Science

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• Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I AI翻译
  作者：Grba, Daniel N.; Wright, John J.; Yin, Zhan; Fisher, William; Hirst, Judy
  作者单位：University of Cambridge; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge
  摘要：Respiratory complex I is an efficient driver for oxidative phosphorylation in mammalian mitochondria, but its uncontrolled catalysis under challenging conditions leads to oxidative stress and cellular damage. Ischemic conditions switch complex I from rapid, reversible catalysis into a dormant state that protects upon reoxygenation, but the molecular basis for the switch is unknown. We combined precise biochemical definition of complex I catalysis with high-resolution cryo-electron microscopy s...
• A family's sacrifice AI翻译
  作者：Abudayyeh, Abdullah M.
• Integrated platform for multi-scale molecular imaging and phenotyping of the human brain AI翻译
  作者：Park, Juhyuk; Wang, Ji; Guan, Webster; Gjesteby, Lars A.; Pollack, Dylan; Kamentsky, Lee; Evans, Nicholas B.; Stirman, Jeff; Gu, Xinyi; Zhao, Chuanxi; Marx, Slayton; Kim, Minyoung E.; Choi, Seo Woo; Snyder, Michael; Chavez, David; Su-Arcaro, Clover; Tian, Yuxuan; Park, Chang Sin; Zhang, Qiangge; Yun, Dae Hee; Moukheiber, Mira; Feng, Guoping; Yang, X. William; Keene, C. Dirk; Hof, Patrick R.; Ghosh, Satrajit S.; Frosch, Matthew P.; Brattain, Laura J.; Chung, Kwanghun
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Institute for Basic Science - Korea (IBS); Lincoln Laboratory; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Massachusetts Institute of Technology (MIT); University of Washington; University of Washington Seattle; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Seoul National University (SNU)
  摘要：Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the human organ-scale system. We developed a platform that simultaneously extracts spatial, molecular, morphological, and connectivity information of individual cells from the same human brain. The platform includes three core elements: a vibrating microtome for ...
• Spectrally engineered textile for radiative cooling against urban heat islands AI翻译
  作者：Wu, Ronghui; Sui, Chenxi; Chen, Ting-Hsuan; Zhou, Zirui; Li, Qizhang; Yan, Gangbin; Han, Yu; Liang, Jiawei; Hung, Pei-Jan; Luo, Edward; Talapin, Dmitri V.; Hsu, Po-Chun
  作者单位：University of Chicago; Duke University; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory
  摘要：Radiative cooling textiles hold promise for achieving personal thermal comfort under increasing global temperature. However, urban areas have heat island effects that largely diminish the effectiveness of cooling textiles as wearable fabrics because they absorb emitted radiation from the ground and nearby buildings. We developed a mid-infrared spectrally selective hierarchical fabric (SSHF) with emissivity greatly dominant in the atmospheric transmission window through molecular design, minimi...
• Speciation patterns of zinc in ocean particles AI翻译
  作者：Cutter, Gregory
  作者单位：Old Dominion University
  摘要：Different particulate zinc forms ultimately affect marine biological productivity
• Astronauts face health risks-even on short trips in space AI翻译
  作者：Skibba, Ramin
  摘要：New studies include health data collected from space tourists on first privately funded orbital mission
• Human activities shape global patterns of decomposition rates in rivers AI翻译
  作者：Tiegs, S. D.; Capps, K. A.; Costello, D. M.; Schmidt, J. P.; Patrick, C. J.; Follstad Shah, J. J.; Leroy, C. J.
  作者单位：Oakland University; University System of Georgia; University of Georgia; United States Department of Energy (DOE); Savannah River Ecology Laboratory; University System of Georgia; University of Georgia; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; William & Mary; Virginia Institute of Marine Science; Utah System of Higher Education; University of Utah
  摘要：Rivers and streams contribute to global carbon cycling by decomposing immense quantities of terrestrial plant matter. However, decomposition rates are highly variable and large-scale patterns and drivers of this process remain poorly understood. Using a cellulose-based assay to reflect the primary constituent of plant detritus, we generated a predictive model (81% variance explained) for cellulose decomposition rates across 514 globally distributed streams. A large number of variables were imp...
• Sacrificed Maya boys tied to myth of 'Hero Twins' AI翻译
  作者：Curry, Andrew
  摘要：Ancient DNA shows continuity between living and ancient Maya communities
• Psychedelics field looks ahead after FDA advisers' rejection AI翻译
  作者：Kupferschmidt, Kai
  摘要：Reeling from negative vote on MDMA-assisted PTSD therapy, researchers seek lessons for future studies
• Integrity concerns about NIH research surge AI翻译
  作者：Warren, Matthew