Nature

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• Dementia is deadly - the UN needs to take it more seriously AI翻译
  作者：Barbarino, Paola
• Simulation of matter-antimatter creation on quantum platforms AI翻译
  作者：Burrello, Michele
  作者单位：University of Pisa
• Psilocybin's lasting action requires pyramidal cell types and 5-HT2A receptors AI翻译
  作者：Shao, Ling-Xiao; Liao, Clara; Davoudian, Pasha A.; Savalia, Neil K.; Jiang, Quan; Wojtasiewicz, Cassandra; Tan, Diran; Nothnagel, Jack D.; Liu, Rong-Jian; Woodburn, Samuel C.; Bilash, Olesia M.; Kim, Hail; Che, Alicia; Kwan, Alex C.
  作者单位：Cornell University; Yale University; Yale University; Yale University; Korea Advanced Institute of Science & Technology (KAIST); Cornell University; Weill Cornell Medicine
  摘要：Psilocybin is a serotonergic psychedelic with therapeutic potential for treating mental illnesses1, 2, 3-4. At the cellular level, psychedelics induce structural neural plasticity5,6, exemplified by the drug-evoked growth and remodelling of dendritic spines in cortical pyramidal cells7, 8-9. A key question is how these cellular modifications map onto cell-type-specific circuits to produce the psychedelics' behavioural actions10. Here we use in vivo optical imaging, chemogenetic perturbation an...
• Yvonne Choquet-Bruhat obituary: mathematician who established that Einstein's equations mirror the real world AI翻译
  作者：Dafermos, Mihalis
  作者单位：University of Cambridge
• Making concrete sustainable globally requires technology transfer AI翻译
  作者：Wen, Chengqian; Xu, Xintao; Guo, Huiping
  作者单位：Qingdao University of Technology
• 'Missing' air pollution is tracked to its ephemeral source AI翻译
  作者：[Anonymous]
• A cryptic role for reciprocal helping in a cooperatively breeding bird AI翻译
  作者：Earl, Alexis D.; Carter, Gerald G.; Berlinger, Arden G.; Korir, Elkana; Shah, Shailee S.; Watetu, Wilson N.; Rubenstein, Dustin R.
  作者单位：Columbia University; Princeton University; Smithsonian Institution; Smithsonian Tropical Research Institute; Howard Hughes Medical Institute; Cornell University; University of Cambridge; Cornell University
  摘要：Identifying the mechanisms that underlie cooperation is fundamental to biology1. The most complex form of cooperation in vertebrates occurs in cooperative breeders, in which helpers forego reproduction and assist in raising the young of others, typically relatives2. Not all cooperative societies, however, are kin-based-nearly half of all avian3 and mammalian4 cooperative breeders form mixed-kin societies, much like those of humans5. Kin selection in mixed-kin societies occurs when individuals ...
• Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation AI翻译
  作者：Hosseini, Amir; Dhall, Abhinav; Ikonen, Nemo; Sikora, Natalia; Nguyen, Sylvain; Shen, Yuqi; Amaral, Maria Luisa Jurgensen; Jiao, Alan; Wallner, Felice; Sergeev, Philipp; Lim, Yuhua; Yang, Yuanqin; Vick, Binje; Kawabata, Kimihito Cojin; Melnick, Ari; Vyas, Paresh; Ren, Bing; Jeremias, Irmela; Psaila, Bethan; Heckman, Caroline A.; Blanco, M. Andres; Shi, Yang
  作者单位：Ludwig Institute for Cancer Research; University of Oxford; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Helsinki; University of Oxford; University of California System; University of California San Diego; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Helmholtz Association; German Cancer Research Center (DKFZ); Cornell University; Weill Cornell Medicine; Oxford University Hospitals NHS Foundation Trust; University of Munich; University of Pennsylvania
  摘要：Impaired differentiation is a hallmark of myeloid malignancies1,2. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promyelocytic leukaemia3, but whether 'differentiation therapy' is a generalizable therapeutic approach for acute myeloid leukaemia (AML) and beyond remains incompletely understood. Here we demonstrate that simultaneous inhibition of the histone demethylase LS...
• Web-scraping AI bots cause disruption for scientific databases and journals AI翻译
  作者：Kwon, Diana
• Lipid-degrading small molecule kills cancer cells by ferroptosis AI翻译
  作者：Lange, Mike; Olzmann, James A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley