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作者：Enserink, Martin
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作者：Satterlee, James W.; Alonso, David; Gramazio, Pietro; Jenike, Katharine M.; He, Jia; Arrones, Andrea; Villanueva, Gloria; Plazas, Mariola; Ramakrishnan, Srividya; Benoit, Matthias; Gentile, Iacopo; Hendelman, Anat; Shohat, Hagai; Fitzgerald, Blaine; Robitaille, Gina M.; Green, Yumi; Swartwood, Kerry; Passalacqua, Michael J.; Gagnon, Edeline; Hilgenhof, Rebecca; Huggins, Trevis D.; Eizenga, Georgia C.; Gur, Amit; Rutten, Twan; Stein, Nils; Yao, Shengrui; Poncet, Adrien; Bellot, Clement; Frary, Amy; Knapp, Sandra; Bendahmane, Mohammed; Saerkinen, Tiina; Gillis, Jesse; Van Eck, Joyce; Schatz, Michael C.; Eshed, Yuval; Prohens, Jaime; Vilanova, Santiago; Lippman, Zachary B.
作者单位：Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; Howard Hughes Medical Institute; Universitat Politecnica de Valencia; Johns Hopkins University; Johns Hopkins University; INRAE; Cold Spring Harbor Laboratory; Cornell University; Boyce Thompson Institute for Plant Research; University of Guelph; United States Department of Agriculture (USDA); Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Martin Luther University Halle Wittenberg; New Mexico State University; New Mexico State University; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Mount Holyoke College; Natural History Museum London; University of Toronto; University of Toronto; Cornell University; Weizmann Institute of Science
摘要：An enduring question in evolutionary biology concerns the degree to which episodes of convergent trait evolution depend on the same genetic programs, particularly over long timescales. In this work, we genetically dissected repeated origins and losses of prickles-sharp epidermal projections-that convergently evolved in numerous plant lineages. Mutations in a cytokinin hormone biosynthetic gene caused at least 16 independent losses of prickles in eggplants and wild relatives in the genus Solanu...
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作者：Yuan, Zuanning; Georgescu, Roxana; Yao, Nina Y.; Yurieva, Olga; O'Donnell, Michael E.; Li, Huilin
作者单位：Van Andel Institute; Rockefeller University; Howard Hughes Medical Institute
摘要：The proliferating cell nuclear antigen (PCNA) clamp encircles DNA to hold DNA polymerases (Pols) to DNA for processivity. The Ctf18-RFC PCNA loader, a replication factor C (RFC) variant, is specific to the leading-strand Pol (Pol epsilon). We reveal here the underlying mechanism of Ctf18-RFC specificity to Pol epsilon using cryo-electron microscopy and biochemical studies. We found that both Ctf18-RFC and Pol epsilon contain specific structural features that direct PCNA loading onto DNA. Unlik...
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作者：Qian, Suxin; Takeuchi, Ichiro
作者单位：Xi'an Jiaotong University; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
摘要：Emerging solid-state cooling technologies may help reduce overall carbon emissions
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作者：Rochmyaningsih, Dyna
摘要：European Union faces calls to delay commodity import rules aimed at protecting forests
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作者：Zhu, Yangyang; Meerschaert, Kimberly A.; Galvan-Pena, Silvia; Bin, Na-Ryum; Yang, Daping; Basu, Himanish; Kawamoto, Ryo; Shalaby, Amre; Liberles, Stephen D.; Mathis, Diane; Benoist, Christophe; Chiu, Isaac M.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
摘要：Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays of molecularly defined neuron subsets and of immunocyte lineages remains unclear. We used a chemogenetic approach to activate eight distinct neuronal subsets, assessing effects by deep immunophenotyping, microbiome profiling, and immunocyte transcriptomics in intestinal organs. Distinct immune perturbations followed neuronal activation: Nitrergic neurons reg...
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作者：Enserink, Martin
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作者：Shao, Baihao; Fu, Heyifei; Aprahamian, Ivan
作者单位：Dartmouth College; University of Oxford; University of Oxford
摘要：Pumping ions against a concentration gradient through protein-based transporters is a cornerstone of numerous biological processes. Mimicking this function by using artificial receptors remains a daunting challenge, mainly because of the difficulties in balancing between the requirement for high binding affinities and precise and on-demand ion capture and release properties. We report a trimeric hydrazone photoswitch-based receptor that converts light energy into work by actively transporting ...
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作者：Chen, Yihua; Yang, Ning; Zheng, Guanhaojie; Pei, Fengtao; Zhou, Wentao; Zhang, Yu; Li, Liang; Huang, Zijian; Liu, Guilin; Yin, Ruiyang; Zhou, Huanping; Zhu, Cheng; Song, Tinglu; Hu, Chun; Zheng, Dezhi; Bai, Yang; Duan, Ye; Ye, Yakuan; Wu, Yiliang; Chen, Qi
作者单位：Beijing Institute of Technology; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Zhangjiang Laboratory; Peking University; Jiangnan University; Beijing Institute of Technology
摘要：Wide-bandgap (WBG) absorbers in tandem configurations suffer from poor crystallinity and weak texture, which leads to severe mixed halide-cation ion migration and phase segregation during practical operation. We control WBG film growth insensitive to compositions by nucleating the 3C phase before any formation of bromine-rich aggregates and 2H phases. The resultant WBG absorbers show improved crystallinity and strong texture with suppressed nonradiative recombination and enhanced resistance to...
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作者：Mervis, Jeffrey; Ortega, Rodrigo Perez
摘要：After dispute over coproduction, U.S. National Academies takes unprecedented step of stopping $2 million study
