Science

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• An even earlier last common ancestor AI翻译
  作者：Brainard, Jeffrey
• Birds optimize fruit size consumed near their geographic range limits AI翻译
  作者：Martins, Lucas P.; Stouffer, Daniel B.; Blendinger, Pedro G.; Boehning-Gaese, Katrin; Costa, Jose Miguel; Dehling, D. Matthias; Donatti, Camila I.; Emer, Carine; Galetti, Mauro; Heleno, Ruben; Menezes, Icaro; Morante-Filho, Jose Carlos; Munoz, Marcia C.; Neuschulz, Eike Lena; Pizo, Marco Aurelio; Quitian, Marta; Ruggera, Roman A.; Saavedra, Francisco; Santillan, Vinicio; Schleuning, Matthias; da Silva, Luis Pascoal; da Silva, Fernanda Ribeiro; Tobias, Joseph A.; Traveset, Anna; Vollstaedt, Maximilian G. R.; Tylianakis, Jason M.
  作者单位：University of Canterbury; Universidad Nacional de Tucuman; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad Nacional de Tucuman; Universidad Nacional de Tucuman; Miguel Lillo Foundation; Goethe University Frankfurt; Universidade de Coimbra; Monash University; Conservation International; Northern Arizona University; Jardim Botanico do Rio de Janeiro; Universidade Estadual Paulista; State University System of Florida; Florida International University; Universidade Estadual de Santa Cruz; Universidad de La Salle; Consejo Superior de Investigaciones Cientificas (CSIC); ATTITUS Educacao; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad Mayor de San Andres; Universidad Catolica de Cuenca; Universidade do Porto; Universidade do Porto; Imperial College London; University of Copenhagen; University of Canterbury
  摘要：Animals can adjust their diet to maximize energy or nutritional intake. For example, birds often target fruits that match their beak size because those fruits can be consumed more efficiently. We hypothesized that pressure to optimize diet-measured as matching between fruit and beak size-increases under stressful environments, such as those that determine species' range edges. Using fruit-consumption and trait information for 97 frugivorous bird and 831 plant species across six continents, we ...
• Probe to study close-by asteroid AI翻译
  作者：Brainard, Jeffrey
• Dynamics of high-speed electrical tree growth in electron-irradiated polymethyl methacrylate AI翻译
  作者：Sturge, Kathryn M.; Hoppis, Noah; Bussio, Ariana M.; Barney, Jonathan; Beaudoin, Brian; Brown, Cameron; Carlsten, Bruce; Chun, Carolyn; Clifford, Bryson C.; Cumings, John; Dallmann, Nicholas; Fitzgibbon, Jack; Frashure, Emily H.; Hammell, Ashley E.; Hannan, Jose; Henderson, Samuel L.; Hiebert, Miriam E.; Krutzler, James; Lichthardt, Joseph; Marr-Lyon, Mark; Montano, Thomas; Moody, Nathan; Mueller, Alexander; O'Shea, Patrick; Schneider, Ryan; Smith, Karl; Tappan, Bryce; Tiemann, Clayton; Walter, David; Koeth, Timothy W.
  作者单位：University System of Maryland; University of Maryland College Park; United States Department of Energy (DOE); Los Alamos National Laboratory
  摘要：Dielectric materials are foundational to our modern-day communications, defense, and commerce needs. Although dielectric breakdown is a primary cause of failure of these systems, we do not fully understand this process. We analyzed the dielectric breakdown channel propagation dynamics of two distinct types of electrical trees. One type of these electrical trees has not been formally classified. We observed the propagation speed of this electrical tree type to exceed 10 million meters per secon...
• Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells AI翻译
  作者：Lin, Zhi; Schaefer, Kaitlin; Lui, Irene; Yao, Zi; Fossati, Andrea; Swaney, Danielle L.; Palar, Ajikarunia; Sali, Andrej; Wells, James A.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco
  摘要：Proximity labeling proteomics (PLP) strategies are powerful approaches to yield snapshots of protein neighborhoods. Here, we describe a multiscale PLP method with adjustable resolution that uses a commercially available photocatalyst, Eosin Y, which upon visible light illumination activates different photo-probes with a range of labeling radii. We applied this platform to profile neighborhoods of the oncogenic epidermal growth factor receptor and orthogonally validated more than 20 neighbors u...
• Cruise set to restore critical Indian Ocean mooring array AI翻译
  作者：Chandrashekar, Vaishnavi
• High bar for famine declaration delays food aid AI翻译
  作者：Roberts, Leslie
  摘要：Lack of humanitarian action during early stages of acute food insecurity takes a heavy toll
• Obesity in Bangladesh: Study food near schools AI翻译
  作者：Karimuzzaman, Md
  作者单位：Drexel University
• Ice sheet-free West Antarctica during peak early Oligocene glaciation AI翻译
  作者：Klages, J. P.; Hillenbrand, C. D.; Bohaty, S. M.; Salzmann, U.; Bickert, T.; Lohmann, G.; Knahl, H. S.; Gierz, P.; Niu, L.; Titschack, J.; Kuhn, G.; Frederichs, T.; Mueller, J.; Bauersachs, T.; Larter, R. D.; Hochmuth, K.; Ehrmann, W.; Nehrke, G.; Rodriguez-Tovar, F. J.; Schmiedl, G.; Spezzaferri, S.; Laeufer, A.; Lisker, F.; van de Flierdt, T.; Eisenhauer, A.; Uenzelmann-Neben, G.; Esper, O.; Smith, J. A.; Paelike, H.; Spiegel, C.; Dziadek, R.; Ronge, T. A.; Freudenthal, T.; Gohl, K.
  作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Ruprecht Karls University Heidelberg; Northumbria University; University of Bremen; University of Bremen; University of Bremen; RWTH Aachen University; University of Tasmania; Leipzig University; University of Granada; University of Hamburg; University of Fribourg; Imperial College London; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Texas A&M University System; Texas A&M University College Station
  摘要：One of Earth's most fundamental climate shifts, the greenhouse-icehouse transition 34 million years ago, initiated Antarctic ice sheet buildup, influencing global climate until today. However, the extent of the ice sheet during the Early Oligocene Glacial Maximum (similar to 33.7 to 33.2 million years ago) that immediately followed this transition-a critical knowledge gap for assessing feedbacks between permanently glaciated areas and early Cenozoic global climate reorganization-is uncertain. ...
• Binding and sensing diverse small molecules using shape-complementary pseudocycles AI翻译
  作者：An, Linna; Said, Meerit; Tran, Long; Majumder, Sagardip; Goreshnik, Inna; Lee, Gyu Rie; Juergens, David; Dauparas, Justas; Anishchenko, Ivan; Coventry, Brian; Bera, Asim K.; Kang, Alex; Levine, Paul M.; Alvarez, Valentina; Pillai, Arvind; Norn, Christoffer; Feldman, David; Zorine, Dmitri; Hicks, Derrick R.; Li, Xinting; Sanchez, Mariana Garcia; Vafeados, Dionne K.; Salveson, Patrick J.; Vorobieva, Anastassia A.; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Flanders Institute for Biotechnology (VIB); Vrije Universiteit Brussel
  摘要：We describe an approach for designing high-affinity small molecule-binding proteins poised for downstream sensing. We use deep learning-generated pseudocycles with repeating structural units surrounding central binding pockets with widely varying shapes that depend on the geometry and number of the repeat units. We dock small molecules of interest into the most shape complementary of these pseudocycles, design the interaction surfaces for high binding affinity, and experimentally screen to ide...