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作者：Li, Yan; Zhang, Hua; Sun, Cong; Dong, Xiao-Dong; Xie, Chu; Liu, Yuan-Tao; Lin, Ruo-Bin; Kong, Xiang-Wei; Hu, Zhu-Long; Ma, Xiao-Yan; Dai, Dan-Ling; Zhu, Qian-Ying; Li, Yu-Chun; Li, Ying; Liu, Shang-Xin; Yuan, Li; Zhou, Peng-Hui; Gao, Song; Tang, Ya-Ping; Yang, Jin-Ying; Han, Ping; McGuire, Andrew T.; Zhao, Bo; Bei, Jin-Xin; Robertson, Erle; Zeng, Yi-Xin; Zhong, Qian; Zeng, Mu-Sheng
作者单位：State Key Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Guangzhou Medical University; Sun Yat Sen University; Fred Hutchinson Cancer Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Pennsylvania; Sun Yat Sen University
摘要：Epstein-Barr virus (EBV) persistently infects more than 90% of the human population, causing infectious mononucleosis1, susceptibility to autoimmune diseases2 and multiple malignancies of epithelial or B cell-origin3. EBV infects epithelial cells and B cells through interaction between viral glycoproteins and different host receptors4, but it has remained unknown whether a common receptor mediates infection of its two major host cell targets. Here, we establish R9AP as a crucial EBV receptor f...
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作者：Ahart, Jenna
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作者：Rudnitsky, Anna; Oh, Hanna; Margolin, Maya; Dassa, Bareket; Shteinberg, Inbar; Stoler-Barak, Liat; Shulman, Ziv; Kedmi, Ranit
作者单位：Weizmann Institute of Science; Weizmann Institute of Science
摘要：To absorb nutrients and support commensal microorganisms, the host induces tolerogenic immune responses through peripheral regulatory T (pTreg) cells1,2. Previous studies identified conventional type 1 dendritic cells (cDC1s) as initiators of dietary pTreg cells3. However, here we report that food-specific pTreg cells are induced exclusively by the recently identified ROR gamma t antigen-presenting cells4, 5, 6, 7-8 and not by conventional dendritic cells. Instead, our data suggest that pTreg ...
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作者：Ezran, Camille; Liu, Shixuan; Chang, Stephen; Ming, Jingsi; Botvinnik, Olga; Penland, Lolita; Tarashansky, Alexander; de Morree, Antoine; Travaglini, Kyle J.; Zhao, Jia; Wang, Gefei; Hasegawa, Kazuteru; Sin, Hosu; Sit, Rene; Okamoto, Jennifer; Sinha, Rahul; Zhang, Yue; Karanewsky, Caitlin J.; Pendleton, Jozeph L.; Morri, Maurizio; Perret, Martine; Aujard, Fabienne; Stryer, Lubert; Artandi, Steven; Fuller, Margaret T.; Weissman, Irving L.; Rando, Thomas A.; Ferrell Jr, James E.; Wang, Bo; De Vlaminck, Iwijn; Yang, Can; Casey, Kerriann M.; Albertelli, Megan A.; Pisco, Angela Oliveira; Karkanias, Jim; Neff, Norma; Wu, Angela Ruohao; Quake, Stephen R.; Krasnow, Mark A.
作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford University; East China Normal University; East China Normal University; Chan Zuckerberg Initiative (CZI); Stanford University; Stanford University; Aarhus University; Hong Kong University of Science & Technology; Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Stanford University; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Stanford University; Stanford University; Cornell University; Stanford University; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Stanford University
摘要：Mouse lemurs are the smallest and fastest reproducing primates, as well as one of the most abundant, and they are emerging as a model organism for primate biology, behaviour, health and conservation. Although much has been learnt about their ecology and phylogeny in Madagascar and their physiology, little is known about their cellular and molecular biology. Here we used droplet-based and plate-based single-cell RNA sequencing to create Tabula Microcebus, a transcriptomic atlas of 226,000 cells...
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作者：Hoover, Gregory; Gilbert, Shila; Curley, Olivia; Obellianne, Clemence; Lin, Mike T.; Hixson, William; Pierce, Terry W.; Andrews, Joel F.; Alexeyev, Mikhail F.; Ding, Yi; Bu, Ping; Behbod, Fariba; Medina, Daniel; Chang, Jeffrey T.; Ayala, Gustavo; Grelet, Simon
作者单位：University of South Alabama; University of South Alabama; University of South Alabama; University of South Alabama; University of Texas System; University of Texas Health Science Center Houston; University of Kansas; University of Kansas Medical Center; Baylor College of Medicine; University of Texas System; University of Texas Health Science Center Houston
摘要：The nervous system has a pivotal role in cancer biology, and pathological investigations have linked intratumoural nerve density to metastasis1. However, the precise impact of cancer-associated neurons and the communication channels at the nerve-cancer interface remain poorly understood. Previous cancer denervation models in rodents and humans have highlighted robust cancer dependency on nerves, but the underlying mechanisms that drive nerve-mediated cancer aggressivity remain unknown2,3. Here...
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作者：Lee, John H.; Sergeeva, Alina P.; Ahlsen, Goran; Mannepalli, Seetha; Bahna, Fabiana; Goodman, Kerry M.; Xu, Runzhe; Khakh, Baljit S.; Weiner, Joshua A.; Shapiro, Lawrence; Honig, Barry; Zipursky, S. Lawrence
作者单位：University of California System; University of California Los Angeles; Columbia University; Columbia University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Iowa; University of Iowa; Columbia University; Columbia University
摘要：Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance1, 2, 3-4. Clustered protocadherin (cPcdh) proteins, which comprise a large family of isoform-specific homophilic recognition molecules, have a pivotal role in the neuronal self-avoidance that is required for mammalian brain development5, 6-7. The probabilistic expression of different cPcdh isoforms confers unique identities on neurons and forms the basis for neuronal processes to ...
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作者：Qian, Xuyu; Coleman, Kyle; Jiang, Shunzhou; Kriz, Andrea J.; Marciano, Jack H.; Luo, Chunyu; Cai, Chunhui; Manam, Monica Devi; Caglayan, Emre; Lai, Abbe; Exposito-Alonso, David; Otani, Aoi; Ghosh, Urmi; Shao, Diane D.; Andersen, Rebecca E.; Neil, Jennifer E.; Johnson, Robert; LeFevre, Alexandra; Hecht, Jonathan L.; Micali, Nicola; Sestan, Nenad; Rakic, Pasko; Miller, Michael B.; Sun, Liang; Stringer, Carsen; Li, Mingyao; Walsh, Christopher A.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University System of Maryland; University of Maryland Baltimore; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Yale University; Yale University; Yale University; Yale University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：The human cerebral cortex is composed of six layers and dozens of areas that are molecularly and structurally distinct1, 2, 3-4. Although single-cell transcriptomic studies have advanced the molecular characterization of human cortical development, a substantial gap exists owing to the loss of spatial context during cell dissociation5, 6, 7-8. Here we used multiplexed error-robust fluorescence in situ hybridization (MERFISH)9, augmented with deep-learning-based nucleus segmentation, to examine...
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作者：Sharples, Jason
作者单位：University of New South Wales Sydney
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作者：[Anonymous]
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作者：Ahart, Jenna; Witze, Alexandra
