazon Basin
• The future of life AI翻译
  作者：Woolfson, Adrian
  摘要：A futurist probes the potential of engineered organisms and biologically inspired devices
• Localized thermal emission from topological interfaces AI翻译
  作者：Ergoktas, M. Said; Kecebas, Ali; Despotelis, Konstantinos; Soleymani, Sina; Bakan, Gokhan; Kocabas, Askin; Principi, Alessandro; Rotter, Stefan; Ozdemir, Sahin K.; Kocabas, Coskun
  作者单位：University of Manchester; University of Manchester; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Koc University; University of Manchester; Technische Universitat Wien; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Manchester; National Physical Laboratory - UK
  摘要：The control of thermal radiation by shaping its spatial and spectral emission characteristics plays a key role in many areas of science and engineering. Conventional approaches to tailoring thermal emission using metamaterials are hampered both by the limited spatial resolution of the required subwavelength material structures and by the materials' strong absorption in the infrared. In this work, we demonstrate an approach based on the concept of topology. By changing a single parameter of a m...
• A tiny, long-distance hunter AI翻译
  作者：Gordillo, Leonardo; Cerda, Enrique
  作者单位：Universidad de Santiago de Chile
  摘要：Lacrymaria olor cytoskeleton and membrane origami enables rapid cell hyperextension
• Missed connections AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
  摘要：A sociologist confronts the future of care work in an age of automation